Zimp10 Activators
Zimp10 activators comprise a diverse collection of chemical compounds that facilitate the enhancement of Zimp10's role as a transcriptional coactivator. Compounds such as Forskolin, by increasing intracellular cAMP, and Phorbol 12-myristate 13-acetate (PMA), through PKC activation, lead to the phosphorylation of proteins that are crucial for Zimp10's functional activity. Ionomycin's ability to raise intracellular calcium levels indirectly augments Zimp10 activity by activating calcium-dependent proteins that interact with Zimp10. Lithium chloride, by inhibiting GSK-3, and 5-Azacytidine, through the inhibition of DNA methylation, create a favorable environment for Zimp10 to exert its coactivator influence on gene expression. Sphingosine-1-phosphate, through lipid signaling modulation, facilitates the recruitment and function of Zimp10 at gene promoters.
Moreover, signaling molecules like Retinoic acid and Pioglitazone, by binding to their respective nuclear receptors, enhance Zimp10's coactivation of transcription, illustrating the protein's involvement in ligand-dependent transcriptional regulation. Growth factors such as EGF trigger phosphorylation cascades that can promote Zimp10's coactivating functions. Furthermore, compounds like Curcumin andResveratrol, through their respective modulation of NF-κB and SIRT1 pathways, create a conducive regulatory environment that can indirectly enhance Zimp10's activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin raises intracellular cAMP levels, which in turn activates protein kinase A (PKA). PKA phosphorylates target proteins that can interact with Zimp10, leading to its functional enhancement, particularly in nuclear receptor coactivation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate proteins that associate with Zimp10. This phosphorylation can enhance Zimp10's coactivator functions in gene transcription. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, activating calmodulin-dependent kinase (CaMK), which can modify proteins interacting with Zimp10 and enhance its activity in gene regulation. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium inhibits glycogen synthase kinase-3 (GSK-3). GSK-3 regulates proteins that can bind to Zimp10, and its inhibition may potentiate Zimp10's transcriptional coactivator activity. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methylation inhibitor. By altering the methylation status of DNA, it can affect the binding of transcription factors that recruit Zimp10, thus enhancing its role in transcriptional regulation. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
This lipid signaling molecule can activate sphingosine kinase, which in turn may enhance Zimp10 activity by modulating its interactions with lipid raft-associated signaling complexes. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid is a ligand for retinoic acid receptors (RARs) which can form complexes with Zimp10, enhancing its ability to coactivate transcription in a ligand-dependent manner. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
As a PPARγ agonist, pioglitazone enhances the recruitment of coactivators like Zimp10 to PPARγ target genes, thereby increasing Zimp10's coactivation of transcription. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can modulate NF-κB signaling, which may influence the activity of Zimp10 as a coactivator in the regulation of NF-κB target genes. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates the SIRT1 deacetylase, which can deacetylate and affect proteins that interact with Zimp10, thus potentially enhancing its transcriptional coactivator activities. | ||||||