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Lysophosphatidic acid (LPA) is an endogenous glycerophospholipid signaling molecule and ligand activator for EDG-2 and EDG-4 (LPA) receptors. Signaling associated with LPA has been reported to stimulate growth of fibroblasts, vascular smooth muscle cells, endothelial cells, and keratinocytes. LPA has been indicated as both a proliferative and anti-apoptotic factor, signaling for Pl3K-mediated regulation of cell activity. LPA has also been described to potentiate acetylchloine receptor currents by G-protein-mediated activation of Ca2+-dependent/independent protein kinase C.
1. Moolenaar, W H., et al., 1995. Lysophosphatidic acid, a multifunctional phospholipid messenger. The Journal of biological chemistry. 270(22): 12949-52. PMID: 7768880
2. Levine, J S., et al., 1997. Lysophosphatidic acid: a novel growth and survival factor for renal proximal tubular cells. The American journal of physiology. 273(4 Pt 2): F575-85. PMID: 9362335
3. Nishizaki, T., et al., 1997. Lysophosphatidic acid potentiates ACh receptor currents by G-protein-mediated activation of protein kinase C. Brain research. Molecular brain research. 50(1-2): 121-6. PMID: 9406926
See how others have used Lysophosphatidic Acid. Click on the entry to view the PubMed entry .
PMID: # 30840161 Olianas, MC.|Dedoni, S.|Onali, P.| et al. 2019. Apoptosis.
PMID: # 30535430 2019. Int. J. Oncol. 54: 515-526.
PMID: # 31145906 Xu, L.|Su, J.|Guo, L.|Wang, S.|Deng, X.|Ma, S.| et al. 2019. Neuropharmacology. 155: 150-161.
PMID: # 31010479 Jobst-Schwan, T.|Hoogstraten, CA.|Kolvenbach, CM.|Schmidt, JM.|Kolb, A.|Eddy, K.|Schneider, R.|Ashraf, S.|Widmeier, E.|Majmundar, AJ.|Hildebrandt, F.| et al. 2019. Kidney Int. 95: 1079-1090.
PMID: # 27754741 Handa, H.|Hashimoto, A.|Hashimoto, S.|Sabe, H.| et al. 2018. Small GTPases. 9: 420-426.
PMID: # 30031609 Lu, S. et al. 2018. Biochem. Biophys. Res. Commun. 503: 1322-1329.
PMID: # 30385786 Deng, Y.|Lu, J.|Li, W.|Wu, A.|Zhang, X.|Tong, W.|Ho, KK.|Qin, L.|Song, H.|Mak, KK.| et al. 2018. Nat Commun. 9: 4564.
PMID: # 29474739 Li, W.|Deng, Y.|Feng, B.|Mak, KK.| et al. 2018. J. Bone Miner. Res. 33: 1183-1195.
PMID: # 29259017 Sun, Z.|Schwenzer, A.|Rupp, T.|Murdamoothoo, D.|Vegliante, R.|Lefebvre, O.|Klein, A.|Hussenet, T.|Orend, G.| et al. 2018. Cancer Res. 78: 950-961.
PMID: # 27081697 Liu, X.|Wang, A.|Liang, X.|Chen, C.|Liu, J.|Zhao, Z.|Wu, H.|Deng, Y.|Wang, L.|Wang, B.|Wu, J.|Liu, F.|Fernandes, SM.|Adamia, S.|Stone, RM.|Galinsky, IA.|Brown, JR.|Griffin, JD.|Zhang, S.|Loh, T.|Zhang, X.|Wang, W.|Weisberg, EL.|Liu, J.|Liu, Q.| et al. 2016. Oncotarget. 7: 32641-51.
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