Molecular structure of Acitretin, CAS Number: 55079-83-9
Acitretin (CAS 55079-83-9)
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Alternate Names:
Neotigason; Soriatane
Application:
Acitretin is a synthetic retinoid - the major metabolite of etretinate
CAS Number:
55079-83-9
Purity:
≥99%
Molecular Weight:
326.43
Molecular Formula:
C21H26O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Acitretin is a synthetic retinoid, the major metabolite of etretinate (sc-205689). It has demonstrated an ability to suppress the development of chemically-induced epithelial tumors, as well as squamous cell carcinoma. Acitretin is an artificial compound derived from vitamin A and shares structural similarities with other retinoids, such as isotretinoin and tretinoin. Its mode of action involves binding to retinoic acid receptors (RARs) and retinoid X receptors (RXRs).
Acitretin (CAS 55079-83-9) References
- Comparison of the in vitro and in vivo effects of retinoids either alone or in combination with cisplatin and 5-fluorouracil on tumor development and metastasis of melanoma. | Liu, X., et al. 2008. Cancer Chemother Pharmacol. 63: 167-74. PMID: 18465132
- In silico functional profiling of small molecules and its applications. | Sato, T., et al. 2008. J Med Chem. 51: 7705-16. PMID: 19032081
- Effectiveness and persistence of acitretin, ciclosporin, fumaric acid esters and methotrexate for patients with moderate-to-severe psoriasis: a cohort study from BADBIR. | Alabas, OA., et al. 2023. Br J Dermatol. 188: 618-627. PMID: 36763783
- Novel use of acitretin for posttransplant Grover's disease and cutaneous graft versus host disease. | Gupta, N., et al. 2023. JAAD Case Rep. 33: 67-69. PMID: 36890866
- Risk of psychiatric disorders in patients with psoriasis prescribed acitretin versus disease-modifying antirheumatic drugs: a nationwide matched cohort study. | Lin, TL., et al. 2023. Dermatology.. PMID: 36948168
- The real-world effectiveness and persistence of acitretin, ciclosporin, fumaric acid esters and methotrexate for treating moderate-to-severe psoriasis. | . 2023. Br J Dermatol. 188: e35. PMID: 37078764
- A case of pityriasis rubra pilaris treated with tofacitinib after failure with acitretin and ixekizumab. | Ying, Y., et al. 2023. Australas J Dermatol.. PMID: 37200390
- When Surgery Won't Cut It: Successful Management of Eruptive Squamous Atypia With Combination Medical Therapy. | Yumeen, S., et al. 2023. Cureus. 15: e37694. PMID: 37206513
- Pembrolizumab-Induced Lichen Planus: A Rare Immune-Related Adverse Side Effect. | Bansal, A., et al. 2023. Indian Dermatol Online J. 14: 391-394. PMID: 37266094
- Basic Therapeutic Approach for Patients with Plaque Psoriasis: Korean Expert Consensus Using the Modified Delphi Method. | Jo, SJ., et al. 2023. Ann Dermatol. 35: 173-182. PMID: 37290951
- Therapeutic potential of stem cells and acitretin on inflammatory signaling pathway-associated genes regulated by miRNAs 146a and 155 in AD-like rats. | Elzayat, EM., et al. 2023. Sci Rep. 13: 9613. PMID: 37311848
- Modulating retinoid-X-receptor alpha (RXRA) expression sensitizes chronic myeloid leukemia cells to imatinib in vitro and reduces disease burden in vivo. | Rajamani, BM., et al. 2023. Front Pharmacol. 14: 1187066. PMID: 37324449
- Systemic monotherapy with acitretin for erythrodermic psoriasis: results of a retrospective study of 81 patients. | Yu, C., et al. 2023. Ther Adv Chronic Dis. 14: 20406223231178412. PMID: 37360416
Inhibitor of:
4732456N10Rik, CRBP I, CRBP II, CRBP III, cystatin A, Cytokeratin 6B, Cytokeratin 6C, DHRS3, DHRS4L2, Ichthyin, KRTAP2-3, KRTAP20-1, KRTAP21-3, KRTAP27-1, KRTAP5-1, Lce1h, LOC283585, LRAT, periplakin, RAI2, RARα1, RBP2, RDH12, RETSAT, RGR, RPE, SPINK9, and TIG2.Activator of:
Basic Cytokeratin, CRABP-I, CRABP-II, CRBP III, CRBP IV, CYP26B1, CYP26C1, DHRS7C, DHRS9, dsg1α, envoplakin, FACL6, Keratin 28, Keratin 40, NP60, RARα1, RARα2, Rarres1, RDH8, Retinal RX, Retinal RX2, SCCA2, Stra6, and TIG3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Acitretin, 25 mg | sc-210754 | 25 mg | $148.00 |