Gm806 Activators
NUT family member 2 activators encompass a range of compounds that influence cellular pathways leading to the activation of this protein. Forskolin, through cAMP elevation, activates PKA, which in turn can phosphorylate CREB, a transcription factor that promotes the activation of NUT family member 2. Similarly, caffeine, by inhibiting the degradation of cAMP, indirectly enhances the activation of NUT family member 2 through sustained PKA signaling. db-cAMP, a synthetic analog of cAMP, also activates PKA, bolstering the phosphorylation of key transcription factors that are integral in NUT family member 2 activation.
Other compounds, such as EGCG and curcumin, address the epigenetic landscape, with EGCG inhibiting DNA methyltransferases, leading to the hypomethylation and subsequent activation of genes important for NUT family member 2 function, while curcumin activates PKD1, which phosphorylates transcription factors associated with NUT family member 2 activation. Resveratrol's activation of SIRT1 and sulforaphane's activation of Nrf2 both result in the modulation of transcription factors and coactivators that enhance the activation of NUT family member 2. Quercetin's inhibition of PI3K, genistein's inhibition of tyrosine kinases, and capsaicin's activation of TRPV1 also create a cascade of intracellular events culminating in the functional activation of NUT family member 2. Moreover, retinoic acid and pioglitazone each bind to specific receptors that act as transcription factors to promote the activation of genes that upregulate NUT family member 2 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG inhibits DNA methyltransferases, leading to hypomethylation of genes that are crucial for NUT family member 2 activation, thus enhancing its functional activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin activates protein kinase D1 (PKD1), which can phosphorylate and activate transcription factors that enhance the expression of genes related to the activation of NUT family member 2. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates sirtuin 1 (SIRT1), which then deacetylates transcription factors and coactivators to stimulate genes that upregulate the activation of NUT family member 2. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane activates Nrf2, which translocates to the nucleus and binds to antioxidant response elements (ARE) in the promoters of genes, leading to the activation of NUT family member 2. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin inhibits phosphoinositide 3-kinases (PI3K), which leads to alterations in the AKT signaling pathway, enhancing the activation of NUT family member 2. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine inhibits phosphodiesterases, thus preventing cAMP breakdown, which enhances PKA activity that is implicated in the activation of NUT family member 2. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein inhibits tyrosine kinases, leading to altered phosphorylation patterns on proteins that are involved in the activation pathway of NUT family member 2. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin activates TRPV1, which can lead to an increase in intracellular calcium, activating calmodulin-dependent kinases that enhance activation of NUT family member 2. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid binds to its receptors, which act as transcription factors that can enhance gene expression related to the activation of NUT family member 2. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
Pioglitazone activates peroxisome proliferator-activated receptor gamma (PPARγ), which can upregulate genes that enhance the activation of NUT family member 2. | ||||||