GSK 2334470 CAS: 1227911-45-6
MF: C25H34N8O
MW: 462.59
A potent and selective PDK1 inhibitor that subsequently induces apoptotic cell death.

GSK 2334470 (CAS 1227911-45-6)

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Alternate Names: (3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide
Application: GSK 2334470 is a potent and selective PDK1 inhibitor that subsequently induces apoptotic cell death
CAS Number: 1227911-45-6
Purity: ≥99%
Molecular Weight: 462.59
Molecular Formula: C25H34N8O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

GSK 2334470 is a potent and highly selective PDK1 inhibitor (IC50 ~ 10nM). This compound exhibits no effect on a variety of other kinases, including Aurora, ROCK, p38 MAPK and PI3K. This compound also suppresses T-loop phosphorylation and subsequent activation of PDK1 substrates S6K1, SGK, and RSK in HEK 293, U87, and mouse embryonic fibroblast cell lines. The selectivity of GSK 2334470 allows for determination of the role of PDK1 in various cell lines, including cancerous cell lines. This compound also has a limited inhibitory effect on Akt activation.

Physical State :
Solid
Storage :
Store at -20° C
Density :
~1.3 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
46215815
SMILES :
C[[email protected]@H]1CC[[email protected]@H](CN1C2=NC(=NC(=C2)C3=CC4=C(C=C3)C(=NN4)N)NC)C(=O)NC5CCCCC5

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Certificate of Analysis

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GSK 2334470 (CAS 1227911-45-6)  Product Citations

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PMID: # 32385243  Nat Commun. 11: 2291.

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