ZFYVE28 Inhibitors
ZFYVE28 inhibitors belong to a class of chemical compounds that specifically target the zinc finger FYVE domain-containing protein 28 (ZFYVE28). The FYVE domain is a conserved motif found in various proteins involved in membrane trafficking and signaling processes within cells. ZFYVE28, also known as endofin, is one such protein that contains the FYVE domain, playing a crucial role in intracellular membrane dynamics. The inhibition of ZFYVE28 by these specialized compounds disrupts its normal cellular functions, leading to alterations in membrane-related processes.
The primary mechanism of action of ZFYVE28 inhibitors involves interference with the protein's ability to interact with membranes. ZFYVE28 is known to bind to phosphatidylinositol 3-phosphate (PI3P), a phospholipid present in cellular membranes. This interaction is vital for the proper localization and functioning of ZFYVE28 in membrane-associated events. By inhibiting this interaction, ZFYVE28 inhibitors disrupt the normal membrane-related functions mediated by ZFYVE28. This interference may have implications for various cellular processes, including endosomal trafficking, autophagy, and signaling cascades. As research in this field advances, a deeper understanding of the specific effects and potential applications of ZFYVE28 inhibitors in various cellular contexts is likely to emerge.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A potent phosphatidylinositol 3-kinase (PI3K) inhibitor. ZFYVE28 is believed to interact with PI3K products. Inhibition of PI3K activity by Wortmannin could prevent the recruitment of ZFYVE28 to the membrane, thus inhibiting its function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A selective inhibitor of PI3Ks. Similar to Wortmannin, LY294002 would likely interfere with ZFYVE28's association with PI3K signaling products, which is essential for its activity. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $56.00 $256.00 | 113 | |
Inhibitor of autophagy through inhibition of class III PI3K. It can indirectly affect ZFYVE28 function by disrupting the autophagic processes that ZFYVE28 may be involved in. | ||||||
Spautin-1 | 1262888-28-7 | sc-507306 | 10 mg | $165.00 | ||
A specific inhibitor of autophagy that promotes the degradation of class III PI3K Vps34 complex components. This may indirectly reduce ZFYVE28 function by impairing the autophagic machinery it may interact with. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
A selective inhibitor of MEK1/2, which are upstream of the ERK pathway. ZFYVE28, if linked to ERK signaling, could have its activity modulated indirectly by U0126 through this pathway. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
An inhibitor of MEK activation, thereby preventing the activation of MAPK/ERK. This could indirectly influence ZFYVE28 if it is involved in ERK signaling. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
A specific inhibitor of the vacuolar type H+-ATPase (V-ATPase). By inhibiting V-ATPase, Bafilomycin A1 can disrupt endosomal acidification, potentially affecting ZFYVE28's endosomal localization and function. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
A non-competitive inhibitor of dynamin, affecting endocytosis. ZFYVE28, being associated with membrane trafficking, could be indirectly inhibited if endocytosis is disrupted. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $134.00 $502.00 | 7 | |
A selective inhibitor of Cdc42 GTPase. If ZFYVE28 is involved in signaling pathways regulated by Cdc42, its function could be indirectly inhibited by ML141. | ||||||
SecinH3 | 853625-60-2 | sc-203260 | 5 mg | $273.00 | 6 | |
An inhibitor of cytohesin, affecting ARF6 activation. As ZFYVE28 may be part of pathways involving ARF6, SecinH3 could indirectly reduce its functional activity. | ||||||