Molecular structure of EPZ6438, CAS Number: 1403254-99-8
EPZ6438 (CAS 1403254-99-8)
Alternate Names:
N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-5-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-4-methyl-4′-(4-morpholinylmethyl)-[1,1′-biphenyl]-3-carboxamide; Tazemetostat
CAS Number:
1403254-99-8
Molecular Weight:
572.7
Molecular Formula:
C34H44N4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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EPZ6438 (CAS 1403254-99-8) References
- Discovery of IHMT-337 as a potent irreversible EZH2 inhibitor targeting CDK4 transcription for malignancies. | Mei, H., et al. 2023. Signal Transduct Target Ther. 8: 18. PMID: 36642705
- UHRF1/UBE2L6/UBR4-mediated ubiquitination regulates EZH2 abundance and thereby melanocytic differentiation phenotypes in melanoma. | Kuser-Abali, G., et al. 2023. Oncogene. 42: 1360-1373. PMID: 36906655
- Modulation of EZH2 Activity Induces an Antitumoral Effect and Cell Redifferentiation in Anaplastic Thyroid Cancer. | de Mello, DC., et al. 2023. Int J Mol Sci. 24: PMID: 37175580
- SAM-Competitive EZH2-Inhibitors Induce Platinum Resistance by EZH2-Independent Induction of ABC-Transporters. | Groß, E., et al. 2023. Cancers (Basel). 15: PMID: 37297005
- Pharmacological inhibition of human EZH2 can influence a regenerative β-like cell capacity with in vitro insulin release in pancreatic ductal cells. | Naina Marikar, S., et al. 2023. Clin Epigenetics. 15: 101. PMID: 37309004
- Design, synthesis and evaluation of EZH2-based PROTACs targeting PRC2 complex in lymphoma. | Xie, H., et al. 2023. Bioorg Chem. 140: 106762. PMID: 37572533
- Cellular senescence primes liver fibrosis regression through Notch-EZH2. | Song, P., et al. 2023. MedComm (2020). 4: e346. PMID: 37614965
- Regulation of EZH2 protein stability: new mechanisms, roles in tumorigenesis, and roads to the clinic. | Guo, Y., et al. 2024. EBioMedicine. 100: 104972. PMID: 38244292
- EZH2 inhibition reactivates epigenetically silenced FMR1 and normalizes molecular and electrophysiological abnormalities in fragile X syndrome neurons. | Fang, M., et al. 2024. Front Neurosci. 18: 1348478. PMID: 38449737
- Inhibition of EZH2 Reduces Aging-Related Decline in Interstitial Cells of Cajal of the Mouse Stomach. | Taheri, N., et al. 2024. Cell Mol Gastroenterol Hepatol. 101376. PMID: 38969206
Inhibitor of:
4930557A04Rik, AEBP2, AHDC1, ANKRD24, ASF1A, AU022751, BAF57, BPTF, BRWD3, CARM1, CHD (chromodomain helicase), CHD5, CHD7, CHD9, CRBP IV, DLD, DOT1L1, DPY-30, DUX3, E130012A19Rik, E430029J22Rik, EG385328, EG434797, ENX-2, EPC2, Evi-1, EZHIP, FAM136A, FOXF2, Histone cluster 1 H2AA, Histone cluster 1 H2AB, Histone cluster 1 H2AC, Histone cluster 1 H2AE, Histone cluster 1 H2AH, Histone cluster 1 H2AI, Histone cluster 1 H2AJ, Histone cluster 1 H2AK, Histone cluster 1 H2AL, Histone cluster 1 H2AM, Histone cluster 1 H2BA, Histone cluster 1 H2BB, Histone cluster 1 H2BC, Histone cluster 1 H2BE, Histone cluster 1 H2BF, Histone cluster 1 H2BG, Histone cluster 1 H2BH, Histone cluster 1 H2BI, Histone cluster 1 H2BJ, Histone cluster 1 H2BL, Histone cluster 1 H2BM, Histone cluster 1 H2BO, Histone cluster 1 H3A, Histone cluster 1 H3C, Histone cluster 1 H3D, Histone cluster 1 H3F, Histone cluster 1 H4G, Histone H2B, Histone H2BM, hIws1, HP1γ, kismet, L3MBTL, L3MBTL2, LMCD1, LMO1, LOC340094, LOC642892, Lyl-1, MBTD1, Mel-18, Menin, Mettl7a2-Higd1c, Mi2-β, MSL-1, MSL3L2, NSD3, Obox3, Olfr547, Olr1128, Olr1217, Olr561, Olr694, Paf1, PCGF5, Peg10, PHC1, PHC2, PHC3, PHF1, PHF19, PHF20, PHF20L1, PHF21A, PHF21B, Plectin, PRDM12, PRDM16, PRHOXNB, RCOR2, RG9MTD1, Rslcan-13, SCML2, SFMBT2, Six1, SMYD4, Snf2, SUV420H1, Trav12d-3, TRIM2, Trimethyl Histone H3, Trimethyl Histone H4, TSHZ1, TSPYL4, UTX, VPS72, ZFP605, ZNF165, ZNF236, ZNF267, ZNF274, ZNF397, ZNF536, ZNF709, ZNF71, ZNF740, ZNF806, ZNF81, ZNF853, ZSCAN1, and ZSCAN4D.Activator of:
1700011H14Rik, ACBP, ALG5, ASXL2, ASXL3, BAF53B, BAZ2B, BRD9, DDB1, Dnmt3a, DPF1, E430018J23Rik, EG236663, EZHIP, H3-K9-HMTase, Histone cluster 1 H2AN, Histone cluster 1 H2BH, Histone cluster 1 H4J, HP1, L3MBTL3, Lamin A, LEUTX, LRRC4B, MAGE-A4, MAGE-A6, MLLT6, MPc3_CBX8, MSL3L1, NSD1, PCGF6, PHF8, R-Spondin, RIOK2, Set2, SETBP1, SNAPC 45, TRAP100, TSPYL6, ZBTB38, ZFYVE28, and ZNF408.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
EPZ6438, 1 mg | sc-507456 | 1 mg | $66.00 |