Ypk2 Inhibitors
Ypk2 inhibitors mainly target upstream kinases or signaling complexes that contribute to the phosphorylation and subsequent activation of Ypk2. For instance, Wortmannin and LY294002 act as PI3K inhibitors and thereby attenuate PDK1 activity, which is essential for Ypk2 phosphorylation and activation. This precise mechanism of action ensures that Ypk2 remains in a less active state, impacting downstream processes like lipid metabolism and cell survival pathways that are under the regulatory control of Ypk2. GSK2334470 and UCN-01 are PDK1-specific inhibitors that phosphorylation at key activation sites on Ypk2, rendering it enzymatically inactive.
Another significant set of compounds like Rapamycin, KU-0063794, and PP242 inhibit mTOR complexes, particularly TORC2, which is a direct of Ypk2. By blocking TORC2-mediated phosphorylation, these inhibitors substantially curtail Ypk2 activation. In addition, MK-2206 operates through Akt inhibition, reducing feedback loops that would otherwise upregulate PDK1 and subsequently Ypk2. Some inhibitors like NVP-BEZ235 exhibit dual inhibitory effects on both PI3K and mTOR, providing a comprehensive blockage of Ypk2 activation pathways. This diversification in targeting allows for a broader, yet specific, inhibition of the enzymatic functions of Ypk2.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
PI3K inhibitor that suppresses the activation of PDK1, an upstream activator of Ypk2. Inhibits PDK1-mediated phosphorylation and activation of Ypk2. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Binds to FKBP12 and inhibits TORC2, which is a direct activator of Ypk2. Blocks Ypk2 activation by interfering with TORC2-mediated phosphorylation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Inhibits PI3K, thereby reducing PDK1 activity, which is necessary for Ypk2 phosphorylation and activation. | ||||||
GSK 2334470 | 1227911-45-6 | sc-364501 sc-364501A | 10 mg 50 mg | $199.00 $1165.00 | 1 | |
PDK1 inhibitor that prevents phosphorylation and subsequent activation of Ypk2. | ||||||
UCN-01 | 112953-11-4 | sc-202376 | 500 µg | $251.00 | 10 | |
Inhibits PDK1 and thus attenuates Ypk2 activation by preventing its phosphorylation. | ||||||
KU 0063794 | 938440-64-3 | sc-361219 | 10 mg | $209.00 | ||
mTOR inhibitor affecting both TORC1 and TORC2. Inhibition of TORC2 leads to reduced phosphorylation and activation of Ypk2. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
General kinase inhibitor that can also inhibit PDK1, leading to diminished phosphorylation and activation of Ypk2. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $57.00 $172.00 | 8 | |
mTOR inhibitor that selectively blocks the activity of TORC2, leading to inhibition of Ypk2 phosphorylation and activation. | ||||||
MK-2206 dihydrochloride | 1032350-13-2 | sc-364537 sc-364537A | 5 mg 10 mg | $182.00 $332.00 | 67 | |
Akt inhibitor that reduces feedback activation of PDK1, indirectly affecting Ypk2 activation. | ||||||
AZD8055 | 1009298-09-2 | sc-364424 sc-364424A | 10 mg 50 mg | $163.00 $352.00 | 12 | |
mTOR inhibitor that blocks both TORC1 and TORC2, reducing phosphorylation and subsequent activation of Ypk2. | ||||||