Ypk2 Activators
Ypk2, a Ser/Thr protein kinase in yeast, is intricately associated with lipid metabolism, particularly the sphingolipid pathway. The above chemicals play crucial roles within this lipid-based signaling pathway. The dynamic balance of ceramides, sphingosines, and their derivatives, dictates the active state of Ypk2. For instance, ceramide, a foundational sphingolipid, can be metabolized to produce sphingoid long-chain bases (LCBs) like phytosphingosine. These LCBs are pivotal in the direct activation of Ypk2. Certain chemicals, such as Myriocin or Fumonisin B1, while acting as for particular enzymes in the pathway, can lead to a transient rise in LCBs or other intermediates that promote Ypk2 activation.
Furthermore, the intricate interplay of lipids within cellular signaling, demonstrated by compounds like Platelet-activating factor (PAF) and Lysophosphatidic acid (LPA), underscores the broader network of lipid mediators and their influence on Ypk2. Both PAF and LPA, while not directly part of the sphingolipid pathway, can modulate it indirectly through their effects on related lipid pathways. Such chemicals, when introduced, can create a cellular context where the conditions are ripe for Ypk2 activation. It's this intricate balance and cross-talk of various lipid species that makes the field of Ypk2 activation particularly captivating, offering diverse avenues for modulation and exploration.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
C2 Ceramide | 3102-57-6 | sc-201375 sc-201375A | 5 mg 25 mg | $124.00 $460.00 | 12 | |
Ceramide is an essential component in sphingolipid metabolism. By increasing ceramide levels, we can influence the production of LCBs, which are direct activators of Ypk2 in yeast. | ||||||
Phytosphingosine | 554-62-1 | sc-201385 sc-201385A | 5 mg 25 mg | $102.00 $427.00 | 4 | |
Phytosphingosine is a precursor of LCBs. It can be converted into LCBs in the cell, directly influencing the activation of Ypk2. | ||||||
Myriocin (ISP-1) | 35891-70-4 | sc-201397 | 10 mg | $150.00 | 8 | |
Myriocin is a powerful inhibitor of serine palmitoyltransferase, the key enzyme in sphingolipid synthesis. While primarily an inhibitor, in certain contexts, it can lead to a transient increase in LCBs before their levels drop, potentially leading to temporary Ypk2 activation. | ||||||
Fumonisin B1 | 116355-83-0 | sc-201395 sc-201395A | 1 mg 5 mg | $200.00 $680.00 | 18 | |
Fumonisin B1 inhibits ceramide synthase, affecting sphingolipid metabolism. This can potentially cause an accumulation of upstream metabolites like LCBs, indirectly promoting Ypk2 activation. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P is a downstream product of sphingosine and can indirectly influence the balance of LCBs and ceramides in the cell, possibly leading to Ypk2 activation under certain conditions. | ||||||
D609 | 83373-60-8 | sc-201403 sc-201403A | 5 mg 25 mg | $189.00 $575.00 | 7 | |
D609 is a phosphatidylcholine-specific phospholipase C inhibitor. By affecting phospholipid metabolism, it can indirectly influence sphingolipid synthesis, possibly leading to altered Ypk2 activity. | ||||||
D-erythro-Sphingosine | 123-78-4 | sc-3546 sc-3546A sc-3546B sc-3546C sc-3546D sc-3546E | 10 mg 25 mg 100 mg 1 g 5 g 10 g | $90.00 $194.00 $510.00 $2448.00 $9384.00 $15300.00 | 2 | |
A precursor in the sphingolipid pathway, its conversion can influence the levels of LCBs, playing a role in the activation of Ypk2. | ||||||
PAF C-16 | 74389-68-7 | sc-201009 sc-201009A | 5 mg 25 mg | $131.00 $300.00 | 10 | |
PAF can influence various lipid signaling pathways and may have an indirect effect on LCB production and, subsequently, Ypk2 activation. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $98.00 $341.00 | 50 | |
LPA is involved in various lipid signaling pathways. Its role in sphingolipid metabolism can indirectly influence Ypk2 activation through LCB modulation. | ||||||
SEW2871 | 256414-75-2 | sc-203251 sc-203251A | 5 mg 10 mg | $38.00 $53.00 | 1 | |
SEW2871 is a selective S1P1 agonist. By modulating S1P signaling, it can indirectly influence LCB levels and potential Ypk2 activation. | ||||||