Molecular structure of 2-Methylthio-ADP trisodium salt, CAS Number: 475193-31-8
2-Methylthio-ADP trisodium salt (CAS 475193-31-8)
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Alternate Names:
2-(Methylthio)adenosine 5′-diphosphate; 2-(Methylthio)adenosine-5′-(trihydro gen diphosphate) trisodium salt; 2-Methylthio-ADP
Application:
2-Methylthio-ADP trisodium salt is a P2Y1, P2Y12 and P2Y13 agonist
CAS Number:
475193-31-8
Molecular Weight:
539.24
Molecular Formula:
C11H14N5O10P2S•3Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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2-Methylthio-ADP trisodium salt is a potent purinergic agonist for the receptors P2Y1, P2Y12 and P2Y13 and a platelet aggregating agent. In addition, studies show that 2-Methylthio-ADP trisodium salt functions better as a human platelet A cyclase (adenylate cyclase) inhibitor than a platelet aggregator. Furthermore, 2-Methylthio-ADP trisodium salt is more effective at platelet aggregation and cAMP inhibition than ADP. Alternate studies show that preincubation of human vascular smooth muscle cells with thrombin amplifies the agonist effects of 2-Methylthio-ADP trisodium salt. Upon binding to P2Y12 receptors 2-Methylthio-ADP trisodium salt can increase the induction of interleukin 6 expression and cell mitogenesis. Inhibiting this pathway can be done by RNA interference-mediated knockdown and inhibition of the receptor with the selective antagonist R-138727 (sc-220298).
2-Methylthio-ADP trisodium salt (CAS 475193-31-8) References
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- Expression and function of purinergic P2Y12 receptors in rat trigeminal ganglion neurons. | Kawaguchi, A., et al. 2015. Neurosci Res. 98: 17-27. PMID: 25987295
- P2Y1 Receptor Activation of the TRPV4 Ion Channel Enhances Purinergic Signaling in Satellite Glial Cells. | Rajasekhar, P., et al. 2015. J Biol Chem. 290: 29051-62. PMID: 26475857
- Nucleotides protect rat brain astrocytes against hydrogen peroxide toxicity and induce antioxidant defense via P2Y receptors. | Förster, D. and Reiser, G. 2016. Neurochem Int. 94: 57-66. PMID: 26898403
- P2Y13 receptors mediate presynaptic inhibition of acetylcholine release induced by adenine nucleotides at the mouse neuromuscular junction. | Guarracino, JF., et al. 2016. Neuroscience. 326: 31-44. PMID: 27058149
- Inhibition of ZL55 cell proliferation by ADP via PKC-dependent signalling pathway. | Muscella, A., et al. 2018. J Cell Physiol. 233: 2526-2536. PMID: 28777435
- Distinct Signaling Patterns of Allosteric Antagonism at the P2Y1 Receptor. | Gao, ZG. and Jacobson, KA. 2017. Mol Pharmacol. 92: 613-626. PMID: 28864555
- 2-Methylthioadenosine[beta-32P]diphosphate. An agonist and radioligand for the receptor that inhibits the accumulation of cyclic AMP in intact blood platelets. | Macfarlane, DE., et al. 1983. J Clin Invest. 71: 420-8. PMID: 6298277
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Inhibitor of:
A cyclase, and P2Y1.Activator of:
P2Y1, P2Y12, P2Y13, and PARP-6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Methylthio-ADP trisodium salt, 10 mg | sc-203464 | 10 mg | $838.00 |