Molecular structure of Lysophosphatidic Acid, CAS Number: 325465-93-8
Lysophosphatidic Acid (CAS 325465-93-8)
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Alternate Names:
Lysophosphatidic Acid also known as 1-oleoyl-sn-glycero-3-phosphate sodium salt; Oleoyl-L-α-lysophosphatidic acid sodium salt; LPA sodium salt; 3-SN-LYSOPHOSPHATIDIC ACID; 1-OLEOYL-SN-GLYCERO-3-LYSOPHOSPHATIDIC ACID SODIUM SALT; 1-OLEOYL LYSOPHOSPHATIDIC ACID SODIUM SALT
Application:
Lysophosphatidic Acid is a endogenous glycerophospholipid signaling ligand molecule and ligand activator for EDG-2, EDG-4, and EDG-7
CAS Number:
325465-93-8
Purity:
≥98%
Molecular Weight:
458.50
Molecular Formula:
C21H40O7P•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Lysophosphatidic acid (LPA) is an endogenous glycerophospholipid signaling molecule and ligand activator for EDG-2 and EDG-4 (LPA) receptors. Signaling associated with Lysophosphatidic acid has been reported to stimulate growth of fibroblasts, vascular smooth muscle cells, endothelial cells, and keratinocytes. Lysophosphatidic Acid has been indicated as both a proliferative and anti-apoptotic factor, signaling for Pl3K-mediated regulation of cell activity. Lysophosphatidic Acid has also been described to potentiate acetylchloine receptor currents by G-protein-mediated activation of Ca2+-dependent/independent protein kinase C. Lysophosphatidic Acid can bind to one of four G-protein linked receptors to mediate a variety of biological responses including smooth muscle contraction, cell proliferation, neurite retraction and platelet aggregation.
Lysophosphatidic Acid (CAS 325465-93-8) References
- Lysophosphatidic acid synthesis and release. | Pagès, C., et al. 2001. Prostaglandins Other Lipid Mediat. 64: 1-10. PMID: 11324699
- The emerging role of lysophosphatidic acid in cancer. | Mills, GB. and Moolenaar, WH. 2003. Nat Rev Cancer. 3: 582-91. PMID: 12894246
- Mechanisms of lysophosphatidic acid production. | Aoki, J. 2004. Semin Cell Dev Biol. 15: 477-89. PMID: 15271293
- GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5. | Lee, CW., et al. 2006. J Biol Chem. 281: 23589-97. PMID: 16774927
- Two pathways for lysophosphatidic acid production. | Aoki, J., et al. 2008. Biochim Biophys Acta. 1781: 513-8. PMID: 18621144
- Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6. | Yanagida, K., et al. 2009. J Biol Chem. 284: 17731-41. PMID: 19386608
- Aiming drug discovery at lysophosphatidic acid targets. | Tigyi, G. 2010. Br J Pharmacol. 161: 241-70. PMID: 20735414
- Lysophosphatidic Acid signaling in the nervous system. | Yung, YC., et al. 2015. Neuron. 85: 669-82. PMID: 25695267
- Lysophosphatidic acid signalling in development. | Sheng, X., et al. 2015. Development. 142: 1390-5. PMID: 25852197
- Lysophosphatidic acid, a multifunctional phospholipid messenger. | Moolenaar, WH. 1995. J Biol Chem. 270: 12949-52. PMID: 7768880
- Lysophosphatidic acid: a novel growth and survival factor for renal proximal tubular cells. | Levine, JS., et al. 1997. Am J Physiol. 273: F575-85. PMID: 9362335
- Lysophosphatidic acid potentiates ACh receptor currents by G-protein-mediated activation of protein kinase C. | Nishizaki, T. and Sumikawa, K. 1997. Brain Res Mol Brain Res. 50: 121-6. PMID: 9406926
- Lysophosphatidic acid as a potential biomarker for ovarian and other gynecologic cancers. | Xu, Y., et al. 1998. JAMA. 280: 719-23. PMID: 9728644
Inhibitor of:
ABR, DGK-ι, GOLT1A, GPR family (GPCR;G protein-coupled), MOB2, Rab 8A, SAV1, SUSD3, and WWC3.Activator of:
