XAF1 Activators
The chemical class referred to as XAF1 Activators encompasses a range of compounds that can influence cellular signaling pathways, stress responses, or gene expression mechanisms leading to the activation or increased expression of XAF1. These compounds do not activate XAF1 directly but can create cellular conditions that lead to its upregulation, primarily through the modulation of apoptosis, DNA damage response, or cellular stress pathways. Many of these chemicals function by influencing epigenetic regulation, such as DNA methylation and histone acetylation, which can lead to an increase in XAF1 expression.
Several of these activators interact with major signaling cascades, such as the PI3K/Akt, MAPK/ERK, and NF-κB pathways. By either inhibiting or stimulating these pathways, the activators can create a cellular environment that favors the expression of tumor suppressor genes, including XAF1. For instance, inhibiting the PI3K/Akt pathway with compounds like LY294002 or quercetin can remove survival signals, which might contribute to the elevation of pro-apoptotic factors such as XAF1. Conversely, compounds like sulforaphane that activate the Nrf2 pathway can enhance the expression of genes involved in cellular defense mechanisms, potentially including XAF1 as a response to oxidative stress.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol can activate sirtuin 1 (SIRT1), which is involved in stress response. SIRT1 activation can lead to deacetylation of p53, enhancing its stability and activity, potentially upregulating XAF1 transcription. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein acts as an isoflavone that influences gene expression through epigenetic modifications. It could enhance XAF1 expression by demethylating its promoter region. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane can activate Nrf2, leading to an increase in antioxidant response elements and can induce XAF1 expression as part of the cellular stress response. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is known to modulate multiple signaling pathways, including NF-κB, which can lead to increased XAF1 expression as part of the cell's effort to counteract survival signals. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin can inhibit PI3K/Akt pathway, which may lead to a reduction in cell survival signaling and a compensatory rise in pro-apoptotic factors like XAF1. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
As a DNA methyltransferase inhibitor, this compound can cause hypomethylation of gene promoters, potentially increasing XAF1 expression by demethylating its promoter. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, can change chromatin structure and increase the transcription of certain genes, including potentially XAF1. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Similar to Trichostatin A, as a histone deacetylase inhibitor, it could upregulate XAF1 expression by altering histone acetylation and enhancing gene transcription. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc can modulate cellular pathways and has been shown to influence apoptosis. It may affect XAF1 indirectly by altering the cellular redox state and stress responses. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that could indirectly increase XAF1 expression by blocking the PI3K/Akt pathway, thus potentially attenuating cell survival signals and favoring apoptotic processes. | ||||||