ZNF191 Activators
ZNF191 Activators comprise a range of chemical compounds that directly or indirectly enhance the functional activity of ZNF191 by modulating various intracellular signaling pathways and molecular interactions. Forskolin elevates intracellular cAMP, leading to the activation of PKA, which could enhance ZNF191's transcriptional activity by phosphorylating proteins that interact with the DNA-binding domains of ZNF191 or facilitate its nuclear localization. Phorbol 12-myristate 13-acetate (PMA) serves as an activator of protein kinase C (PKC), which may similarly phosphorylate and thus potentiate ZNF191's interaction with its target gene promoters. Ionomycin and A23187, by increasing intracellular calcium concentrations, can activate calcium-dependent proteins that interact with or modify ZNF191, thereby enhancing its DNA-binding efficiency and transcriptional regulation. Additionally, the cAMP analog 8-Bromo-cAMP reinforces these pathways through PKA activation, potentially amplifying ZNF191's regulatory effects on gene expression.
Furthermore, compounds like Spermine, Trichostatin A, and 5-Azacytidine alter the DNA structure and chromatin state, which can improve ZNF191's access to its DNA binding sites, thus enhancing its transcriptional control. Trichostatin A, by promoting histone hyperacetylation, and 5-Azacytidine, by reducing DNA methylation, facilitate a more open chromatin conformation favorable for ZNF191 binding. Bay K8644 augments calcium influx through L-type calcium channels, further supporting calcium-dependent modulation of ZNF191 activity. Retinoic acid and Vitamin D3, through their influence on cell differentiation and gene expression, may enhance ZNF191's regulatory roles potentially by altering the expression of genes that interact with ZNF191. Lastly, Zinc sulfate provides a structural cofactor for ZNF191, crucial for its DNA-binding capability, thus directly enhancing its transcriptional regulatory function. Collectively, these ZNF191 activators orchestrate a symphony of biochemical events that upregulate the functional activity of ZNF191 without necessitating changes in its expression levels.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a diterpene that activates adenylyl cyclase, resulting in increased levels of cyclic AMP (cAMP) within cells. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate various proteins, potentially enhancing the DNA-binding activity of ZNF191 as it may rely on phosphorylation states for its functional conformation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA acts as a diacylglycerol (DAG) analog which activates protein kinase C (PKC). PKC phosphorylation can alter the transcriptional activity of various zinc finger proteins, potentially increasing the functional activity of ZNF191 by promoting its interaction with DNA or other regulatory proteins. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, activating calcium-dependent signaling pathways. The rise in intracellular calcium may enhance the activity of ZNF191 by facilitating its binding to DNA or interaction with other regulatory proteins that are sensitive to calcium signaling. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog which activates cAMP-dependent pathways such as PKA. Activation of PKA may promote the phosphorylation of proteins that interact with ZNF191, enhancing its transcriptional regulation capabilities. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $61.00 $196.00 $277.00 $901.00 | 1 | |
Spermine is a polyamine that is known to stabilize DNA duplexes and enhance the binding of certain DNA-binding proteins. It could enhance the binding efficiency of ZNF191 to DNA, thus increasing its transcriptional regulatory activities. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
TSA is a histone deacetylase inhibitor that causes hyperacetylation of histones, leading to a more relaxed chromatin structure. This may enhance the access of ZNF191 to its target DNA sequences, potentially increasing its transcriptional activity. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor, reducing DNA methylation and thereby often resulting in gene activation. This could enhance the activity of ZNF191 by increasing its access to previously methylated DNA regions. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is another calcium ionophore increasing intracellular calcium, similar to Ionomycin. It may enhance the activity of ZNF191 by influencing calcium-dependent proteins that interact or cooperate with ZNF191 in the nucleus. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $84.00 $196.00 $817.00 | ||
Bay K8644 is an L-type calcium channel agonist that increases calcium influx, potentially enhancing calcium-dependent mechanisms that could upregulate the functional activity of ZNF191 by post-translational modifications or interactions. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid influences cell differentiation and can modulate gene expression. It may enhance the activity of ZNF191 by affecting the transcriptional regulation of genes that either cooperate with or are regulated by ZNF191. | ||||||