Molecular structure of HA-100 dihydrochloride, CAS Number: 210297-47-5
HA-100 dihydrochloride (CAS 210297-47-5)
See product citations (39)
Alternate Names:
HA-100 dihydrochloride also known as 1-(5-Isoquinolinylsulfonyl)piperazine . 2HCl
Application:
HA-100 dihydrochloride is a isoquinoline compound that can act as an inhibitor of protein kinases including PKA, PKG and PKC
CAS Number:
210297-47-5
Purity:
≥98%
Molecular Weight:
350.26
Molecular Formula:
C13H15N3O2S•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
HA-100 dihydrochloride is an isoquinoline compound with an added piperazinylsulfonyl group that acts as an inhibitor of protein kinases (PKs), including PKA, PKC, and PKG (IC50 = 8, 12, and 4 µM, respectively). It less effectively blocks the activity of myosin light chain kinase (IC50 = 240 µM). It has also been shown to inhibit the activity of various enzymes, such as cyclooxygenase-2 and lipoxygenase. In addition, it inhibits the expression of various genes, including those involved in inflammation and cell proliferation.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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HA-100 dihydrochloride (CAS 210297-47-5) References
- The barley powdery mildew protein kinase C gene, pkc1 and pkc-like gene, are differentially expressed during morphogenesis. | Zhang, Z., et al. 2001. Mol Plant Pathol. 2: 327-37. PMID: 20573022
- Decoupling global biases and local interactions between cell biological variables. | Zaritsky, A., et al. 2017. Elife. 6: PMID: 28287393
- Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives. | Hagiwara, M., et al. 1987. Mol Pharmacol. 32: 7-12. PMID: 2955213
- Role of protein kinases in stimulation of human polymorphonuclear leukocyte oxidative metabolism by various agonists. Differential effects of a novel protein kinase inhibitor. | Gerard, C., et al. 1986. J Clin Invest. 77: 61-5. PMID: 3003155
- Sodium+/taurocholate cotransporting polypeptide as target therapy for liver fibrosis. | Salhab, A., et al. 2022. Gut. 71: 1373-1385. PMID: 34266968
- LPA receptor 1 (LPAR1) is a novel interaction partner of Filamin A that promotes Filamin A phosphorylation, MRTF-A transcriptional activity and oncogene-induced senescence. | Konopa, A., et al. 2022. Oncogenesis. 11: 69. PMID: 36577757
Inhibitor of:
MYLK, PKA, PKC, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HA-100 dihydrochloride, 5 mg | sc-203072 | 5 mg | $163.00 | |||
HA-100 dihydrochloride, 25 mg | sc-203072A | 25 mg | $418.00 |