Swainsonine, an indolizidine alkaloid, has been shown to inhibit the breakdown of glycoprotein by rat liver lysosomes and also suppress MAN2A1 (Golgi mannosidase II). This compound has been reported to be a potent antiproliferative and immunomodulatory agent via stimulation of lymphocyte proliferation. Additionally, Swainsonine displays the ability to inhibit MAN2B1 (lysosomal α-mannosidase) and MAN2C1. Mechanistic studies suggest that this agent can alter carbohydrate processing of β-galactosidase and β-glucuronidase.
1. Winkler, J.R., et al. 1984. J. Biol. Chem. 259: 15369-15372. PMID: 6210288 2. Granato, D.A., et al. 1987. Mol. Immunol. 24: 849-855. PMID: 3116410 3. White, S.L., et al. 1988. Biochem. Biophys. Res. Commun. 150: 615-625. PMID: 3124836 4. Humphries, M.J., et al. 1988. Cancer Res. 48: 1410-1415. PMID: 3125963 5. Tropea, J.E., et al. 1988. J. Biol. Chem. 263: 4309-4317. PMID: 3126186
Soluble in 100% ethanol, DMSO, methanol, water (10 mg/ml), DMF (~10 mg/ml), and PBS (pH=7.2) (0.25 mg/ml).
Store at -20° C
102.62° C (Predicted)
~353.3° C at 760 mmHg (Predicted)
~1.4 g/cm3 (Predicted)
lysosomal α-mannosidase and Golgi α-mannosidase II : IC50 = 0.2 µM; golgi alpha-mannosidase 2: IC50 = 0.04 µM (drosophila ); jack bean alpha-mannosidase: IC50 = 0.04 µM
Hi, we hope to order this drug in larger amount. Is there a quote available for ~30mg? Thanks.
Asked by: Stan_DFCI
Thank you for your question. Please contact our Technical Service Department to inquire about special pricing and bulk orders for this chemical. This is for research use only, and not for diagnostic or therapeutic use. Please call us toll-free at (800) 457-3801 option 2, or e-mail <[email protected]>.
Rated 5 out of
ChakrabortyChakraborty, et. al. (PubMed ID 18655794) found that Swainsonine reduced the tyrosinase activity in melanotic hybrid 95-H1 cells by 30 40% when treated with 1 g/ml for 2 days. Increases in migration rate of the tyrosinase protein in SDS-PAGE was also observed post treatment. -SCBT Publication Review
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