Suramin sodium CAS: 129-46-4
MF: C51H34N6O23S6•6Na
MW: 1429.17

Suramin sodium (CAS 129-46-4)

Suramin sodium | CAS 129-46-4 is rated 5.0 out of 5 by 2.
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Alternate Names: Suramin sodium is also known as Germanin.
Application: Suramin sodium is a non-selective P2 purinergic antagonist, blocking G protein coupling and inhibiting PDGF, EGF, TGFb, SIRT1 and SIRT5.
CAS Number: 129-46-4
Purity: ≥98%
Molecular Weight: 1429.17
Molecular Formula: C51H34N6O23S66Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Suramin Sodium uncouples G proteins from receptors by blocking their interaction with intracellular, P2X and P2Y, purinergic receptor domains. The compound also inhibits the cell surface binding of various growth factors including PDGF, FGF-2 (FGFb), FGF-1 (FGFa), EGF and TGF-β. It is a potent competitive inhibitor of reverse transcriptase and protects T lymphocytes against in vitro human immunodeficiency virus infection. Suramin Sodium has been observed as a potent inhibitor of melanoma HPA (heparanase) and tumor cell metastasis. Inhibition of NAD+-dependent deacetylase SIRT1 with an IC50 of 2.6 μM along with SIRT5 has also been observed. Suramin Sodium has been recorded to antagonize EDG-3 (S1P3) selectively. Suramin Sodium is an inhibitor of A cyclase, FGF-1, FGF-2, IL-1, IL-4, PDGF, PC-PLD, PKC, SH-PTP, TERT, TGF beta 1, Topo I, Topo II and VEGF. Suramin sodium is also known as Suramine sodium salt, Suramin hexasodium salt, Germanin, NF 060, BAY 205, and 8,8′-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt.


References

1. De Clercq, E. 1979. Cancer Lett. 8: 9-22. PMID: 92362
2. Mitsuya, H., et al. 1984. Science. 226: 172-174. PMID: 6091268
3. Hosang, M. 1985. J. Cell. Biochem. 29: 265-273. PMID: 4077932
4. Betsholtz, C., et al. 1986. Proc. Natl. Acad. Sci. U.S.A. 83: 6440-6444. PMID: 3018732
5. Coffey, R.J., et al. 1987. J. Cell. Physiol. 132: 143-148. PMID: 3496343
6. Kopp, R. and Pfeiffer, A. 1990. Cancer Res. 50: 6490-6496. PMID: 2170005
7. Huang, R.R., et al. 1990. Mol. Pharmacol. 37: 304-310. PMID: 2154676
8. Nakajima, M., et al. 1991. J. Biol. Chem. 266: 9661-9666. PMID: 2033058
9. Ancellin, N. and Hla, T. 1999. J. Biol. Chem. 274: 18997-19002. PMID: 10383399

Physical State :
Solid
Solubility :
Soluble in water (50 mg/mL), 95% ethanol, and DMSO (10 mM). Insoluble in benzene, ether, and chloroform.
Storage :
Store at room temperature
IC50 :
Trypanosoma brucei: IC50 = 43 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
QM7000000
PubChem CID :
8514
Merck Index :
14: 9006
MDL Number :
MFCD00210217
EC Number :
204-949-3
SMILES :
CC1=C(C=C(C=C1)C(=O)NC2=C3C(=CC(=CC3=C(C=C2)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])NC(=O)C4=CC(=CC=C4)NC(=O)NC5=CC=CC(=C5)C(=O)NC6=C(C=CC(=C6)C(=O)NC7=C8C(=CC(=CC8=C(C=C7)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])C.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]

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Certificate of Analysis

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Suramin sodium (CAS 129-46-4)  Product Citations

See how others have used Suramin sodium (CAS 129-46-4). Click on the entry to view the PubMed entry .

Citations 1 to 9 of 9 total

PMID: # 27226534  Chen, L. et al. 2016. The Journal of biological chemistry.

PMID: # 26112648  Albulescu, IC. et al. 2015. Antiviral research. 121: 39-46.

PMID: # 25989529  Torres-Fuentes, JL. et al. 2015. Journal of cellular physiology. 230: 3068-75.

PMID: # 26187851  Li, S. et al. 2015. Journal of cell science. 128: 3317-29.

PMID: # 25822366  Chen, CW. et al. 2015. Nature medicine. 21: 335-43.

PMID: # 24829459  Calderon, MR. et al. 2014. Nucleic acids research. 42: 7012-27.

PMID: # 32582693  Front Cell Dev Biol. 387.

PMID: # 31413199  Proc. Natl. Acad. Sci. U.S.A. 17361-17370.

PMID: # 32075857  J. Immunol. 204: 1904-1918.

Citations 1 to 9 of 9 total

Are you able to identify the impurities please? Or advise in respect of their toxicity? Thanks :)

Asked by: Lizzie
Thank you for your question. This chemical has not been tested for impurities. Also, this is a non-hazardous chemical.
Answered by: Technical Support
Date published: 2019-09-11

I am about to start a safety and pharmacokinetics studies of a new formulation of suramin in animals can i use your material? if so can i get bulk quantities like 100g?

Asked by: oyoo
Thank you for your question. Our chemicals are intended for research use only, and not intended for diagnostic or therapeutic use. Please contact our Special Orders Department to inquire about the availability of this chemical in larger quantities. Please e-mail <[email protected]>.
Answered by: Technical Support
Date published: 2017-11-03

How can I buy suramin for IV usages

Asked by: Muhubet
Thank you for your question. We do not recommend using this chemical for diagnostic or therapeutic use. Our compounds are not pharmaceutical grade and not manufactured under GMP guidelines. They are intended for research use only.
Answered by: Technical Support
Date published: 2018-08-04

After aliquoting, should this chemical be stored at room temperature or can it be stored in the freezer?

Asked by: Jz28sail
Thank you for your question. This chemical can be stored in the freezer just fine. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2020-05-05
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Rated 5 out of 5 by from Awesome Curative Info Results are phenomenal .......... sharing with all family and friends!
Date published: 2020-05-06
Rated 5 out of 5 by from Ancellin et al Ancellin et al. (PubMed ID 10383399) found that suramin sodium antagonized Sphingosine 1-phosphate (SPP) activation of EDG-3 signal transduction. -SCBT Publication Review
Date published: 2015-02-27
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