Molecular structure of PAF C-16, CAS Number: 74389-68-7
PAF C-16 (CAS 74389-68-7)
See product citations (10)
Alternate Names:
3-sn-Phosphatidylcholine, 1-hexadecyl-2-acetyl; Platelet activating factor C 16;1-O-hexadecyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholine
Application:
PAF C-16 is a PAF-R, MAP kinase, and MAP kinase kinase activator
CAS Number:
74389-68-7
Purity:
≥98%
Molecular Weight:
523.7
Molecular Formula:
C26H54NO7P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PAF C-16 is a PAF-R (platelet activating factor receptor) activator and ligand for PAF-R with a C16 alkane group. It also acts as an extracellular signaling lipid. PAF C-16 may act to increase vascular permeability and thus induce inflammation. Additionally, it has been reported to activate MAP kinase (MAPK) and MEK (MAP kinase kinase, MAPKK) in CHO cells.
PAF C-16 (CAS 74389-68-7) References
- Antiinflammatory and antiallodynic actions of the lignan niranthin isolated from Phyllanthus amarus. Evidence for interaction with platelet activating factor receptor. | Kassuya, CA., et al. 2006. Eur J Pharmacol. 546: 182-8. PMID: 16925995
- Small bowel injury associated to allergy is triggered by platelet-activating factor, mast cells, neutrophils and protected by nitric oxide. | Kwasniewski, FH., et al. 2008. Int Immunopharmacol. 8: 371-8. PMID: 18182253
- The role of ET(A) and ET(B) receptor antagonists in acute and allergic inflammation in mice. | Kassuya, CA., et al. 2008. Peptides. 29: 1329-37. PMID: 18632188
- Platelet-activating factor. | Prescott, SM., et al. 1990. J Biol Chem. 265: 17381-4. PMID: 2170377
- Characterization of a receptor for human monocyte-derived neutrophil chemotactic factor/interleukin-8. | Grob, PM., et al. 1990. J Biol Chem. 265: 8311-6. PMID: 2186041
- Interleukin-6 production by tumor necrosis factor and lipopolysaccharide-stimulated rat renal cells. | Pirotzky, E., et al. 1990. Clin Immunol Immunopathol. 56: 271-9. PMID: 2199100
- [Serum metabolomics analysis on benign prostate hyperplasia in mice based on liquid chromatography-mass spectrometry]. | Geng, Y., et al. 2014. Se Pu. 32: 1301-5. PMID: 25902635
- Bacterial exploitation of phosphorylcholine mimicry suppresses inflammation to promote airway infection. | Hergott, CB., et al. 2015. J Clin Invest. 125: 3878-90. PMID: 26426079
- Platelet activating factor; chemical and biochemical characteristics. | Hanahan, DJ. and Kumar, R. 1987. Prog Lipid Res. 26: 1-28. PMID: 3313430
- Egg components reverse the atrophy induced by injury in skeletal muscles. | Sawano, S., et al. 2022. Genes Cells. 27: 138-144. PMID: 34929062
- High-Content Imaging Platform to Discover Chemical Modulators of Plasma Membrane Rafts. | Fricke, N., et al. 2022. ACS Cent Sci. 8: 370-378. PMID: 35355811
- Comparative Metabolomics and Lipidomics of Four Juvenoids Application to Scylla paramamosain Hepatopancreas: Implications of Lipid Metabolism During Ovarian Maturation. | Fu, Y., et al. 2022. Front Endocrinol (Lausanne). 13: 886351. PMID: 35574001
- Characteristics of 1-O-hexadecyl- and 1-O-octadecyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholine-stimulated granule enzyme release from human neutrophils. | Smith, RJ., et al. 1983. Clin Immunol Immunopathol. 28: 13-28. PMID: 6872358
- Blood cardiolipin in haemodialysis patients. Its implication in the biological action of platelet-activating factor. | Antonopoulou, S., et al. 1996. Int J Biochem Cell Biol. 28: 43-51. PMID: 8624843
- Guanine nucleotide regulatory proteins, Gq and Gi1/2, mediate platelet-activating factor-stimulated phosphoinositide metabolism in immortalized hippocampal cells. | Shi, LC., et al. 1996. J Neurochem. 67: 1478-84. PMID: 8858930
Inhibitor of:
2610005M20Rik.Activator of:
β thromboglobulin, 2310033E01Rik, azurocidin, CD42c, CRP, dsg4, E-Selectin, eotaxin-3, FAM57A, Fpr-rs4, G2A, GRO1, group II sPLA2, group IIC sPLA2, group IID sPLA2, group III sPLA2, group IVC sPLA2, group V PLA2, group XIIB sPLA2, HNP-3, iPLA2, LPLUNC1, MEK, MS4A8B, NPP6, p40-phox, PAF acetylhydrolase 2, PAF-R, PC-PLD, PLA2G4B, Rootletin, TMEM41B, UNC119B, Uqcr, and Ypk2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PAF C-16, 5 mg | sc-201009 | 5 mg | $131.00 | |||
PAF C-16, 25 mg | sc-201009A | 25 mg | $300.00 |