ZNF257 Inhibitors
Chemical inhibitors of ZNF257 can interfere with the protein's activity through various molecular mechanisms that involve the inhibition of specific signaling pathways and kinase activities. Staurosporine, a well-known kinase inhibitor, can prevent the phosphorylation of proteins downstream of ZNF257, thereby inhibiting its functional engagement with other cellular components. Similarly, Bisindolylmaleimide I targets protein kinase C (PKC), leading to the inhibition of PKC-dependent pathways that regulate proteins associated with ZNF257's function. LY294002, a PI3K inhibitor, interrupts the PI3K/AKT signaling cascade, which is often implicated in regulating protein activity, including that of ZNF257. The MEK inhibitor PD98059 disrupts the MAPK/ERK pathway, which is a potential route for ZNF257 regulation, while SB203580 specifically blocks p38 MAP kinase, which could play a role in regulating ZNF257 activity.
U0126 further inhibits MEK1/2, targeting the same MAPK/ERK pathway that could be essential for the regulation of ZNF257. The JNK pathway, another critical signaling mechanism, can be inhibited by SP600125, thus potentially altering ZNF257's activity. Src family kinases, which are inhibited by PP2, are important mediators of various signaling pathways, and their inhibition can affect ZNF257 regulation. Y-27632 disrupts the Rho/ROCK pathway, impacting cytoskeletal organization and potentially influencing ZNF257 function due to changes in cellular architecture. PD173074 and SU5402, both FGFR inhibitors, block the signaling that may be crucial for the activity of proteins interacting with or regulating ZNF257. Lastly, Chelerythrine, another PKC inhibitor, inhibits signaling pathways that contribute to the functional regulation of ZNF257, further demonstrating the diverse yet specific chemical strategies to inhibit this protein's activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases, which can inhibit ZNF257 by inhibiting kinases that are necessary for the phosphorylation events that activate downstream proteins required for ZNF257's function. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is a specific inhibitor of protein kinase C (PKC), which can inhibit ZNF257 by inhibiting PKC-dependent signaling pathways involved in the regulation of proteins that interact with or regulate ZNF257. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a specific inhibitor of phosphoinositide 3-kinases (PI3K), which can inhibit ZNF257 by blocking the PI3K/AKT signaling pathway that may be involved in the functional regulation of ZNF257 or its interacting partners. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of mitogen-activated protein kinase kinase (MEK), which can inhibit ZNF257 by blocking the MAPK/ERK pathway that could be involved in the functional activity of ZNF257. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAP kinase, which can inhibit ZNF257 by disrupting the p38 MAPK signaling pathway, potentially involved in the regulation of ZNF257's activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, which can inhibit ZNF257 by inhibiting the MAPK/ERK pathway that may be required for the regulation of ZNF257 activity or its interacting proteins. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which can inhibit ZNF257 by inhibiting the JNK signaling pathway that may play a role in the functional regulation of ZNF257. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is a selective inhibitor of Src family tyrosine kinases, which can inhibit ZNF257 by inhibiting Src kinase-mediated signaling pathways that may be involved in the regulation of ZNF257. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is an inhibitor of the Rho-associated protein kinase (ROCK), which can inhibit ZNF257 by disrupting the Rho/ROCK pathway that can be involved in cytoskeletal organization, potentially affecting the function of ZNF257. | ||||||
PD173074 | 219580-11-7 | sc-202610 sc-202610A sc-202610B | 1 mg 5 mg 50 mg | $46.00 $140.00 $680.00 | 16 | |
PD173074 is a selective inhibitor of fibroblast growth factor receptors (FGFR), which can inhibit ZNF257 by blocking the FGFR signaling pathway that may be required for the regulation of proteins interacting with or regulating ZNF257. | ||||||