4732456N10Rik Inhibitors

Chemicals classified as indirect Krt90 inhibitors, or more broadly as keratin inhibitors, encompass diverse compounds that can influence the structure and function of keratins by altering cellular processes. These compounds are not directly targeting keratins but can have significant effects on keratin biology through modulation of cell signaling, gene expression, protein synthesis, and assembly of the cytoskeleton. Retinoids like Retinoic Acid, Alitretinoin, and Acitretin are known to regulate gene expression and keratinocyte differentiation, which in turn can lead to changes in keratin expression patterns. Compounds that affect protein synthesis and processing, such as Swainsonine, can alter keratin post-translational modifications, affecting their stability and function. Disruptors of the cytoskeletal network, like Colchicine and Cytochalasin D, can influence keratin filament organization by altering the dynamics of microtubules and actin filaments, which are essential for maintaining the structural integrity of the intermediate filament network.

Withaferin A and Griseofulvin exhibit their influence by interacting with components of the cytoskeleton, potentially leading to disrupted keratin assembly. Substances like Diallyl sulfide and Phenylhydrazine can induce cellular stress responses or oxidative stress, which can result in the modification or degradation of keratin proteins. Solvents such as DMSO are known to penetrate cell membranes and may disrupt protein-protein interactions, potentially affecting keratin filaments. Lastly, exposure to heavy metals like Cadmium chloride can induce cellular stress, contributing to alterations in keratin expression and assembly. These chemicals, while not directly inhibiting keratins, can significantly impact keratin function through a variety of indirect mechanisms.