Molecular structure of UCN-01, CAS Number: 112953-11-4
UCN-01 (CAS 112953-11-4)
See product citations (10)
Alternate Names:
7-hydroxystaurosporine
Application:
UCN-01 is a selective inhibitor of protein kinase C
CAS Number:
112953-11-4
Purity:
>95%
Molecular Weight:
482.53
Molecular Formula:
C28H26N4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
UCN-01 is a Staurosporine (sc-3510) analogue that acts as a selective inhibitor of protein kinase C and is reported to potently inhibit MK2. The compound may act to induce UCN-01 G1 phase accumulation, dephosphorylate Rb and CDK2 proteins, and induce CDK inhibitor p21/Cip1/WAF1/Sdi1 in A431 (sc-2201) cells with mutated p53. Additionally, UCN-01 has been demonstrated to suppress protein expression of thymidylate synthase and E2F-1, inhibit DNA damage checkpoint kinase hChk1, and interrupt the PDK1-Akt survival signaling pathway. UCN-01 has also been noted to inhibit cell proliferation in HNSCC cells. It effectively suppresses the activity of various kinases, such as Akt, protein kinase C (IC50 = 30 nM), PDK1 (IC50 = 6 nM), and cyclin-dependent kinases (with IC50 values ranging from 300-600 nM for Cdk1 and Cdk2).
UCN-01 (CAS 112953-11-4) References
- The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1. | Busby, EC., et al. 2000. Cancer Res. 60: 2108-12. PMID: 10786669
- UCN-01 suppresses E2F-1 mediated by ubiquitin-proteasome-dependent degradation. | Hsueh, CT., et al. 2001. Clin Cancer Res. 7: 669-74. PMID: 11297263
- Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine). | Sato, S., et al. 2002. Oncogene. 21: 1727-38. PMID: 11896604
- Antitumor activity of UCN-01 in carcinomas of the head and neck is associated with altered expression of cyclin D3 and p27(KIP1). | Patel, V., et al. 2002. Clin Cancer Res. 8: 3549-60. PMID: 12429646
- Inhibition of Chk1 by the G2 DNA damage checkpoint inhibitor isogranulatimide. | Jiang, X., et al. 2004. Mol Cancer Ther. 3: 1221-7. PMID: 15486189
- Hemodynamic regulation of myosin heavy chain gene expression. Studies in the transplanted rat heart. | Klein, I., et al. 1992. J Clin Invest. 89: 68-73. PMID: 1729282
- UCN-01 (7-hydroxystaurosporine) induces apoptosis and G1 arrest of both primary and metastatic oral cancer cell lines in vitro. | Otsubo, A., et al. 2007. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 103: 391-7. PMID: 17321452
- UCN-01, a selective inhibitor of protein kinase C from Streptomyces. | Takahashi, I., et al. 1987. J Antibiot (Tokyo). 40: 1782-4. PMID: 3429345
- Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue. | Seynaeve, CM., et al. 1994. Mol Pharmacol. 45: 1207-14. PMID: 8022414
- G1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated human epidermoid carcinoma A431 cells. | Akiyama, T., et al. 1997. Cancer Res. 57: 1495-501. PMID: 9108451
- 7-Hydroxystaurosporine (UCN-01) causes redistribution of proliferating cell nuclear antigen and abrogates cisplatin-induced S-phase arrest in Chinese hamster ovary cells. | Bunch, RT. and Eastman, A. 1997. Cell Growth Differ. 8: 779-88. PMID: 9218872
- 7-Hydroxystaurosporine (UCN-01) induces apoptosis in human colon carcinoma and leukemia cells independently of p53. | Shao, RG., et al. 1997. Exp Cell Res. 234: 388-97. PMID: 9260909
- UCN-01 suppresses thymidylate synthase gene expression and enhances 5-fluorouracil-induced apoptosis in a sequence-dependent manner. | Hsueh, CT., et al. 1998. Clin Cancer Res. 4: 2201-6. PMID: 9748140
Inhibitor of:
14-3-3 β, 2410076I21Rik, ATAD5, C1D, C1orf55, Cadherin (CDH), CARF, Cdc123, Cdc14, Cdc14a phosphatase, Cdc2, Cdc45, Chk1, Cks1, cPKC γ, CWF19L1, CWF19L2, DFF-45, DNA pol ζ, Etaa1, EVI5L, F730047E07Rik, GADD 45α, Ggnbp2, Gm355, hCG_1645220, Inv, KIAA1530, MASTL, Mcpr1, MST-4, OTTMUSG00000005737, p73α, PAR-3, PC-PLD4, PGBD2, PITSLRE B, PKC beta, Pkc1, Polyoma virus large T antigen, Rad24, RDM1, RFC3, SCAI, Scc1, Ser/Thr Protein Kinase, Spartan, Speedy A, Ste20 (sterile 20) Serine/Threonine Kinase (STK), TFIIH p89, Timeless, TIPIN, TLK2, TopBP1, Tropomyosin β, VPRBP, Ypk2, and YY1AP1.Activator of:
AIP2, Cdc25C, Cdc40, Cdc5, CENP-F, EBV LMP-1, HELIC1, ICAD, MAD1, MAD2L1BP, MCAF2, MCM-BP, MCM10, MUS81, Nek1, PITSLRE A, PTIP, Rad1, RPA16, SLX1A/B_SLX1, TLK1, and Treslin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UCN-01, 500 µg | sc-202376 | 500 µg | $246.00 |