Molecular structure of Myriocin (ISP-1), CAS Number: 35891-70-4
Myriocin (ISP-1) (CAS 35891-70-4)
See product citations (8)
Alternate Names:
Thermozymocidin;(2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid
Application:
Myriocin (ISP-1) is an inhibitor of sphingolipid biosynthesis with immunosuppressive properties
CAS Number:
35891-70-4
Purity:
≥95%
Molecular Weight:
401.54
Molecular Formula:
C21H39NO6
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Myriocin, also known as ISP-1, is a compound extensively studied in biological research due to its potent inhibitory effect on serine palmitoyltransferase, the key enzyme in sphingolipid biosynthesis. Its role in sphingolipid metabolism makes it useful in cellular studies aimed at understanding the complex signaling pathways influenced by sphingolipids. Myriocin is also investigated for its impact on the immune system, particularly in relation to the proliferation of various immune cells through the modulation of lipid-mediated signaling. In the field of microbiology, Myriocin is used to explore fungal physiology and biochemistry, as it was originally found in the thermophilic fungus Mycelia sterilia. Environmental and agricultural research utilize Myriocin to study its presence and degradation in ecosystems, and its potential effects on microbial communities in soil and plant systems.
Myriocin (ISP-1) (CAS 35891-70-4) References
- Serine palmitoyltransferase inhibitor suppresses HCV replication in a mouse model. | Umehara, T., et al. 2006. Biochem Biophys Res Commun. 346: 67-73. PMID: 16750511
- Intratracheal myriocin enhances allergen-induced Th2 inflammation and airway hyper-responsiveness. | Edukulla, R., et al. 2016. Immun Inflamm Dis. 4: 248-62. PMID: 27621809
- Novel ophthalmic formulation of myriocin: implications in retinitis pigmentosa. | Platania, CBM., et al. 2019. Drug Deliv. 26: 237-243. PMID: 30883241
- Myriocin Effect on Tvrm4 Retina, an Autosomal Dominant Pattern of Retinitis Pigmentosa. | Piano, I., et al. 2020. Front Neurosci. 14: 372. PMID: 32435178
- Myriocin modulates the altered lipid metabolism and storage in cystic fibrosis. | Signorelli, P., et al. 2021. Cell Signal. 81: 109928. PMID: 33482299
- Myriocin Treatment Reverses Alcohol-Induced Alterations in Polyunsaturated Fatty Acid-Containing Phospholipid Expression in the Liver. | Yalcin, EB., et al. 2022. Nutr Metab Insights. 15: 11786388221082012. PMID: 35250275
- Lipidomics Analysis Reveals a Protective Effect of Myriocin on Cerebral Ischemia/Reperfusion Model Rats. | Wang, T., et al. 2022. J Mol Neurosci. 72: 1846-1858. PMID: 35776315
- Inhibitory Effects of Myriocin on Non-Enzymatic Glycation of Bovine Serum Albumin. | He, L., et al. 2022. Molecules. 27: PMID: 36296589
- Myriocin enhances the antifungal activity of fluconazole by blocking the membrane localization of the efflux pump Cdr1. | Wang, H., et al. 2022. Front Pharmacol. 13: 1101553. PMID: 36618949
- Insulin-regulated serine and lipid metabolism drive peripheral neuropathy. | Handzlik, MK., et al. 2023. Nature. 614: 118-124. PMID: 36697822
- Therapeutic Effects of Myriocin in Experimental Alcohol-Related Neurobehavioral Dysfunction and Frontal Lobe White Matter Biochemical Pathology. | Homans, C., et al. 2022. J Behav Brain Sci. 12: 23-42. PMID: 36815096
- Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin. | Miyake, Y., et al. 1995. Biochem Biophys Res Commun. 211: 396-403. PMID: 7794249
- Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite. | Fujita, T., et al. 1994. J Antibiot (Tokyo). 47: 208-15. PMID: 8150717
- Dual roles of sphingolipids in signaling of the escape from and onset of apoptosis in a mouse cytotoxic T-cell line, CTLL-2. | Nakamura, S., et al. 1996. J Biol Chem. 271: 1255-7. PMID: 8576106
- Complete removal of sphingolipids from the plasma membrane disrupts cell to substratum adhesion of mouse melanoma cells. | Hidari KIPJ, ., et al. 1996. J Biol Chem. 271: 14636-41. PMID: 8662871
Inhibitor of:
4932441B19Rik, 9130409I23Rik, Alk-SMase, APHC, ASAH2B, ASAH3, ASAH3L, Cd1d2, Cdc11, CDS1, Ceramide Kinase, CERKL, CHPT1, CstF-50, CTDSP1, DC-SIGNR, DES2, EG629667, FADS7_Degs1, Forssman Antigen, Gbp10, GLTPD1, GPAA1, KLC, LASS1, LASS2, LASS3, LASS4, N-SMase, N-SMase3, neutral ceramidase, ORMDL2, ORMDL3, PE, PIG-A, PIG-N, Ribosomal Protein L15, Ribosomal Protein S26, SAMD8, saposin, SCD3, SCD4, Sec23IP, SMPD5, SPDL-1, Sphingomyelin Synthase 2, SPT1, SPTLC, SPTLC1, SPTLC2, SPTSSA, and SUSD3.Activator of:
ASAH2C, Dcp1, EG629667, GD3 Synthase, LASS2, LASS5, LPPR2, LPPR4, MORN4, ORMDL1, PGAP1, PIG-C, PIG-L, PIG-W, PIG-X, PPT2, PSAPL1, SEC14L5, SMPDL3B, SMS1, SMS2, TGE Virus, TL, UGCG, Ypk2, ZDHHC11, ZDHHC23, and ZDHHC9.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Myriocin (ISP-1), 10 mg | sc-201397 | 10 mg | $150.00 |