Molecular structure of PD 81,723, CAS Number: 132861-87-1
PD 81,723 (CAS 132861-87-1)
Alternate Names:
(2-Amino-4,5-dimethyl-3-thienyl)-[3-(trifluoromethyl)phenyl]methanone
Application:
PD 81,723 is an allosteric potentiator that increases the functional effects of adenosine and adenosine analogs
CAS Number:
132861-87-1
Purity:
≥99%
Molecular Weight:
299.31
Molecular Formula:
C14H12F3NOS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
PD 81723 is an allosteric potentiator at Adenosine A1-R that acts via agonist-dependent and independent mechanisms. PD 81723 enhances the functional effects of adenosine and adenosine analogs. This compound also inhibits basal and forskolin-stimulated A cyclase (adenylyl cyclase, AC) activity in Adensosine A1-R expressed in CHO cells, possibly via direct potentiation of constitutive receptor activity or by direct inhibition of A cyclase (adenylyl cyclase, AC).
PD 81,723 (CAS 132861-87-1) References
- Differential effects of the adenosine A(1) receptor allosteric enhancer PD 81,723 on agonist binding to brain and adipocyte membranes. | Jarvis, MF., et al. 1999. Brain Res. 840: 75-83. PMID: 10517954
- Effects of the adenosine A1 receptor allosteric modulators PD 81,723 and LUF 5484 on the striatal acetylcholine release. | Bueters, TJ., et al. 2002. Eur J Pharmacol. 454: 177-82. PMID: 12421644
- Hippocampal injury and neurobehavioral deficits are improved by PD 81,723 following hyperglycemic cerebral ischemia. | Meno, JR., et al. 2003. Exp Neurol. 183: 188-96. PMID: 12957503
- Functional activity of the adenosine binding enhancer, PD 81,723, in the in vitro hippocampal slice. | Janusz, CA., et al. 1991. Brain Res. 567: 181-7. PMID: 1817724
- Allosteric enhancement of adenosine A1 receptor binding and function by 2-amino-3-benzoylthiophenes. | Bruns, RF. and Fergus, JH. 1990. Mol Pharmacol. 38: 939-49. PMID: 2174510
- A1 adenosine receptor allosteric enhancer PD-81723 protects against renal ischemia-reperfusion injury. | Park, SW., et al. 2012. Am J Physiol Renal Physiol. 303: F721-32. PMID: 22759398
- The allosteric enhancer, PD 81,723, stabilizes human A1 adenosine receptor coupling to G proteins. | Bhattacharya, S. and Linden, J. 1995. Biochim Biophys Acta. 1265: 15-21. PMID: 7857979
- Characterization of glutamate, aspartate, and GABA release from ischemic rat cerebral cortex. | Phillis, JW., et al. 1994. Brain Res Bull. 34: 457-66. PMID: 7915962
- Allosteric enhancer PD 81,723 acts by novel mechanism to potentiate cardiac actions of adenosine. | Kollias-Baker, C., et al. 1994. Circ Res. 75: 961-71. PMID: 7955150
- Cardiac functional responses to adenosine by PD 81,723, an allosteric enhancer of the adenosine A1 receptor. | Mudumbi, RV., et al. 1993. Am J Physiol. 264: H1017-22. PMID: 8456969
- PD 81,723, an allosteric enhancer of the A1 adenosine receptor, lowers the threshold for ischemic preconditioning in dogs. | Mizumura, T., et al. 1996. Circ Res. 79: 415-23. PMID: 8781475
- Agonist-independent effect of an allosteric enhancer of the A1 adenosine receptor in CHO cells stably expressing the recombinant human A1 receptor. | Kollias-Baker, CA., et al. 1997. J Pharmacol Exp Ther. 281: 761-8. PMID: 9152383
- Adenosine A1 receptor-dependent and -independent effects of the allosteric enhancer PD 81,723. | Musser, B., et al. 1999. J Pharmacol Exp Ther. 288: 446-54. PMID: 9918544
Inhibitor of:
A cyclase.Activator of:
Adenosine A1-R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PD 81,723, 10 mg | sc-204837 | 10 mg | $155.00 | |||
PD 81,723, 50 mg | sc-204837A | 50 mg | $638.00 |