ZNF530 Activators
ZNF530 can facilitate its activation through various cellular signaling pathways. Phorbol 12-myristate 13-acetate (PMA) is a potent activator of protein kinase C (PKC), which phosphorylates a multitude of proteins, including those that may interact with ZNF530. Similarly, forskolin elevates cyclic AMP (cAMP) levels by activating adenylate cyclase, which in turn activates protein kinase A (PKA). PKA then phosphorylates transcription factors and other proteins that can engage ZNF530. Dibutyryl-cAMP, a cAMP analog, also activates PKA, leading to a similar cascade of phosphorylation events. Isoproterenol, a beta-adrenergic agonist, increases cAMP levels as well, further contributing to PKA activation and subsequent interactions with ZNF530.
Ionomycin and A23187 are calcium ionophores that raise intracellular calcium levels, which can activate calcium-dependent proteins that interact with ZNF530. Bay K8644, an L-type calcium channel agonist, similarly promotes calcium influx, potentially enhancing ZNF530 activity. Lithium chloride's inhibition of GSK-3 leads to β-catenin stabilization, which may then translocate to the nucleus and engage ZNF530. Retinoic acid, by binding to its receptors, can affect gene expression and might modify ZNF530 activity through direct or indirect interactions. Epidermal Growth Factor (EGF) stimulates its receptor, leading to the activation of the MAPK/ERK pathway, which can result in the phosphorylation of proteins that associate with ZNF530. Lastly, Trichostatin A and Sodium butyrate, both histone deacetylase inhibitors, can relax chromatin structure, thereby enhancing the accessibility of transcription factors to DNA and possibly facilitating the activation of ZNF530.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate, also known as PMA, activates protein kinase C (PKC) which is involved in signaling pathways that lead to the activation of a variety of proteins, including zinc finger proteins such as ZNF530, by phosphorylation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels, which in turn activates PKA. PKA can phosphorylate transcription factors and other proteins that may interact with and activate ZNF530. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can activate calcium-dependent proteins and potentially enhance the activation of ZNF530 through calcium signaling pathways. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid binds to retinoic acid receptors (RARs) which can heterodimerize with other nuclear receptors and may interact with ZNF530, leading to its activation through conformational changes or recruitment to specific DNA sites. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3, which can lead to the stabilization and activation of β-catenin. Activated β-catenin can enter the nucleus and potentially interact with ZNF530, leading to functional activation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cAMP analog that activates PKA. Activated PKA can phosphorylate substrates that might interact with ZNF530, thereby promoting its activation. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases cAMP levels, leading to PKA activation. PKA may then phosphorylate proteins that can interact with and activate ZNF530. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor, which can lead to a more relaxed chromatin state and enhance the access of transcription factors and coactivators to DNA, potentially facilitating the activation of ZNF530. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate, another histone deacetylase inhibitor, may similarly induce chromatin remodeling, thus possibly promoting the recruitment and activation of ZNF530 to specific DNA regions. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
Bay K8644 is an L-type calcium channel agonist, which increases calcium influx and thereby could enhance the activation of ZNF530 through calcium-dependent signaling pathways. | ||||||