ZNF167 Activators
ZNF167 activators comprise a diverse array of chemical compounds that indirectly augment the functional activity of ZNF167, a transcription factor encoded by the gene ZKSCAN7. Compounds like Isoprenaline, Forskolin, and IBMX work through the elevation of intracellular cAMP levels, subsequently activating protein kinase A (PKA), which is known to phosphorylate a broad range of substrates, including transcription factors. This cascade might enhance ZNF167's regulatory influence on gene expression by facilitating its DNA binding or interaction with other transcriptional co-regulators. Phorbol 12-myristate 13-acetate (PMA) activates PKC, which can also modify the activity of proteins that associate with ZNF167; these modifications could potentiate ZNF167's gene regulatory functions. Similarly, calcium ionophores like Ionomycin and A23187 can trigger signaling pathways involving calcium/calmodulin-dependent protein kinases that might affect the transcriptional machinery ZNF167 interacts with, leading to enhanced gene regulation.
Epigallocatechin gallate (EGCG) and the DNA methylation inhibitors 5-Aza-2'-deoxycytidine and Sodium Butyrate, along with Trichostatin A, an HDAC inhibitor, can induce epigenetic changes that may improve ZNF167's access to DNA binding sites or affect the expression of its coregulatory proteins, thereby amplifying its role in transcriptional regulation. Retinoic acid, by acting on nuclear receptors, can also induce gene expression modifications that could synergize with ZNF167's function. Lastly, Lithium Chloride's inhibition of GSK-3β may lead to alterations in gene expression patterns that support the transcriptional activities of ZNF167, suggesting a complex network of intracellular pathways through which these activators can enhance the functional role of ZNF167 in gene regulation. Collectively, these molecules contribute to the intricate regulation of gene expression by modulating the activity of ZNF167 through various biochemical mechanisms without altering its expression levels directly.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
A beta-adrenergic agonist that stimulates adenylyl cyclase, leading to increased cAMP levels within cells. Elevated cAMP activates PKA, which can phosphorylate various transcription factors, potentially enhancing ZNF167's DNA binding activity and influence on gene expression due to ZNF167's role as a transcription factor. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Directly activates adenylyl cyclase, increasing intracellular cAMP and activation of PKA. PKA may phosphorylate transcription regulatory proteins, thus potentially enhancing the transcription regulatory function of ZNF167 by promoting its binding to DNA or co-factors involved in gene regulation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
A non-selective inhibitor of phosphodiesterases, which prevents cAMP degradation, leading to increased PKA activity. This could enhance ZNF167's role in transcription regulation by influencing the phosphorylation state of proteins within the transcription machinery that ZNF167 interacts with. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
An activator of protein kinase C (PKC) that could influence transcription factors and co-factors interacting with ZNF167, potentially enhancing ZNF167's function in gene expression regulation by altering the phosphorylation state and activity of these transcriptional regulators. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $94.00 $259.00 | 2 | |
A calcium ionophore which increases intracellular calcium concentration, potentially affecting calcium/calmodulin-dependent protein kinases (CaMK) and thereby influencing transcription factors and cofactors that interact with ZNF167, possibly enhancing ZNF167's transcriptional regulatory activities. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Another calcium ionophore, which, similar to ionomycin, increases intracellular calcium levels, possibly impacting transcription factors and cofactors that ZNF167 interacts with, potentially enhancing the transcriptional regulatory activity of ZNF167 through calcium signaling pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
A polyphenol found in green tea that has been shown to inhibit DNA methyltransferases (DNMTs). By altering the methylation status of genes, EGCG could influence the expression and activity of transcription factors and thus enhance ZNF167's ability to regulate gene transcription. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
A histone deacetylase (HDAC) inhibitor that leads to a more relaxed chromatin structure and increased access for transcription factors. This could enhance ZNF167's role in gene regulation by increasing its access to DNA binding sites. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
An inhibitor of DNA methyltransferases, leading to demethylation and potentially increased expression of genes. This could enhance ZNF167 activity by altering the expression of cofactors or target genes that are regulated by ZNF167, thus influencing its role in transcription regulation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Similar to sodium butyrate, as an HDAC inhibitor, it could enhance the transcriptional regulatory function of ZNF167 by improving access to chromatin and thereby allowing better binding to DNA and cofactors involved in gene regulation. | ||||||