Molecular structure of Suramin sodium, CAS Number: 129-46-4
Suramin sodium (CAS 129-46-4)
See product citations (5)
Alternate Names:
BAY 205; Germanin; NF 060
CAS Number:
129-46-4
Molecular Weight:
1429.17
Molecular Formula:
C51H34N6O23S6•6Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Suramin sodium is a symmetrical hexasulfonated naphthylurea that has been utilized as a research tool in various biochemical applications. It acts as a competitive inhibitor of several enzymes, including those involved in purine metabolism, and as such, it has been employed to study the regulation and inhibition of these enzymes in metabolic pathways. Additionally, Suramin sodium is used in the investigation of cellular signaling pathways, as it can non-selectively interfere with the binding of growth factors to their receptors, thereby modulating cell growth and differentiation processes. In studies of protein-protein interactions, Suramin sodium provides insights into the structural requirements for binding specificity and the effects of such interactions on cellular functions. Moreover, due to its polyanionic nature, this compound is used in the exploration of heparin-binding protein domains and the influence of glycosaminoglycans on protein function. Its high negative charge density makes Suramin sodium a useful agent in the study of charge-charge interactions in biological systems.
Suramin sodium (CAS 129-46-4) References
- Structure-activity relationships of suramin and pyridoxal-5'-phosphate derivatives as P2 receptor antagonists. | Lambrecht, G., et al. 2002. Curr Pharm Des. 8: 2371-99. PMID: 12369951
- Tissue protective and anti-fibrotic actions of suramin: new uses of an old drug. | Liu, N. and Zhuang, S. 2011. Curr Clin Pharmacol. 6: 137-42. PMID: 21470104
- Falcipain-2 inhibition by suramin and suramin analogues. | Marques, AF., et al. 2013. Bioorg Med Chem. 21: 3667-73. PMID: 23680445
- Suramin is a novel activator of PP5 and biphasically modulates S100-activated PP5 activity. | Yamaguchi, F., et al. 2014. Appl Biochem Biotechnol. 172: 237-47. PMID: 24068474
- Suramin inhibits cullin-RING E3 ubiquitin ligases. | Wu, K., et al. 2016. Proc Natl Acad Sci U S A. 113: E2011-8. PMID: 27001857
- Suramin Targets the Conserved Ligand-Binding Pocket of Human Raf1 Kinase Inhibitory Protein. | Guo, C., et al. 2021. Molecules. 26: PMID: 33670019
- Use of Platelet-Rich Plasma Plus Suramin, an Antifibrotic Agent, to Improve Muscle Healing After Injuries. | Tsai, WC., et al. 2021. Am J Sports Med. 49: 3102-3112. PMID: 34351815
- Targeted Redesign of Suramin Analogs for Novel Antimicrobial Lead Development. | Dey, D., et al. 2021. J Chem Inf Model. 61: 4442-4454. PMID: 34516120
- Suramin sodium: pronounced effects on methotrexate transport and anti-folate activity in cultured tumor cells. | Rideout, DC., et al. 1995. Int J Cancer. 61: 840-7. PMID: 7790120
- Liposomal entrapment of suramin. | Chang, HC. and Flanagan, DR. 1994. J Pharm Sci. 83: 1043-6. PMID: 7965662
- Modulation of CD4 by suramin. | Allen, PD., et al. 1993. Clin Exp Immunol. 91: 141-6. PMID: 8419075
- Suramin: a novel antineoplastic agent with multiple potential mechanisms of action. | Stein, CA. 1993. Cancer Res. 53: 2239-48. PMID: 8485709
- Suramin is an active site-directed, reversible, and tight-binding inhibitor of protein-tyrosine phosphatases. | Zhang, YL., et al. 1998. J Biol Chem. 273: 12281-7. PMID: 9575179
Inhibitor of:
