Gm806 Inhibitors
The chemical class known as Nutm2 Inhibitor includes compounds that modulate chromatin dynamics and gene expression by targeting enzymes and proteins that interact with chromatin, rather than directly inhibiting NUTM2 itself. These compounds function by inhibiting the activity of bromodomain-containing proteins, histone acetyltransferases, and histone deacetylases, thereby impacting the epigenetic regulation associated with NUTM2.
BET bromodomain inhibitors such as JQ1, I-BET762, CPI-0610, OTX015, GSK525762A, Bromosporine, and RVX-208 act by preventing the reading of acetylation marks on histones. This action can disrupt the function of proteins like BRD4, which are known to interact with NUTM2, thus affecting the transcriptional regulation of genes associated with NUTM2. On the other hand, inhibitors of histone acetyltransferases like A-485 and C646 can reduce the acetylation levels of histones, potentially altering the chromatin landscape with which NUTM2 interacts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
Inhibits the BET bromodomain proteins, disrupting their interaction with acetylated histones, which may affect NUTM2-associated chromatin changes. | ||||||
GSK 525762A | 1260907-17-2 | sc-490339 sc-490339A sc-490339B sc-490339C sc-490339D | 5 mg 10 mg 50 mg 100 mg 1 g | $300.00 $540.00 $940.00 $1680.00 $5900.00 | ||
Another BET bromodomain inhibitor that can disrupt the reading of acetylation marks, potentially altering NUTM2's role in chromatin. | ||||||
CPI-0610 | 1380087-89-7 | sc-507490 | 10 mg | $495.00 | ||
BET bromodomain inhibitor that can alter transcription regulation, potentially affecting NUTM2's function in gene expression. | ||||||
(S)-2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-hydroxyphenyl)acetamide | 202590-98-5 | sc-501130 | 2.5 mg | $330.00 | ||
Targets BET bromodomains, potentially affecting the chromatin interactions of NUTM2. | ||||||
A-485 | 1889279-16-6 | sc-507493 | 5 mg | $275.00 | ||
A potent and selective inhibitor of the p300/CBP histone acetyltransferase which can alter acetylation, potentially impacting NUTM2's chromatin modulation. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $265.00 $944.00 | 5 | |
A competitive inhibitor of p300 HAT activity, which may affect histone acetylation and thus NUTM2's involvement in chromatin structure. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
A selective inhibitor of class I histone deacetylases, potentially affecting chromatin structure and gene expression related to NUTM2. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
A histone deacetylase inhibitor that can change chromatin dynamics, potentially influencing NUTM2's role in gene regulation. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
A potent pan-histone deacetylase inhibitor, which may affect chromatin architecture and potentially NUTM2's activity. | ||||||
RVX 208 | 1044870-39-4 | sc-472700 | 10 mg | $340.00 | ||
A small molecule BET inhibitor that can modulate chromatin structure, possibly affecting NUTM2's role in gene expression. | ||||||