Date published: 2026-7-24

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SIRT Antibodies

Santa Cruz Biotechnology features a diverse variety of SIRT monoclonal antibodies for studying sirtuins, a family of proteins involved in cellular regulation, including metabolism, aging, and stress responses. SIRT monoclonal antibodies are compatible with multiple research techniques, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Sirtuins deacetylate proteins that contribute to cellular processes such as DNA repair, gene expression, and apoptosis, maintaining cellular homeostasis and longevity. The involvement of sirtuins in metabolic regulation and their connection to age-related diseases makes them significant targets in both basic and applied research. Understanding sirtuin function can provide insights into therapeutic strategies for conditions such as obesity, diabetes, and neurodegenerative diseases. Research into sirtuin activity continues to reveal new pathways and mechanisms that influence cellular health and aging processes. Investigating sirtuin regulation helps scientists better understand their role in disease prevention and treatment development. SIRT monoclonal antibodies from Santa Cruz Biotechnology enable researchers worldwide to advance scientific understanding of cellular regulation and age-related diseases.

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SIRT Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

SIRT1 Antibody (B-7)

sc-74465mouse IgG1 κ448-747 (h)WB, IP, IF, IHC(P), ELISAm, r, h
175
(35)

SIRT1 Antibody (B-10)

sc-74504mouse IgG2b κ448-747 (h)WB, IP, IF, IHC(P), ELISAh
99
(43)

SIRT1 Antibody (33.36)

sc-135792mouse IgG1 κ(h)WB, IP, IF, IHC(P), ELISAm, r, h
9
(2)

SIRT2 Antibody (A-5)

sc-28298mouse IgG1 κ1-95 (h)WB, IP, IF, IHC(P), ELISAm, r, h
31
(21)

SIRT3 Antibody (F-10)

sc-365175mouse IgG2b κ251-290 (h)WB, IP, IF, ELISAm, r, h
69
(30)

SIRT4 Antibody (95.1)

sc-135797mouse IgG2a κ241-255 (h)WB, IP, ELISAh
12
(2)

SIRT5 Antibody (G-2)

sc-271635mouse IgG1 κFL (h)WB, IP, IF, IHC(P), ELISAm, r, h
9
(12)

SIRT6 Antibody (2G1H1)

sc-517196mouse IgG1 κ141-250 (h)WB, IP, IF, ELISAh
16
(7)

SIRT6 Antibody (6C9-D10-D3)

sc-517556mouse IgG(h)WB, IF, IHC(P)m, r, h
4
(0)

SIRT7 Antibody (C-3)

sc-365344mouse IgG1 κ1-105 (h)WB, IP, IF, ELISAm, r, h
32
(5)

SIRT siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

SIRT1 siRNA (h)

sc-40986hGene SilencingN/A
124
(1)

SIRT1 shRNA Plasmid (h)

sc-40986-SHhGene SilencingPuromycin
124
(1)

SIRT1 shRNA (h) Lentiviral Particles

sc-40986-VhGene SilencingPuromycin
124
(1)

SIRT1 siRNA (m)

sc-40987mGene SilencingN/A
55
(0)

SIRT1 shRNA Plasmid (m)

sc-40987-SHmGene SilencingPuromycin
55
(0)

SIRT1 shRNA (m) Lentiviral Particles

sc-40987-VmGene SilencingPuromycin
55
(0)

SIRT1 siRNA (r)

sc-108043rGene SilencingN/A
45
(0)

SIRT1 shRNA Plasmid (r)

sc-108043-SHrGene SilencingPuromycin
45
(0)

SIRT1 shRNA (r) Lentiviral Particles

sc-108043-VrGene SilencingPuromycin
45
(0)

SIRT2 siRNA (h)

sc-40988hGene SilencingN/A
11
(0)

SIRT2 shRNA Plasmid (h)

sc-40988-SHhGene SilencingPuromycin
11
(0)

SIRT2 shRNA (h) Lentiviral Particles

sc-40988-VhGene SilencingPuromycin
11
(0)

SIRT2 siRNA (m)

sc-40989mGene SilencingN/A
1
(0)

SIRT2 shRNA Plasmid (m)

sc-40989-SHmGene SilencingPuromycin
1
(0)