α-protein kinase 1, αPAK, β1-Adaptin, βENaC, 1110032A03Rik, 1700001O22Rik, 1810030N24Rik, 2400001E08Rik, 3BP1, 4921501E09Rik, 4930432K09Rik, 4930549C01Rik, A430078G23Rik, ABHD2, ACBD5, Adducin γ, AFAP-1L2, Angptl1, ANKRD23, Annexin A10, ANXA2R, ANXA8L2, AP1S2, apoAL, ARAP1, Arg, ARHGAP25, ARHGEF18, ARHGEF19, ARHGEF33, ARHGEF37, ARHGEF39, ARHGEF5_Arhgef5, ARHGEF5L, Asp1, Astrotactin, Astrotactin 2, Aytl1b, AZI1, Baz, BIG2, BIN2, BLCAP, BLU, BRDG1, BSMAP, BST-1, c-Fgr, c-Src, C12orf48, C14orf166B, C17orf39_4933439F18Rik, C9orf30, CAGE, Cas-L, CCDC155, CCDC74B, CD1D, CD23, CD30L, CD36, CD88, CD97, Cdc42EP3, Cdc50B, CDCP1, CdGAP, Cdk6, Ceramide Kinase, CGNL1, CHMP4A, CIN85, Cks2, claudin-1, claudin-7, CLDN (Claudin), CLLD6, Clostridium difficile Toxin A, COBLL1, COL13A1, COL15A1, COL1A2, COL27A1, COL3A1, COL4A4, COL4A6, COL6A6, Collagen α2 Type VI, Cortisol, COX1, CXCL13, cyclin D3, CYTL1, D-type cyclin, D830046C22Rik, Dab1, DDR2, desmoglein 3, DIP2C, DIRAS2, Dkk-1, DNAH11, DnaJC12, DnaJC16, DNAJC25-GNG10, DOCK 10, DOCK 11, DOCK 5, Dok-5, Dokl, dolichol kinase, DOLPP1, ECM2, Ect2, EDG-2, EDG-4, EG436336, EG667512, EMILIN-2, EMR2, Ep-CAM, epsin2, ErbB-3, ERK 1, ETAA16, FAM13b, FAM57A, FBF1, Fbxo12, FGD2, FGD5, Fibulin-4, Filamin 3, FIT1, FRMD6, G β1, Gα 11, Gα 12, Gα 13, Gα i-1, Gα i-2, Gβ 3, Gγ 10, Gγ 11, G0S2, GAIP, GAL3ST2, galectin-3, gankyrin, GAPT, GCET2, GDE4, GDPD3, GDPD4, GEFT, GFRαL, GLTPD2, Gm216, GNB1L, GOLGA8R, GPR135, GPR137B, GPR141, GPR144, GPR34, GPR37L1, GPR56, GPR75, GPR87, GPR88, GPR92, GPRC5C, GRHL3, HAPLN3, HAPLN4, HemT-1, HIP3, IFT140, INDOL1, Influenza A m1, Integrin α10, Integrin β7, Integrin X, ITFG1, JAK2, JIP-1, JTB, KIAA1279, KIAA2013_2510039O18Rik, Kindlin-3, KIR5.1, KLK12, KLKBL4, KRTAP12-1, KRTAP12-2, L-Plastin, Lamellipodin, Laminin α-4, Laminin α-5, LANCL3, LAPTM4B, Lingo-1, LPAAT-β, LPAAT-γ, LPAAT-ζ, LPP, LPPR4, Ly-6K, Ly-GDI, LYPLA2, MAGP-1, MAGP-2, MAS1L, MEK-5, MEK2, MEK3, MFAP3, MFAP4, MKX, MMP-11, Mnk2, MOB1A, MOCA, MOSPD2, MPP7, MPP9, MTDH, Mucin 1, Mucin 17, Mucin 4, Myosin Ic, Myotrophin, NCK1, Nek10, Net, NET-4, NHE-3, Nidogen, Nir1, nm23-H1, NOR-1, NPWBP, Nucling, NWD1, OAT2, OCIL, Oculospanin, ORP-6, ORP-8, OSX, P4HA1, PAcP, PAP-2b, PATE2, paxillin, PC-PLD2, PC-PLD3, PCDH15_Pcdh15, PCDHA7, PDGFR-β, Peroxin 1, Peroxin 2, PI 3-kinase p85α, PI 4-kinase α, PI 4-kinase II α, PIG-Y, Pim-1, Pinch-1, PIPPIN, PLA1A, PLA2G4B, PLBD1, PLC β4, PLD, PLEKHG3, PLEKHG4B, plexin-A2, plexin-B1, plexin-B3, PLRG1, PNPLA7, podoplanin, POEM, Popeye 2, POPX2, PRAME like-1, PRELP, PREP-2, PRK1, Procollagen Type I, PSS1, PYK2, R-Ras, Rab 3B, Rab 44, Rab40B, Rac 1, Rag B, Rap 2B, RAPGEFL1, RASGEF1A, RASGEF1C, RGC32, RGD1562043, RGL1, RGS22, RHAMM, Rho A, Rho C, Rho D, Rho F, Rho G, Rho J, Rho T1, Rho V, RHOBTB1, Ribosomal Protein S25, RIC-8A, RIMKLB, RIN3, Rnd1, RNH1, Rock-1, Rock-2, SAMD8, SASPase, SDPR, SEMA4F, SEMA6B, SERINC1, SERINC4, SH2D4A, Sin, Slfn2, SMAP1L, SMG5, Soggy-1, Sphingomyelin Synthase 2, SphK1, SREB3, SRPX, SSc5D, StARD13, StARD9, Stat5a, Stat6, SUR-5, Syndecan-4, T-cadherin, Tβ-4 Y-linked, TBC1D26, TBC1D2B, TC 21, TC10, TDE2L, TEM5, Tenascin-X, Tensin3, TESK1, Testican-2, tetranectin, Thrombospondin 4, TIP-1, TLL1, TMEM184A, TMSL3, Tor1, tropoelastin, TSPAN1, TSPAN6, UBF, V-ATPase D2, V-ATPase F, vanin-2, versican, VgI-4, Vmn1r157, Vmn1r163, VPS13A, VPS4A, VPS4B, VPS51, VR1, VSIG6, WDR54, WDR62, WNK1, XKR6, XKR7, XKR9, Ypk2, ZBTB2, ZDHHC21, ZNF175, and ZXDA.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lysophosphatidic Acid, 5 mg | sc-201053 | 5 mg | $98.00 | |||
Lysophosphatidic Acid, 25 mg | sc-201053A | 25 mg | $341.00 |