Molecular structure of ERK Inhibitor II, FR180204, CAS Number: 865362-74-9
ERK Inhibitor II, FR180204 (CAS 865362-74-9)
See product citations (45)
Application:
ERK Inhibitor II, FR180204 is a novel ERK-selective inhibitor
CAS Number:
865362-74-9
Purity:
98%
Molecular Weight:
327.34
Molecular Formula:
C18H13N7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
ERK Inhibitor II, FR180204 is a novel ERK-selective inhibitor that can permeate the cell. ERK Inhibitor II, FR180204 has been reported to inhibit ERK1 (Ki=0.31muM), ERK2 (Ki=0.14 muM), TGFbeta-induced AP-1 activation, and acts as a competitive inhibitor of ATP. Additionally, it may act to suppress antigen-specific activation of T cells. Collagen-induced arthritis studies have described that in the presence of ERK Inhibitor II, FR180204 delayed-type hypersensitivity is weakened and there is a decrease in plasma anti-CII antibody levels. Inhibitor-ERK2 complex studies report that ERK Inhibitor II, FR180204 shows little activity towards IKKalpha, MEK1, MKK4, PDGFRalpha, PKCalpha, Src, and Syk. ERK Inhibitor II, FR180204 is an inhibitor of p38 alpha.
ERK Inhibitor II, FR180204 (CAS 865362-74-9) References
- Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex. | Ohori, M., et al. 2005. Biochem Biophys Res Commun. 336: 357-63. PMID: 16139248
- FR180204, a novel and selective inhibitor of extracellular signal-regulated kinase, ameliorates collagen-induced arthritis in mice. | Ohori, M., et al. 2007. Naunyn Schmiedebergs Arch Pharmacol. 374: 311-6. PMID: 17123065
- ERK inhibitors as a potential new therapy for rheumatoid arthritis. | Ohori, M. 2008. Drug News Perspect. 21: 245-50. PMID: 18596988
- Multi-gram scale synthesis of FR180204. | Patnaik, S., et al. 2009. J Org Chem. 74: 8870-3. PMID: 19852504
- Role of ERK1/2 signaling in dengue virus-induced liver injury. | Sreekanth, GP., et al. 2014. Virus Res. 188: 15-26. PMID: 24704674
- Effect of API-1 and FR180204 on cell proliferation and apoptosis in human DLD-1 and LoVo colorectal cancer cells. | Saglam, AS., et al. 2016. Oncol Lett. 12: 2463-2474. PMID: 27698814
- ERK activation is required for the antiepileptogenic effect of low frequency electrical stimulation in kindled rats. | Mardani, P., et al. 2018. Brain Res Bull. 140: 132-139. PMID: 29705048
- Protein Kinase Inhibitors Arrested the In-Vitro Growth of Theileria equi. | Yadav, J., et al. 2020. Acta Parasitol. 65: 644-651. PMID: 32240490
- LPA2 promotes neuronal differentiation and neurite formation in neocortical development. | Uenaka, M., et al. 2022. Biochem Biophys Res Commun. 598: 89-94. PMID: 35151977
- Spermine alleviates experimental autoimmune encephalomyelitis via regulating T cell activation and differentiation. | Zheng, R., et al. 2022. Int Immunopharmacol. 107: 108702. PMID: 35305382
- Analysis of Spontaneous and Induced Osteogenic Differentiation in 3D-micromasses of Human Multipotent Stem Cells. | Lommen, J., et al. 2022. In Vivo. 36: 1067-1076. PMID: 35478128
- High glucose induces an early and transient cytoprotective autophagy in retinal Müller cells. | Mecchia, A., et al. 2022. Endocrine. 77: 221-230. PMID: 35612691
- Bladder Oxidative Stress and HMGB1 Release Contribute to PAR4-Mediated Bladder Pain in Mice. | Ye, S., et al. 2022. Front Syst Neurosci. 16: 882493. PMID: 35645739
- Fluoxetine Decreases Phagocytic Function via REV-ERBα in Microglia. | Jang, DY., et al. 2023. Neurochem Res. 48: 196-209. PMID: 36048349
Inhibitor of:
c-Fgr, C14orf162, C15orf39, C1orf86, C20orf151, C3orf54, DUSP (Dual specificity protein phosphatase), DUSP22, E230028L10Rik, EG231736, Elk-1, ERK 1, ERK 2, Gm15070, MAPBPIP, MAPK15, MAPKAP-1, MAPKBP-1, Mkk2, MPK-1, Olfr875, Olr480, p38 alpha, PHTF2, PP2Cζ, Rsk-3, Ser/Thr Protein Kinase, Ser/Thr protein phosphatase (PP2C), and T2BP.Activator of:
3pK, C030019I05Rik, C030030A07Rik, C030039L03Rik, C030046E11Rik, DAPL1, eIF3K, GOLGA6L, GTSF1, Krs-2, MAP-1B, MAPKAPK-2, MEK-6, MSK1, and PFAAP5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ERK Inhibitor II, FR180204, 1 mg | sc-203945 | 1 mg | $110.00 | |||
ERK Inhibitor II, FR180204, 5 mg | sc-203945A | 5 mg | $165.00 | |||
ERK Inhibitor II, FR180204, 10 mg | sc-203945B | 10 mg | $239.00 | |||
ERK Inhibitor II, FR180204, 50 mg | sc-203945C | 50 mg | $942.00 |