Molecular structure of SecinH3, CAS Number: 853625-60-2
SecinH3 (CAS 853625-60-2)
See product citations (6)
Application:
SecinH3 is a cell-permeable triazolo compound that acts as a Sec7 domain-binding selective antagonist
CAS Number:
853625-60-2
Purity:
≥98%
Molecular Weight:
460.5
Molecular Formula:
C24H20N4O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
SecinH3 is a cell-permeable triazolo compound that acts as a Sec7 domain-binding (Kd ≤250 nM for Sec7 from human cytohesins 1-3), selective antagonist against cytohesin family small nucleotide exchange factors, or GEFs (IC50 ≤5.6 muM in ARF1 GDP/GTP exchange assays using human cytohesin 3, as well as murine and Drosophila homologues). SecinH3 inhibits large GEFs only at much higher concentrations (IC50 ≥65 muM in GDP/GTP exchange assays using hEFA6-S7 and yGea2-S7) and exhibits little activity against a panel of 10 studied kinases or hSosII. SecinH3 was shown to effectively inhibit insulin signaling both in HepG2 cells in vitro and in Drosophila and mice in vivo. SecinH3 is an inhibitor of cytohesin-1, cytohesin-2 and GRP1.
SecinH3 (CAS 853625-60-2) References
- Inhibition of cytohesins by SecinH3 leads to hepatic insulin resistance. | Hafner, M., et al. 2006. Nature. 444: 941-4. PMID: 17167487
- The cytohesin Steppke is essential for insulin signalling in Drosophila. | Fuss, B., et al. 2006. Nature. 444: 945-8. PMID: 17167488
- Affinity-based labeling of cytohesins with a bifunctional SecinH3 photoaffinity probe. | Bi, X., et al. 2008. Angew Chem Int Ed Engl. 47: 9565-8. PMID: 18972479
- Cytohesin-1 regulates the Arf6-phospholipase D signaling axis in human neutrophils: impact on superoxide anion production and secretion. | El Azreq, MA., et al. 2010. J Immunol. 184: 637-49. PMID: 20018626
- A trifluoromethylphenyl diazirine-based SecinH3 photoaffinity probe. | Albertoni, B., et al. 2012. Chem Commun (Camb). 48: 1272-4. PMID: 22179571
- Anti-proliferative effect of cytohesin inhibition in gefitinib-resistant lung cancer cells. | Bill, A., et al. 2012. PLoS One. 7: e41179. PMID: 22815959
- Design and Synthesis of New (SecinH3) Derivatives as Potential Cytohesin Inhibitors. | Hayallah, AM. 2014. Indian J Pharm Sci. 76: 387-400. PMID: 25425752
- The cytohesin guanosine exchange factors (GEFs) are required to promote HGF-mediated renal recovery after acute kidney injury (AKI) in mice. | Reviriego-Mendoza, MM. and Santy, LC. 2015. Physiol Rep. 3: PMID: 26116550
- Effect of SecinH3 on lung injury induced by sepsis of rats. | Guo, F. and Yan, CY. 2015. Asian Pac J Trop Med. 8: 1049-1054. PMID: 26706678
- Inhibition of smooth muscle contraction and ARF6 activity by the inhibitor for cytohesin GEFs, secinH3, in the human prostate. | Herlemann, A., et al. 2018. Am J Physiol Renal Physiol. 314: F47-F57. PMID: 28855187
- SecinH3 Attenuates TDP-43 p.Q331K-Induced Neuronal Toxicity by Suppressing Endoplasmic Reticulum Stress and Enhancing Autophagic Flux. | Hu, W., et al. 2019. IUBMB Life. 71: 192-199. PMID: 30376609
