Zimp10 Antibody (G-12): sc-376825
- Zimp10 Antibody (G-12) is a mouse monoclonal IgG1 κ Zimp10 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 881-975 mapping near the C-terminus of Zimp10 of human origin
- Zimp10 Antibody (G-12) is recommended for detection of Zimp10 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including porcine
- Anti-Zimp10 Antibody (G-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Zimp10 Antibody (G-12) for WB applications. These reagents are now offered in bundles with Zimp10 Antibody (G-12) (see ordering information below).
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Zimp10 Antibody (G-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects Zimp10 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Zimp10 (G-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Zimp10 protein, also known as ZMIZ1 (zinc finger, MIZ-type containing 1), MIZ, or RAI17, is a 1,067 amino acid protein that plays a crucial role in cellular processes by localizing to both the nucleus and cytoplasm. A single SP-RING-type zinc finger in Zimp10 is essential for interaction with androgen receptor (AR). This interaction enhances AR′s ligand-dependent transcriptional activity and promotes sumoylation, a post-translational modification vital for AR stimulation and overall functionality. Zimp10 is predominantly expressed in ovary, prostate, testis, and spleen, and Zimp10 expression is regulated through alternative splicing, resulting in multiple isoforms. Zimp10 gene is located on human chromosome 10, a region harboring over 1,200 genes and implicated in various genetic disorders, including Charcot-Marie-Tooth disease and multiple endocrine neoplasia type 2. Zimp10′s ability to modulate AR activity underscores its importance in androgen signaling pathways, which are critical for reproductive health and development.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Zimp10 Antibody (G-12) References:
- Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. | Nagase, T., et al. 1999. DNA Res. 6: 337-45. PMID: 10574462
- hZimp10 is an androgen receptor co-activator and forms a complex with SUMO-1 at replication foci. | Sharma, M., et al. 2003. EMBO J. 22: 6101-14. PMID: 14609956
- The novel PIAS-like protein hZimp10 enhances Smad transcriptional activity. | Li, X., et al. 2006. J Biol Chem. 281: 23748-56. PMID: 16777850
- The novel PIAS-like protein hZimp10 is a transcriptional co-activator of the p53 tumor suppressor. | Lee, J., et al. 2007. Nucleic Acids Res. 35: 4523-34. PMID: 17584785
- The PIAS-like protein Zimp10 is essential for embryonic viability and proper vascular development. | Beliakoff, J., et al. 2008. Mol Cell Biol. 28: 282-92. PMID: 17967885
- Fusion of ZMIZ1 to ABL1 in a B-cell acute lymphoblastic leukaemia with a t(9;10)(q34;q22.3) translocation. | Soler, G., et al. 2008. Leukemia. 22: 1278-80. PMID: 18007576
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Zimp10 Antibody (G-12) | sc-376825 | 200 µg/ml | $322.00 | |||
Zimp10 Antibody (G-12): m-IgG Fc BP-HRP Bundle | sc-529943 | 200 µg Ab; 10 µg BP | $361.00 | |||
Zimp10 Antibody (G-12): m-IgGκ BP-HRP Bundle | sc-523108 | 200 µg Ab, 40 µg BP | $361.00 | |||
Zimp10 Antibody (G-12): m-IgG1 BP-HRP Bundle | sc-543777 | 200 µg Ab; 20 µg BP | $361.00 | |||
Zimp10 Antibody (G-12) AC | sc-376825 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Zimp10 Antibody (G-12) HRP | sc-376825 HRP | 200 µg/ml | $322.00 | |||
Zimp10 Antibody (G-12) FITC | sc-376825 FITC | 200 µg/ml | $336.00 | |||
Zimp10 Antibody (G-12) PE | sc-376825 PE | 200 µg/ml | $349.00 | |||
Zimp10 Antibody (G-12) Alexa Fluor® 488 | sc-376825 AF488 | 200 µg/ml | $364.00 | |||
Zimp10 Antibody (G-12) Alexa Fluor® 546 | sc-376825 AF546 | 200 µg/ml | $364.00 | |||
Zimp10 Antibody (G-12) Alexa Fluor® 594 | sc-376825 AF594 | 200 µg/ml | $364.00 | |||
Zimp10 Antibody (G-12) Alexa Fluor® 647 | sc-376825 AF647 | 200 µg/ml | $364.00 | |||
Zimp10 Antibody (G-12) Alexa Fluor® 680 | sc-376825 AF680 | 200 µg/ml | $364.00 | |||
Zimp10 Antibody (G-12) Alexa Fluor® 790 | sc-376825 AF790 | 200 µg/ml | $364.00 |