Molecular structure of C2 Ceramide, CAS Number: 3102-57-6
C2 Ceramide (CAS 3102-57-6)
See product citations (12)
Alternate Names:
C2 Ceramide is also known as D-erythro-Sphingosine, N-Acetyl.
Application:
C2 Ceramide is a ser/thr protein phosphatase activator and cell-permeable analog of naturally occurring ceramides.
CAS Number:
3102-57-6
Purity:
≥97%
Molecular Weight:
341.53
Molecular Formula:
C20H39NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
C2 Ceramide is a ceramide shown to be a potent modulator of proliferation and differentiation, used as a tool for studying the complex signaling associated with the ceramides. N-Acetyl-D-sphingosine and other ceramides like C2 ceramide are shown to activate a cystolic serine/threonine protein phosphatase, and mediate other biological activities. The main ceramide-activated protein phosphatase was isolated and identified as trimeric and dimeric PP2A. The sphingomyelin pathway, which generates ceramides like C2 ceramide as second messengers, is thought to mediate apoptosis in response to TNF-α through the stress-activated protein kinase (SAPK/JNK) signaling system. C2 Ceramide is a potential activator of ERK 2, PP1, and PP2.
C2 Ceramide (CAS 3102-57-6) References
- Inhibition of PKB/Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells. | Salinas, M., et al. 2000. Mol Cell Neurosci. 15: 156-69. PMID: 10673324
- Pituitary adenylate cyclase-activating polypeptide prevents C2-ceramide-induced apoptosis of cerebellar granule cells. | Vaudry, D., et al. 2003. J Neurosci Res. 72: 303-16. PMID: 12692897
- On the presence of C2-ceramide in mammalian tissues: possible relationship to etherphospholipids and phosphorylation by ceramide kinase. | Van Overloop, H., et al. 2007. Biol Chem. 388: 315-24. PMID: 17338639
- Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis. | Parra, V., et al. 2008. Cardiovasc Res. 77: 387-97. PMID: 18006463
- Anti-inflammatory mechanism of exogenous C2 ceramide in lipopolysaccharide-stimulated microglia. | Jung, JS., et al. 2013. Biochim Biophys Acta. 1831: 1016-26. PMID: 23384839
- Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation. | Okazaki, T., et al. 1990. J Biol Chem. 265: 15823-31. PMID: 2394750
- Sphingomyelinase and ceramide activate mitogen-activated protein kinase in myeloid HL-60 cells. | Raines, MA., et al. 1993. J Biol Chem. 268: 14572-5. PMID: 7686898
- Ceramide activates heterotrimeric protein phosphatase 2A. | Dobrowsky, RT., et al. 1993. J Biol Chem. 268: 15523-30. PMID: 8393446
- Programmed cell death induced by ceramide. | Obeid, LM., et al. 1993. Science. 259: 1769-71. PMID: 8456305
- Biosynthesis of N-acetylsphingosine by platelet-activating factor: sphingosine CoA-independent transacetylase in HL-60 cels. | Lee, TC., et al. 1996. J Biol Chem. 271: 209-17. PMID: 8550561
- Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. | Verheij, M., et al. 1996. Nature. 380: 75-9. PMID: 8598911
- Requirement of an ICE-like protease for induction of apoptosis and ceramide generation by REAPER. | Pronk, GJ., et al. 1996. Science. 271: 808-10. PMID: 8628997
- Ceramide-induced translocation of protein kinase C-delta and -epsilon to the cytosol. Implications in apoptosis. | Sawai, H., et al. 1997. J Biol Chem. 272: 2452-8. PMID: 8999958
Inhibitor of:
ASAH3, C7orf47, caveolin-3, CCDC25, CD1B, Cd1d2, CERKL, DGK-β, p55 CDC, PIG-K, RAIDD, SUSD3, and ZDHHC11B.Activator of:
β-1,4-Gal-T2, 1500002O20Rik, 3BP1, 4930539E08Rik, 5330437I02Rik, 9130409I23Rik, 9430007A20Rik, ABHD9, ACBD5, AIF, Alpha 4, Annexin V, Annexin XI, ANXA8L2, AP1, APHC, apoAL, ASAH2C, ASAH3, ATF-3, BI-1, c-Jun, CAB39L, caspase-13, caspase-8, caveolin-2, CD1B, Cd59b, Cks2, cPKC α, cPKC βI, cPKC γ, CRP, CRS4C-5, CWH43, Cytokeratin 1, Cytokeratin 17, Cytokeratin 23, dachsous, DDHD1, demethylated-PP2A-C, DGK-δ, DGK-ι, DGK-κ, DGK-θ, DSCR 5, dsg4, EG629667, epsin2, ERK 2, Esophagin, FAK, FAM57A, FAPP2, FBF1, Fbxo12, Fc ε RIα, Flotillin-1, Flotillin-2, Gα 12, Ganglioside GD3, GD3 Synthase, GDPD4, Ggnbp2, GLTPD1, GLTPD2, GM2-AP, group IID sPLA2, Hantavirus, HemT-1, Hep C E1, Hep C E2, Hippi, HPS-3, ICAD, iGb3, IGLON5, IKKα, IKKβ, Influenza A m1, JNK2, Keratin 73, KLKBL4, KRTAP13, KRTAP19, LASS2, LASS5, Lce1j, LECT2, LOC284274, LOC339674, LPAAT-γ, LPCAT1, LPPR2, LPPR4, MAFbx, MASP-1, Measles H, MEK kinase-4, MLK3, MOAP1, MTMR4, myotubularin, N-SMase, Nek10, neutral ceramidase, NFκB p65, Nir1, Nucling, ORMDL1, ORP-6, ORP-8, ORP-9, OSBP2, p38, p38 α, p38β, PAP-2c, PDZK3, PGAP1, PI 4-kinase II β, PIG-preY, PKC delta, PKC eta, PLSCR3, POPX2, PP1, PP2, PP2A-β, PP2A-δ, PP2A-B55-γ, PP2A-B56-δ, PP2A-B72/B130, PRSS51, PSAPL1, Pseudo, Psg22, RelA, RELT, Ribosomal Protein L14, RILPL2, Ripply2, RNF103, RP11-307F22.3, SAA1, SAP-1, saposin, SERINC1, Siglec-1, SMPD5, SNAP 23, SO, SPCS2, SPCS3, SphK1, SPRR4, SPTSSA, Syk, Synaptotagmin VIII, T-cadherin, TM7SF3, TMEM41B, VPS13A, VPS13C, XIAP, Ypk2, ZDHHC24, ZDHHC7, and ZPLD1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
C2 Ceramide, 5 mg | sc-201375 | 5 mg | $77.00 | |||
C2 Ceramide, 25 mg | sc-201375A | 25 mg | $316.00 |