SIRT2 shRNA (m) Lentiviral Particles

sc-40989-VmGene SilencingPuromycin
1
(0)

SIRT3 siRNA (h)

sc-61555hGene SilencingN/A
44
(1)

SIRT3 shRNA Plasmid (h)

sc-61555-SHhGene SilencingPuromycin
44
(1)

SIRT3 shRNA (h) Lentiviral Particles

sc-61555-VhGene SilencingPuromycin
44
(1)

SIRT3 siRNA (m)

sc-61556mGene SilencingN/A
35
(0)

SIRT3 shRNA Plasmid (m)

sc-61556-SHmGene SilencingPuromycin
35
(0)

SIRT3 shRNA (m) Lentiviral Particles

sc-61556-VmGene SilencingPuromycin
35
(0)

SIRT3-GFP shRNA (h) Lentiviral Particles

sc-61555-VGhGene SilencingPuromycin
44
(1)

SIRT4 siRNA (h)

sc-63024hGene SilencingN/A
5
(0)

SIRT4 shRNA Plasmid (h)

sc-63024-SHhGene SilencingPuromycin
5
(0)

SIRT4 shRNA (h) Lentiviral Particles

sc-63024-VhGene SilencingPuromycin
5
(0)

SIRT4 siRNA (m)

sc-63025mGene SilencingN/A
1
(0)

SIRT4 shRNA Plasmid (m)

sc-63025-SHmGene SilencingPuromycin
1
(0)

SIRT4 shRNA (m) Lentiviral Particles

sc-63025-VmGene SilencingPuromycin
1
(0)

SIRT5 siRNA (h)

sc-63026hGene SilencingN/A
2
(0)

SIRT5 shRNA Plasmid (h)

sc-63026-SHhGene SilencingPuromycin
2
(0)

SIRT5 shRNA (h) Lentiviral Particles

sc-63026-VhGene SilencingPuromycin
2
(0)

SIRT5 siRNA (m)

sc-63027mGene SilencingN/A
2
(0)

SIRT5 shRNA Plasmid (m)

sc-63027-SHmGene SilencingPuromycin
2
(0)

SIRT5 shRNA (m) Lentiviral Particles

sc-63027-VmGene SilencingPuromycin
2
(0)

SIRT6 siRNA (h)

sc-63028hGene SilencingN/A
13
(0)

SIRT6 shRNA Plasmid (h)

sc-63028-SHhGene SilencingPuromycin
13
(0)

SIRT6 shRNA (h) Lentiviral Particles

sc-63028-VhGene SilencingPuromycin
13
(0)

SIRT6 siRNA (m)

sc-63029mGene SilencingN/A
4
(0)

SIRT6 shRNA Plasmid (m)

sc-63029-SHmGene SilencingPuromycin
4
(0)

SIRT6 shRNA (m) Lentiviral Particles

sc-63029-VmGene SilencingPuromycin
4
(0)

SIRT7 siRNA (h)

sc-63030hGene SilencingN/A
11
(0)

SIRT7 shRNA Plasmid (h)

sc-63030-SHhGene SilencingPuromycin
11
(0)

SIRT7 shRNA (h) Lentiviral Particles

sc-63030-VhGene SilencingPuromycin
11
(0)

SIRT7 siRNA (m)

sc-63031mGene SilencingN/A
4
(0)

SIRT7 shRNA Plasmid (m)

sc-63031-SHmGene SilencingPuromycin
4
(0)

SIRT7 shRNA (m) Lentiviral Particles

sc-63031-VmGene SilencingPuromycin
4
(0)

SIRT Transfected Lysates

Empty Table HeaderProduct NameCATALOG #SpeciesCONTROL ANTIBODYCitationsRATING

SIRT1 (h): 293T Lysate

sc-113797h0
(0)

SIRT CRISPR Knockout (KO) and HDR Plasmids

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

SIRT1 CRISPR/Cas9 KO Plasmid (h)

sc-400085Gene Knockouth0
(2)

SIRT1 HDR Plasmid (h)

sc-400085-HDRHomology Directed Repairh0
(2)

