ZNF346 Activators
ZNF346 activators have been identified that influence its function through a variety of cellular mechanisms, enhancing the protein's transcriptional activity. Certain compounds directly increase the intracellular levels of cyclic AMP, a secondary messenger that activates protein kinase A. The activated kinase can then phosphorylate ZNF346, which enhances its DNA-binding affinity and transcriptional activity. Other activators function by inhibiting the degradation of cAMP, thereby amplifying the signaling cascade that leads to phosphorylation and subsequent activation of ZNF346. Additionally, there are activators that increase intracellular calcium concentrations, which activate calcium/calmodulin-dependent kinases. These kinases can also phosphorylate transcription factors like ZNF346, potentially bolstering its functional activity.
Some activators target the protein kinase C pathway, either by direct stimulation or by altering the balance of kinase activities, which could lead to indirect mechanisms that enhance the activity of ZNF346. Other molecules have been shown to inhibit pathways that repress transcription factors, thus indirectly increasing the transcriptional activity of ZNF346 by reducing competitive inhibition or removing co-repressor complexes from gene promoters. Furthermore, certain compounds inhibit histone deacetylases, leading to an open chromatin structure and improved accessibility for transcription factors such as ZNF346 to their DNA targets.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Adenylyl cyclase activator that increases intracellular cyclic AMP levels, leading to the activation of protein kinase A (PKA). PKA can phosphorylate ZNF346, thereby enhancing its DNA-binding activity and transcriptional function. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
A beta-adrenergic agonist that activates adenylyl cyclase via G protein-coupled receptor signaling, increasing cAMP levels and subsequently activating PKA which can phosphorylate and activate ZNF346. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
A non-selective phosphodiesterase inhibitor that prevents the degradation of cAMP, potentiating the effect of cAMP-dependent PKA activation, which can lead to the phosphorylation and activation of ZNF346. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
A calcium ionophore that increases intracellular calcium concentrations, activating calmodulin-dependent kinase (CaMK), which can phosphorylate transcription factors like ZNF346, potentially enhancing its function. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
A potent activator of protein kinase C (PKC) that can modulate transcription factors through phosphorylation. PKC-mediated phosphorylation may increase the transcriptional activity of ZNF346. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A calcium ionophore that raises intracellular calcium levels, triggering CaMK activation which could phosphorylate and increase the activity of ZNF346. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
A cAMP analog that is resistant to degradation by phosphodiesterases, directly activating PKA, and thereby potentially leading to the phosphorylation and activation of ZNF346. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
A selective inhibitor of phosphodiesterase 5 (PDE5) that enhances cGMP levels, indirectly influencing the cAMP pathway and possibly leading to PKA-mediated activation of ZNF346. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $88.00 $311.00 | 17 | |
A selective inhibitor of PKC that can alter the balance of kinase activities within the cell, potentially leading to compensatory mechanisms that activate ZNF346. | ||||||
Andrographolide | 5508-58-7 | sc-205594 sc-205594A | 50 mg 100 mg | $15.00 $39.00 | 7 | |
An inhibitor of NF-kB activation that may enhance the transcriptional activity of ZNF346 by alleviating competitive binding or co-repressor recruitment to shared target genes. | ||||||