ZNF257 Activators
ZNF257 can initiate a cascade of intracellular events leading to its functional activation. Phorbol 12-myristate 13-acetate (PMA) is one such activator, targeting protein kinase C (PKC) that phosphorylates a variety of substrates, including ZNF257. This phosphorylation by PKC is a crucial step that can activate ZNF257, enabling it to carry out its role in cellular processes. Forskolin operates through a different mechanism, raising intracellular cAMP levels that activate protein kinase A (PKA), another kinase that can phosphorylate ZNF257. Similarly, dibutyryl-cAMP, a membrane-permeable analog of cAMP, also activates PKA, which can then act on ZNF257. Both Forskolin and dibutyryl-cAMP ensure that ZNF257 is primed for action via the PKA route.
Ionomycin, by increasing intracellular calcium, can activate calmodulin-dependent kinase (CaMK) which is capable of phosphorylating ZNF257. Epidermal Growth Factor (EGF) and Insulin, through their respective receptors, initiate the MAPK/ERK and PI3K/Akt pathways that can lead to the phosphorylation of ZNF257. Isoproterenol's engagement with beta-adrenergic receptors also raises cAMP levels, thereby activating PKA that can target ZNF257. Retinoic Acid, by binding to its specific nuclear receptors, can influence the transcriptional landscape within which ZNF257 operates. In contrast, Lithium Chloride indirectly inhibits GSK-3β, modulating pathways like Wnt, which can have downstream effects on ZNF257 activity. Further, 6-Benzylaminopurine, through activation of cyclin-dependent kinases (CDKs), and Curcumin, by activating the AMPK pathway, can both lead to modifications of ZNF257. Sphingosine-1-phosphate, binding to its receptors, can activate signaling pathways such as PI3K/Akt or MAPK/ERK, which are known to phosphorylate and activate proteins like ZNF257. Through these diverse mechanisms, these chemical activators ensure that ZNF257 is phosphorylated and activated, thereby fulfilling its cellular functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which is known to phosphorylate a variety of protein substrates including ZNF257. PKC-mediated phosphorylation can lead to the functional activation of ZNF257. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels, which in turn activates PKA. PKA phosphorylates a broad range of targets including transcription factors like ZNF257, potentially leading to its functional activation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin increases intracellular calcium concentration, which can activate calmodulin-dependent kinase (CaMK). CaMK can phosphorylate transcription factors and might directly phosphorylate ZNF257 leading to its activation. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin receptor activation stimulates the PI3K/Akt pathway. Akt kinase can phosphorylate and regulate the activity of numerous proteins, potentially including ZNF257, resulting in its functional activation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid binds to retinoic acid receptors which can heterodimerize with other nuclear receptors and transcription factors, potentially influencing the functional activity of ZNF257 through altered transcriptional regulation. | ||||||
6-Benzylaminopurine | 1214-39-7 | sc-202428 sc-202428A | 1 g 5 g | $20.00 $51.00 | ||
As a synthetic cytokinin, 6-Benzylaminopurine is known to activate cyclin-dependent kinases (CDKs). CDKs can phosphorylate a diverse set of proteins and could contribute to the functional activation of the transcription factor ZNF257. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol activates beta-adrenergic receptors leading to the activation of adenylate cyclase and an increase in cAMP, which activates PKA. PKA can then phosphorylate and activate transcription factors such as ZNF257. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium inhibits GSK-3β indirectly leading to the activation of Wnt signaling pathway. The activation of Wnt pathway can lead to the modulation of gene expression and potentially the functional activation of ZNF257. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a membrane-permeable cAMP analog that activates PKA. Activation of PKA can result in the phosphorylation and activation of transcription factors, including ZNF257. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can activate the AMPK pathway which in turn can phosphorylate transcription factors and other regulatory proteins, potentially leading to the functional activation of ZNF257. | ||||||