ZSCAN4C Activators
Zinc finger and SCAN domain containing 4C Activators encompass a diverse set of chemical compounds that facilitate the activation of this transcription factor through various intracellular signaling pathways and modifications in chromatin structure. Forskolin, by raising intracellular cAMP levels, activates protein kinase A, which in turn can enhance the functional activity of zinc finger and SCAN domain containing 4C by influencing the phosphorylation state of proteins that interact with or regulate its activity. Similarly, PMA, through activation of PKC, may phosphorylate transcriptional regulators that boost the functional activity of zinc finger and SCAN domain containing 4C, thereby promoting its role in gene expression.
Compounds such as 5-Azacytidine and Trichostatin A act epigenetically by reducing DNA methylation and increasing histone acetylation, respectively, leading to a more transcriptionally activechromatin environment conducive to the binding of zinc finger and SCAN domain containing 4C to its target DNA sequences. In parallel, LiCl and retinoic acid can modulate the levels and activity of transcriptional coactivators, such as β-catenin and retinoic acid receptors, which can physically interact with zinc finger and SCAN domain containing 4C to enhance its transcriptional activity. The proteasome inhibitor MG132 can indirectly affect the protein's activity by stabilizing the transcriptional machinery and co-regulatory proteins that are essential for the optimal function of zinc finger and SCAN domain containing 4C. Additionally, small molecules like Epigallocatechin gallate and SB431542 can induce changes in the methylation status of DNA and TGF-β signaling, respectively, which can lead to an upregulation of zinc finger and SCAN domain containing 4C activity by altering the transcriptional landscape in which it operates. Bay K8644 and A23187, by increasing intracellular calcium concentrations, can activate calcium-sensitive proteins that may influence the transcriptional regulatory functions of zinc finger and SCAN domain containing 4C, promoting its role in gene expression and cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which can phosphorylate transcription factors or cofactors involved in the regulation of zinc finger and SCAN domain containing 4C, leading to its enhanced functional activity. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin raises intracellular calcium levels, which can activate calcium-dependent signaling pathways, including calcineurin and CaMK, that may enhance the functional activity of zinc finger and SCAN domain containing 4C through altered transcription factor activity. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine inhibits DNA methyltransferases, leading to reduced methylation and more open chromatin. This can enhance the functional activity of zinc finger and SCAN domain containing 4C by increasing its access to chromatin and its target genes. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is an inhibitor of histone deacetylases (HDACs), which can lead to a more relaxed chromatin structure and potentially enhance the functional activity of zinc finger and SCAN domain containing 4C by increasing its binding to target gene promoters. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid acts as a ligand for retinoic acid receptors (RARs), which can heterodimerize with other transcription factors and enhance the functional activity of zinc finger and SCAN domain containing 4C by promoting transcriptional activation of its target genes. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 inhibits the proteasome, leading to the accumulation of regulatory proteins that may enhance the functional activity of zinc finger and SCAN domain containing 4C by stabilizing transcription factor complexes that activate its target genes. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate can inhibit DNA methyltransferases, potentially leading to hypomethylation and activation of genes. This can enhance the functional activity of zinc finger and SCAN domain containing 4C by increasing its genomic access. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB431542 is an inhibitor of the TGF-β type I receptor ALK5, which can lead to altered SMAD signaling. This altered signaling may enhance the functional activity of zinc finger and SCAN domain containing 4C through changes in transcriptional regulation of target genes. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $84.00 $196.00 $817.00 | ||
Bay K8644 acts as a calcium channel agonist, which can increase intracellular calcium levels and activate calcium-dependent proteins that may enhance the functional activity of zinc finger and SCAN domain containing 4C via modulation of transcription factor activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels, potentially enhancing the functional activity of zinc finger and SCAN domain containing 4C through activation of calcium-dependent signaling pathways affecting gene expression. | ||||||