SIRT1 CRISPR/Cas9 KO Plasmid (m2)

sc-430046-KO-2Gene Knockoutm0
(0)

SIRT1 HDR Plasmid (m2)

sc-430046-HDR-2Homology Directed Repairm0
(0)

SIRT2 CRISPR/Cas9 KO Plasmid (h2)

sc-400590-KO-2Gene Knockouth0
(1)

SIRT2 HDR Plasmid (h2)

sc-400590-HDR-2Homology Directed Repairh0
(1)

SIRT2 CRISPR/Cas9 KO Plasmid (m)

sc-425703Gene Knockoutm0
(0)

SIRT3 HDR Plasmid (h2)

sc-400675-HDR-2Homology Directed Repairh0
(0)

SIRT3 CRISPR/Cas9 KO Plasmid (m2)

sc-425704-KO-2Gene Knockoutm0
(0)

SIRT3 HDR Plasmid (m2)

sc-425704-HDR-2Homology Directed Repairm0
(0)

SIRT3 CRISPR/Cas9 KO Plasmid (r)

sc-437315Gene Knockoutr0
(0)

SIRT3 HDR Plasmid (r)

sc-437315-HDRHomology Directed Repairr0
(0)

SIRT4 CRISPR/Cas9 KO Plasmid (h)

sc-401187Gene Knockouth0
(0)

SIRT4 HDR Plasmid (h)

sc-401187-HDRHomology Directed Repairh0
(0)

SIRT4 CRISPR/Cas9 KO Plasmid (r)

sc-437316Gene Knockoutr0
(0)

SIRT5 CRISPR/Cas9 KO Plasmid (h)

sc-416994Gene Knockouth0
(0)

SIRT5 HDR Plasmid (h)

sc-416994-HDRHomology Directed Repairh0
(0)

SIRT5 CRISPR/Cas9 KO Plasmid (m)

sc-427028Gene Knockoutm0
(0)

SIRT5 HDR Plasmid (m)

sc-427028-HDRHomology Directed Repairm0
(0)

SIRT5 CRISPR/Cas9 KO Plasmid (r)

sc-437317Gene Knockoutr0
(0)

SIRT5 HDR Plasmid (r)

sc-437317-HDRHomology Directed Repairr0
(0)

SIRT6 CRISPR/Cas9 KO Plasmid (h)

sc-412216Gene Knockouth0
(1)

SIRT6 HDR Plasmid (h)

sc-412216-HDRHomology Directed Repairh0
(1)

SIRT6 CRISPR/Cas9 KO Plasmid (m2)

sc-424467-KO-2Gene Knockoutm0
(0)

SIRT6 HDR Plasmid (m2)

sc-424467-HDR-2Homology Directed Repairm0
(0)

SIRT7 CRISPR/Cas9 KO Plasmid (h)

sc-401401Gene Knockouth0
(0)

SIRT7 HDR Plasmid (h)

sc-401401-HDRHomology Directed Repairh0
(0)

SIRT7 CRISPR/Cas9 KO Plasmid (m)

sc-431608Gene Knockoutm0
(0)

SIRT7 HDR Plasmid (m)

sc-431608-HDRHomology Directed Repairm0
(0)

SIRT CRISPR Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

SIRT1 Double Nickase Plasmid (h)

sc-400085-NICGene Knockouth0
(0)

SIRT1 Double Nickase Plasmid (h2)

sc-400085-NIC-2Gene Knockouth0
(0)

SIRT1 Double Nickase Plasmid (m)

sc-430046-NICGene Knockoutm0
(0)

SIRT1 Double Nickase Plasmid (m2)

sc-430046-NIC-2Gene Knockoutm0
(0)

SIRT2 Double Nickase Plasmid (h)

sc-400590-NICGene Knockouth0
(0)

SIRT2 Double Nickase Plasmid (h2)

sc-400590-NIC-2Gene Knockouth0
(0)

SIRT2 Double Nickase Plasmid (m)

sc-425703-NICGene Knockoutm0
(0)

SIRT3 Double Nickase Plasmid (h)

sc-400675-NICGene Knockouth0
(0)

SIRT3 Double Nickase Plasmid (h2)

sc-400675-NIC-2Gene Knockouth0
(0)

