ZNF6 Activators
ZNF6 activators include compounds that stimulate adenylate cyclase or act as beta-adrenergic agonists, resulting in increased cAMP levels within the cell. This elevation in cAMP activates protein kinase A (PKA), which then phosphorylates various substrates, including transcription factors that may interact with and enhance the functional activity of ZNF6. Similarly, the activation of protein kinase C (PKC) through certain diacylglycerol analogs leads to the phosphorylation of target proteins, potentially including ZNF6, which could augment its role in transcriptional regulation. Additionally, agents that increase intracellular calcium levels, either by forming complexes with calcium ions or by acting as calcium ionophores, can initiate a cascade of events activating calcium-dependent protein kinases. These kinases have the potential to phosphorylate and increase the functional activity of ZNF6, illustrating another mechanism by which ZNF6 activity can be modulated.
Other mechanisms of ZNF6 activation involve the modulation of gene expression through the alteration of chromatin structure or DNA methylation. Compounds that inhibit histone deacetylases or DNA methyltransferases can lead to a more relaxed chromatin state or hypomethylation of gene promoters, respectively, potentially resulting in enhanced transcription of the ZNF6 gene. Moreover, the inhibition of glycogen synthase kinase-3 or the activation of the MAPK/ERK pathway through growth factor signaling can stabilize and activate transcription factors that increase the expression of ZNF6.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Directly stimulates adenylate cyclase, increasing cAMP levels. Elevated cAMP enhances protein kinase A (PKA) activity, which can phosphorylate ZNF6, leading to its functional activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C (PKC), which can phosphorylate target proteins including ZNF6, potentially enhancing its transcriptional activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Increases intracellular calcium levels by forming complexes with calcium ions, which can activate calcium-dependent protein kinases that may phosphorylate and activate ZNF6. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Acts as a ligand for nuclear receptors that regulate gene expression, potentially upregulating the expression of ZNF6 through retinoic acid response elements. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Inhibits glycogen synthase kinase-3 (GSK-3), which may lead to stabilization and activation of transcription factors that enhance ZNF6 expression. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Activates the PI3K/AKT signaling pathway, which may result in increased transcription and activity of proteins including ZNF6 through downstream effects. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Histone deacetylase inhibitor that can alter chromatin structure, potentially enhancing the transcription of ZNF6 by making its promoter more accessible. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
A histone deacetylase inhibitor that can increase the expression of genes by changing chromatin conformation, possibly leading to increased ZNF6 expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that can reactivate silenced genes, potentially resulting in the upregulation of ZNF6 expression through hypomethylation of its promoter. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
A beta-adrenergic agonist that increases intracellular cAMP, which can enhance PKA activity and potentially lead to the phosphorylation and activation of ZNF6. | ||||||