2-Methylthio-ADP trisodium salt CAS: 475193-31-8
MF: C11H14N5O10P2S•3Na
MW: 539.24
A P2Y1, P2Y12 and P2Y13 agonist.

2-Methylthio-ADP trisodium salt (CAS 475193-31-8)

2-Methylthio-ADP trisodium salt | CAS 475193-31-8 is rated 5.0 out of 5 by 1.
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Alternate Names: 2-(Methylthio)adenosine 5'-diphosphate; 2-(Methylthio)adenosine-5'-(trihydro gen diphosphate) trisodium salt; 2-Methylthio-ADP
Application: 2-Methylthio-ADP trisodium salt is a P2Y1, P2Y12 and P2Y13 agonist
CAS Number: 475193-31-8
Purity: ≥98%
Molecular Weight: 539.24
Molecular Formula: C11H14N5O10P2S•3Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

2-Methylthio-ADP trisodium salt is a potent purinergic agonist for the receptors P2Y1, P2Y12 and P2Y13 and a platelet aggregating agent. In addition, studies show that 2-Methylthio-ADP trisodium salt functions better as a human platelet adenylate cyclase inhibitor than a platelet aggregator. Furthermore, 2-Methylthio-ADP trisodium salt is more effective at platelet aggregation and cAMP inhibition than ADP. Alternate studies show that preincubation of human vascular smooth muscle cells with thrombin amplifies the agonist effects of 2-Methylthio-ADP trisodium salt. Upon binding to P2Y12 receptors 2-Methylthio-ADP trisodium salt can increase the induction of interleukin 6 expression and cell mitogenesis. Inhibiting this pathway can be done by RNA interference-mediated knockdown and inhibition of the receptor with the selective antagonist R-138727 (sc-220298).


References

1. Cusack, N.J., et al. 1982. Br. J. Pharmacol. 77: 329-333. PMID: 7139191
2. Macfarlane, D.E., et al. 1983. J. Clin. Invest. 71: 420-428. PMID: 6298277
3. Sak, K., et al. 2002. Arch. Biochem. Biophys. 397: 131-136. PMID: 11747319
4. Zhang, F.L., et al. 2002. J. Pharmacol. Exp. Ther. 301: 705-713. PMID: 11961076

Formulation :
10 mM in water
Appearance :
Aqueous solution
Physical State :
Liquid
Solubility :
Soluble in water (50 mM).
Storage :
Store at -20° C
Refractive Index :
n20D 1.88 (Predicted)
IC50 :
P2Y12: EC5050 = 0.89 nM; P2Y1: EC5050 = 2.5 nM (human); P2Y purinoceptor 1: EC5050 = 2.5 nM (meleagris gallopavo); P2Y13: EC5050 = 19 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
MDL Number :
MFCD00153838
SMILES :
[Na+].[Na+].[Na+].CSc1nc(N)c2ncn([[email protected]]3O[[email protected]@H](COP(=O)([O-])OP(=O)([O-])[O-])[[email protected]](O)[[email protected]@H]3O)c2n1

Download SDS (MSDS)

Certificate of Analysis

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2-Methylthio-ADP trisodium salt (CAS 475193-31-8)  Product Citations

See how others have used 2-Methylthio-ADP trisodium salt (CAS 475193-31-8). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 30460241  Tullemans, BME. et al. 2018. Front Cardiovasc Med. 5: 142.

PMID: # 31652008  Transfusion.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Amisten Amisten, S. et al. (PubMed 20526761) used 2-Methylthio-ADP to demonstrate that ADP mediates inhibition of insulin secretion by activation of P2Y13 receptors in mice. -SCBT Publication Review
Date published: 2015-06-11
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