Molecular structure of Tubastatin A (trifluoroacetate salt), CAS Number: 1239262-52-2
Tubastatin A (trifluoroacetate salt) (CAS 1239262-52-2)
See product citations (2)
Alternate Names:
N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide 2,2,2-Trifluoroacetate
Application:
Tubastatin A (trifluoroacetate salt) is a neuroprotective HDAC6 and HDAC8 inhibitor
CAS Number:
1239262-52-2
Molecular Weight:
449.40
Molecular Formula:
C22H22F3N3O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM. Comparatively, it demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50s >16 μM), excluding HDAC8 (IC50 = 0.9 μM).
Tubastatin A (trifluoroacetate salt) (CAS 1239262-52-2) References
- Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A. | Butler, KV., et al. 2010. J Am Chem Soc. 132: 10842-6. PMID: 20614936
- Alleviating GAA Repeat Induced Transcriptional Silencing of the Friedreich's Ataxia Gene During Somatic Cell Reprogramming. | Polak, U., et al. 2016. Stem Cells Dev. 25: 1788-1800. PMID: 27615158
- Screening of an Epigenetic Drug Library Identifies 4-((hydroxyamino)carbonyl)-N-(2-hydroxyethyl)-N-Phenyl-Benzeneacetamide that Reduces Melanin Synthesis by Inhibiting Tyrosinase Activity Independently of Epigenetic Mechanisms. | Song, H., et al. 2020. Int J Mol Sci. 21: PMID: 32605171
- High-Throughput Screening for Epigenetic Compounds That Induce Human β-Defensin 1 Synthesis. | Lyu, W., et al. 2023. Antibiotics (Basel). 12: PMID: 36830097
Inhibitor of:
HDAC6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tubastatin A (trifluoroacetate salt), 1 mg | sc-364640 | 1 mg | $79.00 | |||
Tubastatin A (trifluoroacetate salt), 5 mg | sc-364640A | 5 mg | $235.00 | |||
Tubastatin A (trifluoroacetate salt), 10 mg | sc-364640B | 10 mg | $333.00 |