SIRT3 Double Nickase Plasmid (m)

sc-425704-NICGene Knockoutm0
(0)

SIRT3 Double Nickase Plasmid (m2)

sc-425704-NIC-2Gene Knockoutm0
(0)

SIRT3 Double Nickase Plasmid (r)

sc-437315-NICGene Knockoutr0
(0)

SIRT3 Double Nickase Plasmid (r2)

sc-437315-NIC-2Gene Knockoutr0
(0)

SIRT4 Double Nickase Plasmid (h)

sc-401187-NICGene Knockouth0
(0)

SIRT4 Double Nickase Plasmid (h2)

sc-401187-NIC-2Gene Knockouth0
(0)

SIRT4 Double Nickase Plasmid (r)

sc-437316-NICGene Knockoutr0
(0)

SIRT4 Double Nickase Plasmid (r2)

sc-437316-NIC-2Gene Knockoutr0
(0)

SIRT5 Double Nickase Plasmid (h)

sc-416994-NICGene Knockouth0
(0)

SIRT5 Double Nickase Plasmid (h2)

sc-416994-NIC-2Gene Knockouth0
(0)

SIRT5 Double Nickase Plasmid (m)

sc-427028-NICGene Knockoutm0
(0)

SIRT5 Double Nickase Plasmid (m2)

sc-427028-NIC-2Gene Knockoutm0
(0)

SIRT5 Double Nickase Plasmid (r)

sc-437317-NICGene Knockoutr0
(0)

SIRT5 Double Nickase Plasmid (r2)

sc-437317-NIC-2Gene Knockoutr0
(0)

SIRT6 Double Nickase Plasmid (h)

sc-412216-NICGene Knockouth0
(0)

SIRT6 Double Nickase Plasmid (h2)

sc-412216-NIC-2Gene Knockouth0
(0)

SIRT6 Double Nickase Plasmid (m)

sc-424467-NICGene Knockoutm0
(0)

SIRT6 Double Nickase Plasmid (m2)

sc-424467-NIC-2Gene Knockoutm0
(0)

SIRT7 Double Nickase Plasmid (m)

sc-431608-NICGene Knockoutm0
(0)

SIRT CRISPR Activation Plasmids and Lentiviral Particles

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

SIRT1 CRISPR Activation Plasmid (h)

sc-400085-ACTGene Activationh0
(0)

SIRT1 CRISPR Activation Plasmid (h2)

sc-400085-ACT-2Gene Activationh0
(0)

SIRT1 Lentiviral Activation Particles (h)

sc-400085-LACGene Activationh0
(0)

SIRT1 CRISPR Activation Plasmid (m)

sc-430046-ACTGene Activationm0
(0)

SIRT1 CRISPR Activation Plasmid (m2)

sc-430046-ACT-2Gene Activationm0
(0)

SIRT1 Lentiviral Activation Particles (m)

sc-430046-LACGene Activationm0
(0)

SIRT3 CRISPR Activation Plasmid (h)

sc-400675-ACTGene Activationh0
(0)

SIRT3 CRISPR Activation Plasmid (h2)

sc-400675-ACT-2Gene Activationh0
(0)

SIRT3 CRISPR Activation Plasmid (m)

sc-425704-ACTGene Activationm0
(0)

SIRT3 Lentiviral Activation Particles (m)

sc-425704-LACGene Activationm0
(0)

SIRT4 CRISPR Activation Plasmid (h)

sc-401187-ACTGene Activationh0
(0)

SIRT5 CRISPR Activation Plasmid (h)

sc-416994-ACTGene Activationh0
(0)

SIRT5 CRISPR Activation Plasmid (h2)

sc-416994-ACT-2Gene Activationh0
(0)

SIRT6 CRISPR Activation Plasmid (m)

sc-424467-ACTGene Activationm0
(0)

SIRT6 CRISPR Activation Plasmid (m2)

sc-424467-ACT-2Gene Activationm0
(0)

SIRT7 CRISPR Activation Plasmid (h)

sc-401401-ACTGene Activationh0
(0)

SIRT7 CRISPR Activation Plasmid (h2)

sc-401401-ACT-2Gene Activationh0
(0)