ZNF434 Inhibitors
Disulfiram and SAHA act by modifying the acetylation status of histones, thereby affecting the binding affinity and regulatory capacity of ZNF434 on its target genes. Furthermore, RG108, 5-Azacytidine, and Decitabine are agents that target the methylation status of DNA, a key epigenetic mark that ZNF434 could potentially recognize or that could influence the expression of genes regulated by ZNF434. By altering DNA methylation patterns, these inhibitors can change the transcriptional programs that ZNF434 is involved in.
The BET bromodomain inhibitors JQ1 and I-BET151, along with C646, a p300/CBP histone acetyltransferase inhibitor, influence the protein interactions and chromatin modifications necessary for transcriptional regulation. These changes can affect the recruitment of ZNF434 to its target sites or its ability to modulate gene expression. Olaparib's role as a PARP inhibitor suggests it can modulate DNA repair pathways, potentially impacting ZNF434's involvement in DNA damage responses. Lastly, histone methylation modifiers like GSK343, BRD4770, and UNC1999 can change the chromatin landscape, which is integral to ZNF434's transcriptional regulation.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Aldehyde dehydrogenase inhibitor; can alter acetylation status, potentially affecting ZNF434 DNA-binding activity. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
DNA methyltransferase inhibitor; can change DNA methylation, potentially altering ZNF434 target gene expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Histone deacetylase inhibitor; can increase histone acetylation, potentially modulating ZNF434-mediated transcription. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
BET bromodomain inhibitor; can displace bromodomain proteins from chromatin, potentially affecting ZNF434 interaction with transcriptional machinery. | ||||||
I-BET 151 Hydrochloride | 1300031-49-5 (non HCl Salt) | sc-391115 | 10 mg | $450.00 | 2 | |
BET bromodomain inhibitor; similar to JQ1, can disrupt protein-protein interactions necessary for ZNF434 function. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
DNA methyltransferase inhibitor; can lead to DNA demethylation, potentially affecting ZNF434's genomic targeting. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
DNA methyltransferase inhibitor; can induce hypomethylation of DNA, potentially altering ZNF434's ability to bind DNA. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
PARP inhibitor; can affect DNA repair processes, potentially influencing ZNF434-related DNA damage responses. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $265.00 $944.00 | 5 | |
p300/CBP histone acetyltransferase inhibitor; can affect chromatin structure, potentially altering ZNF434's access to DNA. | ||||||
GSK343 | 1346704-33-3 | sc-397025 sc-397025A | 5 mg 25 mg | $151.00 $461.00 | 1 | |
EZH2 histone methyltransferase inhibitor; can lead to reduced histone methylation, potentially influencing ZNF434-mediated transcriptional repression. | ||||||