EPCR Antibody (RCR-49): sc-53982

EPCR Antibody (RCR-49) is a rat monoclonal IgG2a antibody that detects EPCR protein of human origin by immunoprecipitation (IP) and flow cytometry (FCM). Anti-EPCR antibody (RCR-49) is available in both non-conjugated and various conjugated forms, including agarose, phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. The endothelial Protein C receptor (EPCR) plays a crucial role in regulating coagulation and inflammation by enhancing Protein C activation, which is vital for maintaining hemostatic balance. Located predominantly on endothelial cells in large blood vessels, particularly in the heart and lungs, EPCR binds to both Protein C and activated Protein C with high affinity, facilitating the anticoagulant pathway that prevents excessive clot formation. The gene encoding EPCR is situated on human chromosome 20q11.2, and EPCR expression is essential for proper vascular system functioning, as EPCR helps modulate thrombin activity and protect against thrombosis. Additionally, soluble forms of EPCR in plasma may act as inhibitors of the membrane-bound receptor, further influencing the anticoagulant response. Understanding EPCR function and significance is critical for exploring therapeutic strategies in conditions associated with dysregulated coagulation and inflammation.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

EPCR Antibody (RCR-49) References:

1. Is EPCR a multi-ligand receptor? Pros and cons.  |  Montes, R., et al. 2012. Thromb Haemost. 107: 815-26. PMID: 22318610
2. Regulation of long-term repopulating hematopoietic stem cells by EPCR/PAR1 signaling.  |  Gur-Cohen, S., et al. 2016. Ann N Y Acad Sci. 1370: 65-81. PMID: 26928241
3. EPCR promotes breast cancer progression by altering SPOCK1/testican 1-mediated 3D growth.  |  Perurena, N., et al. 2017. J Hematol Oncol. 10: 23. PMID: 28103946
4. EPCR expression marks UM171-expanded CD34+ cord blood stem cells.  |  Fares, I., et al. 2017. Blood. 129: 3344-3351. PMID: 28408459
5. Endothelial Protein C Receptor (EPCR), Protease Activated Receptor-1 (PAR-1) and Their Interplay in Cancer Growth and Metastatic Dissemination.  |  Wojtukiewicz, MZ., et al. 2019. Cancers (Basel). 11: PMID: 30626007
6. EPCR knockout: inflaming the discussion.  |  Monroe, D. and Hoffman, M. 2020. Blood. 135: 2201-2202. PMID: 32556134
7. EPCR-PAR1 biased signaling regulates perfusion recovery and neovascularization in peripheral ischemia.  |  Bochenek, ML., et al. 2022. JCI Insight. 7: PMID: 35700057
8. Differential expression of endothelial protein C receptor (EPCR) in hematopoietic stem and multipotent progenitor cells in young and old mice.  |  Lin, DS. and Trumpp, A. 2023. Cells Dev. 174: 203843. PMID: 37080459
9. The APC-EPCR-PAR1 axis in sickle cell disease.  |  Ramadas, N. and Sparkenbaugh, EM. 2023. Front Med (Lausanne). 10: 1141020. PMID: 37497271
10. Structural vulnerability in EPCR suggests functional modulation.  |  Erausquin, E., et al. 2024. Sci Rep. 14: 2591. PMID: 38297105

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-EPCR Antibody (RCR-49) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-EPCR Antibody (RCR-49) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

EPCR Antibody (RCR-49) Specifications

Alternate Product Name: EPCR

Product Clone Name: RCR-49

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids:

Epitope Target: EPCR

Epitope Species: human

Product Reactivity/Detection:

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IP, FCM

Vialing Information: Each vial contains 200 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for EPCR Antibody (RCR-49): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, PE: Phycoerythrin