Zic2 Activators
Zic2, a member of the zinc finger transcription factor family, plays a crucial role in embryonic development, particularly in the formation of the neural tube and the development of the central nervous system. Zinc finger proteins are known for their ability to bind to specific DNA sequences and regulate the expression of target genes. Zic2, specifically, is involved in processes such as cell proliferation, differentiation, and migration during embryogenesis. Researchers often explore ways to modulate the activity of transcription factors like Zic2 to better understand the intricate regulatory networks governing developmental processes.
Activators, in a chemical context, refer to molecules or compounds that enhance the activity of a particular biological process or protein. These substances can function by promoting the binding of transcription factors to their target DNA sequences, thereby increasing gene expression. The identification and study of activators for specific transcription factors like Zic2 contribute to our understanding of the molecular mechanisms underlying developmental pathways. Researchers may investigate natural or synthetic compounds that can influence Zic2 activity, shedding light on the intricate control mechanisms governing embryonic development and potentially providing insights into related physiological processes.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to increased cAMP levels. cAMP is known to activate protein kinase A (PKA), which can phosphorylate and activate various proteins, potentially including Zic2 | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a nonspecific inhibitor of phosphodiesterases, which are enzymes that break down cAMP. By preventing the breakdown of cAMP, IBMX can indirectly maintain the activation of proteins such as Zic2 | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of Protein Kinase C (PKC), which can phosphorylate and activate a variety of proteins. It is conceivable that Zic2 could be among these proteins | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog. It activates PKA, potentially affecting proteins like Zic2 | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram inhibits phosphodiesterase-4, preventing the breakdown of cAMP and thereby maintaining the activation of proteins potentially including Zic2 | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A. By inhibiting these enzymes, it prevents the dephosphorylation and deactivation of proteins, potentially including Zic2 | ||||||
Ro 20-1724 | 29925-17-5 | sc-200709 sc-200709A sc-200709B | 100 mg 1 g 5 g | $87.00 $426.00 $1574.00 | 17 | |
Ro 20-1724 inhibits PDE4, thereby preventing the breakdown of cAMP and maintaining the activation of proteins potentially including Zic2 | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $94.00 $186.00 | 71 | |
H89 is an inhibitor of PKA, thus it could potentially indirectly affect proteins that are downstream in the signaling pathway, potentially including Zic2 | ||||||
KT 5720 | 108068-98-0 | sc-3538 sc-3538A sc-3538B | 50 µg 100 µg 500 µg | $138.00 $220.00 $972.00 | 47 | |
KT 5720 is a potent and selective inhibitor of PKA, which could potentially influence the activity of proteins downstream in the signaling pathway, potentially including Zic2 | ||||||
KN-62 | 127191-97-3 | sc-3560 | 1 mg | $136.00 | 20 | |
KN-62 is an inhibitor of Ca2+/calmodulin-dependent protein kinase II, thus it could potentially indirectly affect proteins that are downstream in the signaling pathway, potentially including Zic2 | ||||||