Molecular structure of Spautin-1, CAS Number: 1262888-28-7
Spautin-1 (CAS 1262888-28-7)
Alternate Names:
6-fluoro-N-[(4-fluorophenyl)methyl]-4-quinazolinamine
CAS Number:
1262888-28-7
Molecular Weight:
271.26
Molecular Formula:
C15H11F2N3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Spautin-1 (CAS 1262888-28-7) References
- Spautin-1, a novel autophagy inhibitor, enhances imatinib-induced apoptosis in chronic myeloid leukemia. | Shao, S., et al. 2014. Int J Oncol. 44: 1661-8. PMID: 24585095
- The autophagy inhibitor spautin-1, either alone or combined with doxorubicin, decreases cell survival and colony formation in canine appendicular osteosarcoma cells. | Schott, CR., et al. 2018. PLoS One. 13: e0206427. PMID: 30372478
- Potent USP10/13 antagonist spautin-1 suppresses melanoma growth via ROS-mediated DNA damage and exhibits synergy with cisplatin. | Guo, J., et al. 2020. J Cell Mol Med. 24: 4324-4340. PMID: 32129945
- Structure-Activity Relationship (SAR) Study of Spautin-1 to Entail the Discovery of Novel NEK4 Inhibitors. | Elsocht, M., et al. 2021. Int J Mol Sci. 22: PMID: 33435251
- Inhibition of ubiquitin-specific protease 13-mediated degradation of Raf1 kinase by Spautin-1 has opposing effects in naïve and primed pluripotent stem cells. | Wang, X., et al. 2021. J Biol Chem. 297: 101332. PMID: 34688658
- Spautin-1 inhibits mitochondrial complex I and leads to suppression of the unfolded protein response and cell survival during glucose starvation. | Kunimasa, K., et al. 2022. Sci Rep. 12: 11533. PMID: 35798783
- Spautin-1 Protects Against Mild TBI-Induced Anxiety-Like Behavior in Mice via Immunologically Silent Apoptosis. | Miao, HT., et al. 2023. Neuromolecular Med. 25: 336-349. PMID: 36745326
- Spautin-1 administration mitigates mild TBI-induced cognitive and memory dysfunction in mice via activation of caspase-3. | Zhang, LM., et al. 2023. Int Immunopharmacol. 117: 109906. PMID: 36822083
- Inhibition of USP10 induces myeloma cell apoptosis by promoting cyclin D3 degradation. | Xu, YJ., et al. 2023. Acta Pharmacol Sin. 44: 1920-1931. PMID: 37055530
- SPAUTIN-1 alleviates LPS-induced acute lung injury by inhibiting NF-κB pathway in neutrophils. | Wen, H., et al. 2024. Int Immunopharmacol. 130: 111741. PMID: 38394887
Inhibitor of:
13orf18_5031414D18Rik, 5330417C22Rik, 5430411K18Rik, 9930039A11Rik, AFAP-110, AMBRA1, APG7, AQR, ARMC6, Atg10, Atg12, Atg16, Atg16L2, Atg2A, Atg2B, Atg3, Atg4b, Atg4D, Atg9a, BECN1L1, C11orf60, C11orf74, C12orf44, C6orf130, C6orf72, C9orf72, CALCOCO1, CD63, Ceramide Synthase (CERS; LASS), CHAC2, CHMP1B, CHMP2B, CHMP4B, CLEC-16A, CLN3, cortexin 3, cryptdin 5, CUL-3, Cvt19, D030074E01Rik, D2Bwg1335e, D4Ertd196e, DLN1, DPEP2, DRAM2, DUB1, DUB1A, DUB2, DUB2A, ECSIT, EVA1B, EVA1C, FAM169B, FIG4, FMVB12B, FOXO1, FYCO1, GABARAP, GABARAPL1, GABARAPL2, GAP-assoc p62, GIMAP6, Gm104, GRAMD1C, HAUSP, HPS-6, Hrs, iASPP, IRGM, IRGM (immunity-related GTPase family M), ITM2B, KCTD21, KIAA0146, KIAA0226, KIAA0652, LAPTM5, LARP2, LASS4, LCHN_E330009J07Rik, LOC100041076, LULL1, Mac-3, MAP LC3α, MAP LC3β, MAP LC3β2, MAP LC3γ, MAP-1S, MBOAT1, MTMR14, Nap-22, Nix, NRBF2, Olfr510, Olfr512, Olfr513, Olfr514, Olfr516, Olfr517, Olfr530, Olfr531, Olfr532, Olfr533, Olfr535, OTUB2, PACRG, Peg12, PGAM5, PHF14, PIG11, PLEKHF1, PLEKHM2, PRH2, PSM, Rab 10, Rab L5, RB1CC1, Ribosomal Protein L13A, RSPH10B, sentan, SLC38A9, SMCR8, SMG9, SMPX, SorLA, SQSTM1-L1, Syntaxin 17, TATDN3, TBC1D14, TBC1D21, TBC1D25, TBC1D5, TBC1D9, TECPR1, TECPR2, TINAGL1, TMEM106B, TMEM167, TMEM212, TMEM41A, TMEM45B, TMEM49, TMEM62, TRIM16, TRIM38, TTC15, TTC33, TXR1, UBAP1, UBAP2, UBL7, UCH-L4, UFM1, ULK2, UPF0493, USP24, USP32, USP35, USP36, USP46, USP9X, UVRAG, V1RI9, VCPIP1, VMP1, VPS13C, Vps34, VPS37, WBSCR17, WBSCR9, WDFY2, WDFY4, WDR40B, WDR47, WDTC1, WIPI-1, WIPI-2, WIPI-3, WIPI-4, ZCCHC24, ZFYVE1, ZFYVE16, ZFYVE19, ZFYVE28, Zic3, Zimp7, ZKSCAN3, and ZZZ3.Activator of:
Atg13, Atg4C, Atg9b, Aut7, BECN1L1, BLOS3, DRAM, EG368203, EVA1B, HGTD-P, KLHDC8B, LAPTM4A, Maspardin, MON1A, MVB12A, NBR1, PLEKHF2, PLEKHM1, Rab 24, Rab 26, Ribosomal Protein L37, SNX5, STCH, Strumpellin, UBPY, USP10, USP2, V-ATPase C1, VPS39, VPS41, WDFY1, and WDR91.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Spautin-1, 10 mg | sc-507306 | 10 mg | $165.00 |