ZNF285A Activators
ZNF285A can influence the activity of this transcription factor through various intracellular signaling pathways. Forskolin, by directly stimulating adenylyl cyclase, leads to an increase in cellular cAMP levels, which, in turn, activates protein kinase A (PKA). The activation of PKA can result in the phosphorylation of ZNF285A, thereby potentially enhancing its DNA-binding activity. Similarly, dbcAMP, a cell-permeable analog of cAMP, activates the same cAMP-dependent pathways, leading to the activation of PKA and subsequent phosphorylation of ZNF285A, promoting its transcriptional activity. PMA, on the other hand, acts through protein kinase C (PKC), known for its role in phosphorylating various substrates, including transcription factors. PKC-mediated phosphorylation can modify the function and activity of ZNF285A, potentially altering its conformation and how it interacts with other proteins.
Ionomycin and A23187, both calcium ionophores, increase intracellular calcium levels, which can activate calcium-dependent signaling pathways such as calmodulin-dependent kinase (CaMK) pathways. These pathways can phosphorylate ZNF285A, integrating it into the calcium-mediated regulatory network. Epigallocatechin gallate (EGCG) is known to activate multiple signal transduction pathways, including those involving MAPKs, which can lead to the phosphorylation of transcription factors like ZNF285A. Spermine, through its modulation of ion channel activity, might influence intracellular signaling cascades that have an effect on the modulation of transcription factors, including the activation of ZNF285A. LY294002, a PI3K inhibitor, can lead to the activation of alternative pathways that might result in the activation of ZNF285A. SB203580, while primarily a p38 MAPK inhibitor, can also activate alternative signaling pathways, which might lead to the activation of ZNF285A. Okadaic Acid, a potent inhibitor of protein phosphatases, can lead to increased phosphorylation levels and activation of ZNF285A. Trichostatin A, as a histone deacetylase inhibitor, can facilitate ZNF285A's access to DNA by promoting a more open chromatin structure, enabling ZNF285A to bind to DNA more effectively.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate various substrates involved in signal transduction pathways. PKC-mediated phosphorylation can alter the function and activity of transcription factors, potentially including ZNF285A, by changing their conformation, localization, or interaction with other proteins. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels. Elevated calcium can activate calcium-dependent signaling pathways, such as calmodulin-dependent kinase (CaMK) pathways, which may then phosphorylate and activate ZNF285A as part of a broader regulatory network affecting DNA binding and transcriptional regulation. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
Dibutyryl cyclic AMP is a cell-permeable cAMP analog that activates cAMP-dependent pathways, including the activation of PKA. PKA activation can lead to the phosphorylation of transcription factors, which might include ZNF285A, thereby enhancing its transcriptional activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Calcimycin is another calcium ionophore that increases intracellular calcium concentration, thus activating calcium-dependent signaling pathways. Through these pathways, ZNF285A may be phosphorylated and activated as part of a response to altered calcium homeostasis. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG has been shown to activate several signal transduction pathways, such as those involving MAPKs. MAPK activation can lead to downstream phosphorylation of transcription factors, potentially including ZNF285A, thereby enhancing its transcriptional regulatory functions. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $61.00 $196.00 $277.00 $901.00 | 1 | |
Spermine, a polyamine, can modulate ion channel activity and may influence intracellular signaling cascades that involve the modulation of transcription factors. Through such pathways, spermine can activate nuclear factors like ZNF285A by promoting their binding affinity or stability within the nucleus. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor, but paradoxically, inhibition of PI3K can lead to compensatory activation of other pathways that might result in the activation of transcription factors such as ZNF285A through feedback loops or cross-talk between signaling pathways. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
Although SB203580 is primarily known as a p38 MAPK inhibitor, it can activate alternative signaling pathways as a compensatory mechanism, which might lead to activation of transcription factors like ZNF285A through upstream kinase activity or altered protein-protein interactions. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation levels of many proteins. This can result in the activation of transcription factors such as ZNF285A due to reduced dephosphorylation rates, promoting their active state. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $108.00 $169.00 $295.00 $561.00 $835.00 | 2 | |
8-Bromoadenosine 3',5'-cyclic monophosphate is a stable cAMP analog that activates cAMP-dependent PKA. PKA can phosphorylate transcription factors, which may include ZNF285A, and thus stimulate its transcriptional activity. | ||||||