Molecular structure of BPIPP, CAS Number: 325746-94-9
BPIPP (CAS 325746-94-9)
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Alternate Names:
5-(3-Bromophenyl)-5,11-dihydro-1,3-dimethyl-1H-indeno[2′,1′:5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione
Application:
BPIPP is an A cyclase inhibitor
CAS Number:
325746-94-9
Purity:
≥99%
Molecular Weight:
450.28
Molecular Formula:
C22H16BrN3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
BPIPP is an non-competitive guanylyl cyclase (GC) and adenylyl cyclase (AC) inhibitor. Downregulates cAMP and cGMP synthesis, and suppresses cGMP accumulation in a variety of cell lines (IC50 = 3.4 - 11.2 muM). Inhibits GC-stimulated Cl- transport in vitro and suppresses toxin-induced intestinal fluid accumulation in vivo.
BPIPP (CAS 325746-94-9) References
- Pyridopyrimidine derivatives as inhibitors of cyclic nucleotide synthesis: Application for treatment of diarrhea. | Kots, AY., et al. 2008. Proc Natl Acad Sci U S A. 105: 8440-5. PMID: 18559851
- Radiolabeled BMIPP for imaging hepatic fatty acid metabolism: evaluation of hepatic distribution and metabolism in mice at various metabolic statuses induced by fasting in comparison with palmitic acid. | Yamasaki, K., et al. 2015. Mol Imaging. 14: PMID: 25744134
- Assessment of myocardial metabolic disorder associated with mediastinal radiotherapy for esophageal cancer -a pilot study. | Umezawa, R., et al. 2015. Radiat Oncol. 10: 96. PMID: 25896887
- Microvascular obstruction on delayed enhancement cardiac magnetic resonance imaging after acute myocardial infarction, compared with myocardial (201)Tl and (123)I-BMIPP dual SPECT findings. | Mori, H., et al. 2015. Eur J Radiol. 84: 1516-1524. PMID: 26022521
- Myocardial energy provision is preserved by increased utilization of glucose and ketone bodies in CD36 knockout mice. | Nakatani, K., et al. 2015. Metabolism. 64: 1165-74. PMID: 26130608
- Increased Right Ventricular Fatty Acid Accumulation in Chronic Thromboembolic Pulmonary Hypertension. | Sakao, S., et al. 2015. Ann Am Thorac Soc. 12: 1465-72. PMID: 26356218
- Diagnosis and Detection of Myocardial Injury in Active Cardiac Sarcoidosis--Significance of Myocardial Fatty Acid Metabolism and Myocardial Perfusion Mismatch. | Momose, M., et al. 2015. Circ J. 79: 2669-76. PMID: 26477356
- Synthesis and preliminary evaluation of an ¹⁸F-labeled oleic acid analog for PET imaging of fatty acid uptake and metabolism. | Cai, Z., et al. 2016. Nucl Med Biol. 43: 108-115. PMID: 26602329
- Right ventricular sugars and fats in chronic thromboembolic pulmonary hypertension. | Sakao, S., et al. 2016. Int J Cardiol. 219: 143-9. PMID: 27323340
- Regional myocardial damage and active inflammation in patients with cardiac sarcoidosis detected by non-invasive multi-modal imaging. | Kataoka, S., et al. 2017. Ann Nucl Med. 31: 135-143. PMID: 27804054
- Mitochondrial Cardiomyopathy with a Unique 99mTc-MIBI/123I-BMIPP Mismatch Pattern. | Tashiro, R., et al. 2017. Intern Med. 56: 321-325. PMID: 28154277
- Novel GUCY2C variant causing familial diarrhea in a Mennonite kindred and a potential therapeutic approach. | Wolfe, RM., et al. 2021. Am J Med Genet A. 185: 2046-2055. PMID: 33949097
- Concentration-dependent alpha1-Adrenoceptor Antagonism and Inhibition of Neurogenic Smooth Muscle Contraction by Mirabegron in the Human Prostate. | Huang, R., et al. 2021. Front Pharmacol. 12: 666047. PMID: 34248624
Inhibitor of:
A cyclase, Adenylyl Cyclase, Enzyme, and Guanylate Cyclases.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BPIPP, 10 mg | sc-203852 | 10 mg | $189.00 | |||
BPIPP, 50 mg | sc-203852A | 50 mg | $797.00 |