- CLIC4/Arf6 Pathway. | Abdul-Salam, VB., et al. 2019. Circ Res. 124: 52-65. PMID: 30582444
- Genome-wide CRISPR-Cas9 screening identifies the CYTH2 host gene as a potential therapeutic target of influenza viral infection. | Yi, C., et al. 2022. Cell Rep. 38: 110559. PMID: 35354039
- Physiological and Pathological Roles of the Cytohesin Family in Neurons. | Ito, A., et al. 2022. Int J Mol Sci. 23: PMID: 35563476
- Blocking the cytohesin-2/ARF1 axis by SecinH3 ameliorates osteoclast-induced bone loss via attenuating JNK-mediated IRE1 endoribonuclease activity. | Dong, Y., et al. 2022. Pharmacol Res. 185: 106513. PMID: 36252772
Inhibitor of:
β′-COP, γ-SNAP, ACAP1, ACAP2, ADP-ribosylation factor (ARF), AGAP1, ANKRD13C, AP-3σ2, ARAP1, ARF1, Arf2, ARF7, ARFGAP, ARFGAP2, ARFGAP3, ARFGEF (BIG1, BIG2, BIG3), ARFRP1, ARHGAP11B, ARHGAP15, ARHGAP21, ARHGAP36, ARHGAP39, ARHGAP40, ARHGEF10, ARHGEF19, ARHGEF39, ARHGEF5_Arhgef5, ARHGEF5L, ARHGEF9, ARL14EPL, ARL16, ARL4, ARL4D, ARL5A, ARL5B, ARL7, ARL9, ARNO, Atlastin, BET5, BRAG2, C11orf2, CAPS1, Cdc42, CdGAP, Centaurin α1, Centaurin γ3, COPI (Coat Protein Complex I), COPZ, COPZ2, cytohesin-1, cytohesin-2, DENND2C, DENND4C, DENND5B, DENND6B, DIRAS2, Drac1/2, E130112L23Rik, E430025E21Rik, EG432555, EG433102, Elmo1, ENTHD1, EPI64, EVT-2, FAM109A, FAM18A, FGD6, Gα i-1, Gγ 10, GAIP, GBF1, GBP8, Gbp9, GIMAP3, GIMAP9, girdin, Gm1527, Gm949, GOLGA8A, GOLGA8G, GOLGA8J, GOLGA8R, GOLGB1, Golgin 45, GOLPH4, Gpa2, GPB5, GPR101, GRP1, Intersectin, IntersectinL, IPCEF1, IQSEC2, LIN-10, LLGL4, Ly-GDI, MCF2L2, MIA2, Moesin, MON1A, MrgB13, OR1A2, ORF19, OTTMUSG00000005723, PACS-1b, PC-PLD2B, PITP, PITPNC1, PLEKHG1, PLEKHG2, PLEKHG6, POR1, Rab 16, Rab 1B, Rab 23, Rab 27b, Rab 2A, Rab 2B, Rab 30, Rab 32, Rab 33A, Rab 35, Rab 38, Rab 39A, Rab 3A, Rab 3C, Rab 3D, Rab 43, Rab 4B, Rab 7L1, Rab 8A, Rab 9A, Rab 9B, Rab GDI (GDP dissociation inhibitor), Rab GTPase (RAB; RAS oncogene), Rab11-FIP1, Rab11-FIP2, Rab11-FIP3, Rab11-FIP4, RAB3IL1, Rab40B, RABAPTIN-5, Rabaptin-5β, Ral GPS1, RAPGEF5, RASA4B, RB3, Regulator of G protein signaling (RGS), Repac, RGL3, RGS21, Rho 8, Rho GDI, RIC-8A, RILPL2, RIN3, RINL, RINT-1, RSC1A1, Sar1, Sar1a, Sec15B, SEC23A, SEC23B, SEC24A, Sec24C, Sec31, Sec61α2, Sec61β, SH3BP4, Slac2-c, SMAP1, SYDE1, Syntaxin 1, Syntaxin 11, Syntaxin 5, TBC1D13, TBC1D19, TBC1D2, TBC1D22B, TBC1D23, TBC1D25, TBC1D2B, TBC1D3, TBC1D30, TC10, TGN38B, TGTP2, TIP20, TMED8, TMED9, Tomosyn, TRAPPC5, Unc18-2, v-SNARE Vti1a, VAMP-1, VAMP-4, VEPH1, VIPAR, VPS51, WDR26, YIF1A, YIPF3, YJEFN3, ZFYVE27, and ZFYVE28.Activator of:
ARHGAP6, Cdc42EP5, cytohesin-1, D030016E14Rik, D030074E01Rik, epsin 2, ERGIC-2, FLJ13611, GCC2, Gm949, RAb 19B, Rab 1A, Rabex-5, RIP/Rab, Unc18-2, and VPS26B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SecinH3, 5 mg | sc-203260 | 5 mg | $273.00 |