ZFYVE28 Activators
ZCWPW1 Activators are a series of chemical compounds that modulate cellular signaling and chromatin states, indirectly promoting the functional activity of ZCWPW1. Compounds such as Forskolin and 8-Bromoadenosine 3',5'-cyclic monophosphate (8-Br-cAMP) boost intracellular cAMP levels, which activate PKA. This kinase, in turn, may phosphorylate substrates that facilitate ZCWPW1's role in the recognition and interaction with modified histones, thus enhancing its chromatin remodeling capabilities. Similarly, Ionomycin, by increasing intracellular calcium concentrations, may promote ZCWPW1's interaction with calcium-dependent proteins involved in chromatin modification. Additionally, histone deacetylase inhibitors like Trichostatin A (TSA), SAHA, Nicotinamide, and MS-275, by maintaining acetylated histone states, can create an environment conducive toZCWPW1's binding to histones, potentially augmenting its regulatory influence on gene expression. These inhibitors also contribute to a more open chromatin conformation, which aligns with ZCWPW1's functionalities in epigenetic modulation.
The activity of ZCWPW1 is further facilitated by chemicals that modify the methylation landscape of chromatin. DNA methylation inhibitors such as 5-Azacytidine and RG108 lead to reduced DNA methylation, which could enhance ZCWPW1's chromatin association, thereby indirectly amplifying its role in gene regulation. Aurora kinase inhibition by compounds like ZM 447439 may enhance ZCWPW1's interaction with chromatin due to reduced histone phosphorylation, while EPZ-6438's inhibition of EZH2 could increase the presence of histone methylation marks that are recognized by ZCWPW1. Furthermore, (-)-Epigallocatechin gallate (EGCG) is known to influence histone acetylation pathways, potentially supporting the chromatin-related functions of ZCWPW1. Collectively, these activators contribute to a chromatin landscape that is favorable for ZCWPW1's involvement in gene expression regulation by enhancing the recognition and binding of specific histone modifications.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, increasing intracellular cAMP levels. Elevated cAMP activates PKA, which can phosphorylate various proteins, potentially enhancing the activity of ZCWPW1 by promoting its interaction with chromatin remodeling complexes. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
8-Br-cAMP is a cell-permeable cAMP analog that activates PKA. PKA activation can lead to the phosphorylation of proteins involved in chromatin modification, indirectly increasing ZCWPW1's ability to act in histone modification processes. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, potentially facilitating the interaction of ZCWPW1 with calcium-binding proteins involved in chromatin remodeling. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
TSA is an inhibitor of histone deacetylases (HDACs). By preventing deacetylation, it may create a permissive chromatin state that indirectly enhances ZCWPW1's role in histone modification through its interaction with methylated histones. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine inhibits DNA methyltransferases, leading to DNA demethylation. This can create a chromatin context that facilitates ZCWPW1's binding to histones, indirectly enhancing its role in epigenetic regulation. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
ZM 447439 is an Aurora kinase inhibitor, which may stabilize chromatin structure and enhance ZCWPW1's interaction with chromatin due to decreased phosphorylation of histone H3, a substrate of Aurora kinases. | ||||||
EPZ6438 | 1403254-99-8 | sc-507456 | 1 mg | $66.00 | ||
EPZ-6438 is an inhibitor of the histone methyltransferase EZH2. Inhibiting EZH2 may increase histone methylation marks recognized by ZCWPW1, potentially enhancing its chromatin association and function in gene regulation. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Nicotinamide is an inhibitor of the sirtuin family of deacetylases. By inhibiting sirtuins, it may indirectly enhance ZCWPW1's function by maintaining acetylated states of histones that ZCWPW1 can bind to. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
SAHA is a broad-spectrum HDAC inhibitor that could promote a more open chromatin state, potentially enhancing ZCWPW1's role in the recognition of specific histone marks and the regulation of gene expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG can modulate various signaling pathways, including those associated with histone acetylation. By influencing these pathways, EGCG may indirectly enhance ZCWPW1's activity in chromatin remodeling and gene regulation. | ||||||