ZNF140 Activators
Chemical activators of ZNF140 can modulate its activity through various intracellular signaling pathways that lead to its phosphorylation. Forskolin, by elevating intracellular cyclic AMP (cAMP) levels, indirectly facilitates the activation of protein kinase A (PKA). This kinase can then target serine and threonine residues on ZNF140 for phosphorylation, effectively leading to its functional activation. Ionomycin raises intracellular calcium levels, which can activate calmodulin-dependent kinases (CaMK). These kinases have the capability to phosphorylate ZNF140, thereby modulating its activity. In a similar vein, Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which also phosphorylates serine or threonine residues on ZNF140, tailoring its activation state.
Moreover, Okadaic Acid and Calyculin A both inhibit protein phosphatases 1 and 2A, tipping the cellular balance toward phosphorylation due to reduced dephosphorylation activity. This shift can lead to an increase in the phosphorylated form of ZNF140, culminating in its activation. Anisomycin activates stress-activated protein kinases (SAPKs), such as JNK, which may phosphorylate and activate ZNF140. Epidermal Growth Factor (EGF) and Insulin both initiate signaling cascades-MAPK/ERK and PI3K/Akt pathways, respectively-that include kinases capable of phosphorylating ZNF140. Retinoic Acid acts through nuclear receptors that may influence the phosphorylation state of ZNF140. Dibutyryl-cAMP, a cAMP analog, directly activates PKA, which then can phosphorylate ZNF140. Spermine, though its precise mechanism on ZNF140 is less direct, can influence the activity of kinases or phosphatases that modulate ZNF140 phosphorylation. Bryostatin activates PKC, potentially leading to ZNF140 phosphorylation and activation, highlighting the complex network of intracellular signals that converge on the modulation of ZNF140 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels. Increased calcium can activate calmodulin-dependent kinases (CaMK), which may phosphorylate ZNF140, resulting in its functional activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC). Once activated, PKC can phosphorylate ZNF140 on specific serine or threonine residues, thereby causing functional activation of the protein. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation levels within the cell due to reduced dephosphorylation. This can result in the phosphorylation-related activation of ZNF140, as the balance of kinase and phosphatase activities would be shifted towards phosphorylation. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Similar to Okadaic Acid, Calyculin A is an inhibitor of protein phosphatases, specifically PP1 and PP2A, which can enhance the phosphorylation state of ZNF140, resulting in its activation due to decreased dephosphorylation. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is known to activate stress-activated protein kinases (SAPKs), such as JNK. Activation of these kinases can lead to the phosphorylation and activation of transcription factors. As ZNF140 is a transcription factor, its activation could be mediated by phosphorylation through the SAPK pathway. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin activates the PI3K/Akt signaling pathway. Akt, a serine/threonine-specific protein kinase, can phosphorylate and activate various proteins, including transcription factors like ZNF140. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid acts through its nuclear receptors which can regulate gene expression by influencing the transcription machinery. Retinoic acid receptors interacting with co-activators could lead to the phosphorylation and functional activation of associated transcription factors such as ZNF140. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a membrane-permeable analog of cAMP that directly activates PKA. Activation of PKA can result in the phosphorylation and subsequent activation of ZNF140. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $61.00 $196.00 $277.00 $901.00 | 1 | |
Spermine can enhance the activity of certain kinases or inhibit phosphatases indirectly through cellular signaling mechanisms, which can lead to the phosphorylation and functional activation of proteins like ZNF140. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $245.00 | 9 | |
Bryostatin is a modulator of protein kinase C (PKC). It can activate PKC, leading to the phosphorylation and activation of downstream proteins. PKC-mediated phosphorylation of ZNF140 could lead to its functional activation. | ||||||