HA-100 dihydrochloride is an isoquinoline compound with an added piperazinylsulfonyl group that acts as an inhibitor of protein kinases (PKs), including PKA, PKC, and PKG (IC50 = 8, 12, and 4 µM, respectively). HA-100 dihydrochloride less effectively blocks the activity of myosin light chain kinase (IC50 = 240 µM). HA-100 dihydrochloride is also an inhibitor of myosin light chain kinase.
1. Hagiwara, M., et al., 1987. Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives. Molecular pharmacology. 32(1): 7-12. PMID: 2955213
2. Gerard, C., et al., 1986. Role of protein kinases in stimulation of human polymorphonuclear leukocyte oxidative metabolism by various agonists. Differential effects of a novel protein kinase inhibitor. The Journal of clinical investigation. 77(1): 61-5. PMID: 3003155
See how others have used HA-100 dihydrochloride (CAS 84468-24-6). Click on the entry to view the PubMed entry .
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