EPCR Activators
The class of EPCR activators comprises a diverse set of chemical compounds that directly or indirectly modulate the expression and function of Endothelial Protein C Receptor (EPCR). Notably, prostacyclin analogs like Iloprost and Forskolin exemplify direct activators by stimulating the prostacyclin receptor and adenylyl cyclase, respectively. These compounds elevate intracellular cAMP levels, serving as secondary messengers that activate downstream pathways intricately linked to EPCR, thereby providing a precise means of inducing cellular responses associated with EPCR activation. Cyclic AMP (cAMP) itself, as exemplified by direct administration or the use of analogs like 8-CPT-cAMP, stands as a central player in EPCR activation. Elevated cAMP levels directly activate various signaling cascades, offering a straightforward mechanism for influencing EPCR expression and function. Additionally, compounds such as PGE1, Isoproterenol, and Epinephrine exert their activating effects by engaging specific receptors and subsequently increasing cAMP levels, providing targeted approaches for inducing cellular responses associated with EPCR.
Furthermore, the class includes modulators like FTY720 and Milrinone, which act on Sphingosine-1-phosphate (S1P) receptors and PDE3, respectively. These compounds influence downstream signaling pathways, directly impacting EPCR expression and function. Their mechanisms involve the modulation of cellular responses linked to EPCR, demonstrating the multifaceted nature of EPCR activation. In summary, the class of EPCR activators encompasses a repertoire of chemical compounds that intricately modulate cellular pathways associated with EPCR. These activators act through well-defined mechanisms, offering a nuanced understanding of how specific biochemical and cellular pathways directly or indirectly influence the expression and activity of EPCR.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Iloprost | 78919-13-8 | sc-205349 sc-205349A | 500 µg 1 mg | $155.00 $269.00 | ||
Iloprost, a prostacyclin analog, activates the prostacyclin receptor, leading to increased cAMP levels. Elevated cAMP can activate downstream pathways influencing EPCR expression and function, providing a direct means of modulating EPCR activity and cellular responses associated with EPCR. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin stimulates adenylyl cyclase, resulting in elevated cAMP levels. The increased cAMP serves as a secondary messenger, activating pathways that can modulate EPCR expression and function directly. Forskolin-mediated cAMP elevation provides a specific mechanism for activating cellular responses associated with EPCR. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
Cyclic AMP itself, as a secondary messenger, can directly activate various downstream pathways. Elevating cellular cAMP levels through direct administration can lead to the activation of signaling cascades influencing EPCR, providing a straightforward approach for modulating EPCR expression and function. | ||||||
PGE1 (Prostaglandin E1) | 745-65-3 | sc-201223 sc-201223A | 1 mg 10 mg | $31.00 $145.00 | 16 | |
Prostaglandin E1 (PGE1) activates the prostaglandin E receptor, leading to increased cAMP levels. The resulting rise in cAMP serves as a signaling mediator, activating pathways that directly modulate EPCR expression and function. PGE1 provides a specific means of eliciting cellular responses associated with EPCR through its action on downstream pathways. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a non-selective beta-adrenergic receptor agonist that activates adenylyl cyclase, increasing cellular cAMP levels. The subsequent elevation in cAMP can directly influence EPCR expression and function by activating downstream pathways associated with EPCR modulation. Isoproterenol provides a targeted approach for activating cellular responses linked to EPCR. | ||||||
8-CPT-cAMP | 93882-12-3 | sc-201569 sc-201569A | 20 mg 100 mg | $87.00 $316.00 | 19 | |
8-CPT-cAMP is a cell-permeable cAMP analog that directly activates cAMP-dependent signaling pathways. By mimicking the effects of cAMP, 8-CPT-cAMP provides a specific means of modulating EPCR expression and function, influencing downstream cellular responses associated with EPCR through the direct activation of cAMP-dependent pathways. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine acts on adrenergic receptors, leading to increased cAMP levels through adenylyl cyclase activation. The resulting rise in cAMP serves as a secondary messenger, directly activating pathways that modulate EPCR expression and function. Epinephrine provides a specific means of influencing cellular responses associated with EPCR through its action on adrenergic receptors and downstream pathways. | ||||||
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $109.00 $322.00 | 3 | |
Cilostazol, a phosphodiesterase 3 (PDE3) inhibitor, prevents cAMP degradation, resulting in elevated cAMP levels. The sustained increase in cAMP can directly activate pathways that modulate EPCR expression and function, providing a specific mechanism for influencing cellular responses associated with EPCR through the inhibition of cAMP degradation. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $33.00 $77.00 $120.00 | 14 | |
FTY720 is a sphingosine-1-phosphate (S1P) receptor modulator that influences downstream signaling pathways. Activation of S1P receptors by FTY720 can directly modulate EPCR expression and function by affecting cellular responses associated with EPCR. FTY720 provides a specific means of influencing EPCR through its action on S1P receptors and related pathways. | ||||||
Milrinone | 78415-72-2 | sc-201193 sc-201193A | 10 mg 50 mg | $165.00 $697.00 | 7 | |
Milrinone, a PDE3 inhibitor, prevents cAMP degradation, leading to increased cAMP levels. The sustained elevation in cAMP can directly activate pathways that modulate EPCR expression and function, providing a specific mechanism for influencing cellular responses associated with EPCR through the inhibition of cAMP degradation. | ||||||