4933425L06Rik, A cyclase, A530099J19Rik, Adenovirus hexon protein, alpha-L-iduronidase, AMPD2, AMPD3, ANG V, Angptl1, AP4A Hydrolase, apoL9b, Arbp, ART2, Arylsulfatase B, Arylsulfatase E, Arylsulfatase F, Arylsulfatase G, Arylsulfatase J, Ataxin-7, ATPase, ATPGD1, BC049730, BDP1, Bordetella pertussis toxin subunit S1, C13orf16, CANT1, CD203a, CD39, CD39L4, ChM-I, CHST5, CHST6, CLEC-14A, Clusterin-L1, CMPK2, COL29A1, DC-SIGNR, DCL-1, DDX10, DDX12, DDX16, DDX19B, DDX34, DDX35, DDX40, DDX42, DDX47, DDX49, DDX50, DDX57, DDX59, DHX32, DHX33, DNA-PKCS, E330016A19Rik, Ear1, EDG-3, EG619597, EG665927, EG667094, EGF, Enpp4, ENPP5, EXOSC5, EXT2, EXTL1, FGF-1, FGF-2, FGL1, ficolin A, FLJ13611, Gα 14, Gα 15, Gα i-1, Gα i-2, Gα q, Gβ 3, Gβ 4, Gβ 5, Gγ 10, Gγ 11, Gγ 5, Gγ 9, Gγ4, GAIP, GEN1, GLCE, Glycophorin A, Gm14496, Gm436, GNGT2, GPR101, GPR139, GPR144, GPR176, GPR179, GPR61, GRHPR, HAS1, HDGF, HDHD3, HMG-1, HMG-20A, HPA, HPSE2_Hpse2, HS3ST3B1, HS3ST6, HS6ST2, HSV-1 VP22, HYAL4, IL-1, IL-4, ILT-8, Influenza B NA, Isthmin, Isw1p, KRTAP22-2, Krtap4-16, Kua, LALP1, LALP70, Laminin β-4, Luciferase, M13 Major Coat Protein, MBOAT2, Measles H, Measles M, MIPP, MK, Morc2b, MrgA2, MrgA4, MrgA5, MrgA8, MrgA9, MrgB3, MrgB5, MrgB8, Mrgprx3, MTH1, Multimerin-2, Mumps, NCAG1, NCOAT, NDV HN, nm23-M6, NMNAT-3, NMT2, nov, NPT1, NT5DC2, NT5DC3, NTPDase8, NUDC, NUDT16L1, OAS (2′-5′-oligoadenylate synthetase), OASL2, Ob, OCRL1, Olfr1008, Olfr1010, Olfr1014, Olfr1015, Olfr1034, Olfr1048, Olfr1051, Olfr1061, Olfr1086, Olfr1098, Olfr1099, Olfr1111, Olfr1274, Olfr1458, Olfr315, Olfr341, Olfr352, Olfr374, Olfr457, Olfr458, Olfr459, Olfr460, Olfr461, Olfr469, Olfr491, Olfr65, Olfr66, Olfr661, Olfr663, Olfr687, Olfr703, Olfr704, Olfr705, Olfr706, Olfr707, Olfr708, Olfr734, Olfr747, Olfr847, Olfr849, Olfr850, Olfr901, Olfr902, Olfr965, Olfr967, Olfr968, Olfr969, Olfr97, Olr831, opticin, OR10H5, OR10K2, OR1J1, OR1L1, OR1L8, OR1S1, OR1S2, OR3A1, OR4C46, OR4D10, OR5B3, OR5M3, OR9A4, Ovalbumin, P2X2, P2X3, P2X4, P2X6, P2Y11, P2Y4, P2Y5, P2Y7, Pannexin-2, PAPST2, PC-PLD, PC-PLD2C, PDGF, PF4V1, PINLYP, PKC, Pontin 52, PRELP, Proliferin-1, Proliferin-4, PRTFDC1, Psg16, PSG3, PSG4, PSG6, PSG7, PTER, PTN, PTP-H1, PTPλ, PTPρ, PTPN13LY, PTPN20, PTPRCAP, RDH12, RGS1, RGS14, RGS20, RGS21, RGS22, RGS8, RIC-8A, RIC-8B, RNase L, RNH1, Rotavirus, rotavirus C vp6, Rotavirus virus p42, rotavirus vp7, Ruvbl2, Ser/Thr Protein Kinase, SGSM2, SH-PTP, SHP, Sialin, Sir2, SIRT1, SIRT4, SIRT5, SIRT7, SLC17A (solute carrier family 17), SLC26A9, SLC35E1, SMOC-1, SPACA5, Ste4, Streptavidin, Sulf-1, Sulf-2, SUT-1, Syndecan-3, Syndecan-4, Tβ-4, T2R04, T2R21, TAP, TdT, TERT, TEX101, TEX26, TEX29, TGF beta 1, Topo, Topo I, Topo II, TRM12, Twinkle, UDPase, UST, V1RC, V1rc31, V1RI5, VASA, VEGF, Vmn1r103, Vmn1r113, Vmn1r115, Vmn1r119, Vmn1r125, Vmn1r135, Vmn1r142, Vmn1r159, Vmn1r20, Vmn1r90, Vmn2r102, Vmn2r110, Vmn2r123, Vmn2r28, Vmn2r41, Vmn2r43, Vmn2r44, Vmn2r53, Vmn2r63, Vmn2r73, Vmn2r95, Vmn2r96, VWA8, WARP, YY1, ZNHIT2, and ZNHIT6.Activator of:
ACP1, ARHGEF39, C1rb, CD39L1, CD39L2, Dpl, DUSP26, FGF-2, FGF-BP, Gpa1, GPC3, GPR105, GPR17, HS3ST6, LALP70, P2RY8, P2X1, P2X5, Sir4, SIRT6, and stefin A3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Suramin sodium, 50 mg | sc-507209 | 50 mg | $149.00 | |||
Suramin sodium, 100 mg | sc-507209F | 100 mg | $210.00 | |||
Suramin sodium, 250 mg | sc-507209A | 250 mg | $714.00 | |||
Suramin sodium, 1 g | sc-507209B | 1 g | $2550.00 | |||
Suramin sodium, 10 g | sc-507209C | 10 g | $10750.00 | |||
Suramin sodium, 25 g | sc-507209D | 25 g | $21410.00 | |||
Suramin sodium, 50 g | sc-507209E | 50 g | $40290.00 |