UCN-01 CAS: 112953-11-4
MF: C28H26N4O4
MW: 482.53
A selective inhibitor of protein kinase C.

UCN-01 (CAS 112953-11-4)

UCN-01 | CAS 112953-11-4 is rated 5.0 out of 5 by 1.
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Alternate Names: 7-hydroxystaurosporine
Application: UCN-01 is a selective inhibitor of protein kinase C
CAS Number: 112953-11-4
Purity: >95%
Molecular Weight: 482.53
Molecular Formula: C28H26N4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
DISCOUNT: Bulk orders of Chemicals totaling $1,000 or more receive a 5% discount.
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UCN-01 is a Staurosporine (sc-3510) analogue that acts as a selective inhibitor of protein kinase C and is reported to potently inhibit MK2. The compound has been shown to induce UCN-01 G1 phase accumulation, dephosphorylate Rb and CDK2 proteins, and induce CDK inhibitor p21/Cip1/WAF1/Sdi1 in A431 (sc-2201) cells with mutated p53. Additionally, UCN-01 has been demonstrated to suppress protein expression of thymidylate synthase and E2F-1, inhibit DNA damage checkpoint kinase hChk1, and interrupt the PDK1-Akt survival signaling pathway. UCN-01 has also been noted to inhibit cell proliferation in HNSCC cells.


References

1. Takahashi, I., et al. 1987. J. Antibiot. 40: 1782-1784. PMID: 3429345
2. Klein, I., et al. 1992. J. Clin. Invest. 89: 68-73. PMID: 1729282
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4. Akiyama, T., et al. 1997. Cancer Res. 57: 1495-1501. PMID: 9108451
5. Hsueh, C.T., et al. 1998. Clin. Cancer Res. 4: 2201-2206. PMID: 9748140
6. Busby, E.C., et al. 2000. Cancer Res. 60: 2108-2112. PMID: 10786669
7. Hsueh, C.T., et al. 2001. Clin. Cancer Res. 7: 669-674. PMID: 11297263
8. Patel, V., et al. 2002. Clin. Cancer Res. 8: 3549-3560. PMID: 12429646
9. Sato, S., et al. 2002. Oncogene. 21: 1727-1738. PMID: 11896604
10. Jiang, X., et al. 2004. Mol. Cancer Ther. 3: 1221-1227. PMID: 15486189

Physical State :
Solid
Solubility :
Soluble in DMSO or EtOH.
Storage :
Store at 4° C
Melting Point :
314.42° C (Predicted)
Boiling Point :
717.98° C (Predicted)
Density :
1.6 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
C[[email protected]@]12[[email protected]@H]([[email protected]@H](C[[email protected]@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)[[email protected]](NC6=O)O)NC)OC

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UCN-01 (CAS 112953-11-4)  Product Citations

See how others have used UCN-01 (CAS 112953-11-4). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 10 total

PMID: # 25633853  Dong, J.|Wang, Z.|Zou, P.|Zhang, G.|Dong, X.|Ling, X.|Zhang, X.|Liu, J.|Ye, D.|Cao, J.|Ao, L.| et al. 2015. Chem Res Toxicol. 28: 518-31.

PMID: # 17540843  Pei, XY. et al. 2007. Blood. 110: 2092-2101.

PMID: # 15767555  Hahn, M. et al. 2005. Mol. Cancer Ther. 4: 457-470.

PMID: # 15548112  Mack, PC. et al. 2004. Radiat. Res. 162: 623-634.

PMID: # 12488556  Wang, S. et al. 2003. Mol. Pharmacol. 63: 232-242.

PMID: # 12399544  Zhao, H. et al. 2002. Proc. Natl. Acad. Sci. USA. 99(23): 14795-800.

PMID: # 12384435  Dai, Y. et al. 2002. Blood. 100: 3333-3343.

PMID: # 10577141  Chen, X. et al. 1999. Oncogene. 18: 5691-5702.

PMID: # 9837924  Yu, L. et al. 1998. J. Biol. Chem. 273: 33455-33464.

PMID: # 29511342  Cell Death Differ. 1967-1979.

Citations 1 to 10 of 10 total
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Rated 5 out of 5 by from Pei Pei, et. al. (PubMed ID 17540843) utilized UCN-01 to increase ERK 1/2 phosphorylation in U266 cells. -SCBT Publication Review
Date published: 2015-07-20
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