Molecular structure of 8-CPT-cAMP, CAS Number: 93882-12-3
8-CPT-cAMP (CAS 93882-12-3)
See product citations (19)
Alternate Names:
8-(4-Chlorophenylthio)-adenosine-3′,5′-cyclic monophosphate, sodium salt
Application:
8-CPT-cAMP is an efficient activator of cGK and cAMP-PK, and inhibitor of PDE
CAS Number:
93882-12-3
Purity:
≥96%
Molecular Weight:
493.79
Molecular Formula:
C16H14ClN5O6PS•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
8-CPT-cAMP is an efficient activator of cGKI (cyclic-GMP-dependent protein kinase) and PKA (cAMP-PK). Additionally, 8-CPT-cAMP is a robust inhibitor of PDE (cyclic GMP-specific phosphodiesterase) (IC50= 0.9 muM). cGMP-inhibited phosphodiesterase and Ca2+/calmodulin-dependent phosphodiesterase have been reported to hydrolyze 8-CPT-cAMP. 8-CPT-cAMP has been used in studies to analyze the signal-transduction pathways initiated by cAMP-PK and cGMP-PK. Research indicates that 8-CPT-cAMP can inhibit thrombin-induced phosphorylation mediated by protein kinase C and myosin light chain kinase.
8-CPT-cAMP (CAS 93882-12-3) References
- Activation of the cAMP signaling pathway increases apoptosis in human B-precursor cells and is associated with downregulation of Mcl-1 expression. | Myklebust, JH., et al. 1999. J Cell Physiol. 180: 71-80. PMID: 10362019
- cAMP-induced stellation in primary astrocyte cultures with regional heterogeneity. | Won, CL. and Oh, YS. 2000. Brain Res. 887: 250-8. PMID: 11134613
- Effects of 8-cpt-cAMP on the epithelial sodium channel expressed in Xenopus oocytes. | Chraïbi, A., et al. 2001. J Membr Biol. 183: 15-23. PMID: 11547348
- [In vitro study of the effects of arsenic trioxide combined with 8-CPT-cAMP on differentiation induction in retinoic acid resistant acute promyelocytic leukemia cells]. | Zhu, Q., et al. 2003. Zhonghua Xue Ye Xue Za Zhi. 24: 6-9. PMID: 12679001
- Role of cGMP and cGMP-dependent protein kinase in nitrovasodilator inhibition of agonist-evoked calcium elevation in human platelets. | Geiger, J., et al. 1992. Proc Natl Acad Sci U S A. 89: 1031-5. PMID: 1310537
- 8-(4-Chlorophenyl)thio-cyclic AMP is a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA). | Connolly, BJ., et al. 1992. Biochem Pharmacol. 44: 2303-6. PMID: 1335252
- Characterization of Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole- 3',5'-monophosphorothioate (Sp-5,6-DCl-cBiMPS) as a potent and specific activator of cyclic-AMP-dependent protein kinase in cell extracts and intact cells. | Sandberg, M., et al. 1991. Biochem J. 279 (Pt 2): 521-7. PMID: 1659381
- [cAMP analogue 8-CPT-cAMP inducing differentiation in the M2b subtype of acute myeloid leukemia cell line Kasumi-1]. | Zhu, Q., et al. 2008. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 16: 44-7. PMID: 18315898
- Involvement of NADPH-dependent and cAMP-PKA sensitive H+ channels in the chorda tympani nerve responses to strong acids. | DeSimone, JA., et al. 2011. Chem Senses. 36: 389-403. PMID: 21339339
- Quantitative proteomics analysis of the cAMP/protein kinase A signaling pathway. | Guo, Y., et al. 2012. Biochemistry. 51: 9323-32. PMID: 23110364
- 8-CPT-cAMP/all-trans retinoic acid targets t(11;17) acute promyelocytic leukemia through enhanced cell differentiation and PLZF/RARα degradation. | Jiao, B., et al. 2013. Proc Natl Acad Sci U S A. 110: 3495-500. PMID: 23382200
- Cyclic-AMP regulates postnatal development of neural and behavioral responses to NaCl in rats. | Qian, J., et al. 2017. PLoS One. 12: e0171335. PMID: 28192441
- cAMP induces cell apoptosis in multiple myeloma and overcomes bortezomib resistance. | Wang, Y., et al. 2018. Am J Cancer Res. 8: 16-29. PMID: 29416917
- The P2RY12 receptor promotes VSMC-derived foam cell formation by inhibiting autophagy in advanced atherosclerosis. | Pi, S., et al. 2021. Autophagy. 17: 980-1000. PMID: 32160082
- 8-bromo-cAMP and 8-CPT-cAMP increase the density of beta-adrenoceptors in hepatocytes by a mechanism not mimicking the effect of cAMP. | Sandnes, D., et al. 1996. Pharmacol Toxicol. 79: 15-22. PMID: 8841091
Inhibitor of:
cGKI, and PDE.Activator of:
2310007A19Rik, 2310007B03Rik, Adenovirus-5 E1A, ARHGEF5L, ATP11C, C330027C09Rik, CARD 10, CASK, CEP72, connexin 23, connexin 25, connexin 40.1, COPD, EG436049, EG546901, Epac, EPCR, FAM18B, FOXN2, G0S2, Gm884, GPR7, GRASP55, GRK 5, KIAA12117/1/2014C530008M17Rik, KIF18B, MBNL2, MIST1, nardilysin, Nectin 2, Olfr815, Olfr816, Olfr818, Olfr820, Olfr821, Olfr822, Olfr823, Olfr866, Olfr94, Olfr943, Olfr944, OTTMUSG00000010332, OTTMUSG00000010432, Paralemmin 2, PDZ-GEF1, Pellino 1, PKA, R7BP, Rap1GAP, RasGRP3, Repac, RGD1562043, RGS10, ST2, TIM-1, TMEM229A, and TTC9.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
8-CPT-cAMP, 20 mg | sc-201569 | 20 mg | $87.00 | |||
8-CPT-cAMP, 100 mg | sc-201569A | 100 mg | $316.00 |