Wnt-8a Inhibitors
Wnt-8a inhibitors are a class of chemical compounds that specifically target and inhibit the activity of the Wnt-8a protein, a key member of the Wnt family of glycoproteins involved in cell signaling. Wnt-8a is part of the canonical Wnt signaling pathway, which plays a significant role in regulating processes such as cell proliferation, differentiation, and migration. This pathway is particularly important in the early stages of embryonic development, where it controls the patterning and formation of tissues. Inhibition of Wnt-8a can affect the downstream signaling cascade, impacting β-catenin stabilization and transcriptional activity within the cell.
Structurally, Wnt-8a inhibitors can vary significantly, often involving small molecules that disrupt the interaction between Wnt-8a ligands and their receptors, such as Frizzled receptors or co-receptors like LRP5/6. These inhibitors may work by either directly binding to Wnt-8a or its associated receptors, thereby preventing Wnt-8a from initiating its signal transduction. By interfering with this specific signaling pathway, Wnt-8a inhibitors can modulate a wide range of cellular responses. The study of these inhibitors is crucial in understanding cellular mechanisms like gene expression regulation, cell fate determination, and tissue morphogenesis, particularly during development. Researchers often employ Wnt-8a inhibitors in various biological assays to dissect the roles of Wnt signaling components in both normal and abnormal cell behavior, offering insights into how precise signaling regulation affects cellular architecture and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By inhibiting DNA methyltransferase, 5-Azacytidine could cause hypomethylation of the Wnt-8a gene promoter, potentially leading to decreased expression of the Wnt-8a gene. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A may prompt histone hyperacetylation, which could result in the loosening of chromatin structure at the Wnt-8a locus and a subsequent reduction in Wnt-8a transcription. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride inhibits GSK-3β, thereby possibly leading to the stabilization of β-catenin and alteration of downstream target genes, which could include decreased transcriptional activation of Wnt-8a. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can bind to retinoic acid receptors, leading to altered expression of downstream target genes, which may result in the downregulation of Wnt-8a expression. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Cholecalciferol, through the vitamin D receptor, could repress the transcriptional activity of β-catenin target genes, potentially leading to a decrease in Wnt-8a expression levels. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin may downregulate Wnt-8a expression by inhibiting the activity of transcription factors specific to the Wnt-8a gene, resulting in decreased gene transcription. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein has been shown to inhibit the phosphorylation of proteins involved in Wnt signal transduction, which could lead to the downregulation of Wnt-8a expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin may decrease the expression of Wnt-8a by inhibiting the phosphorylation of key enzymes in the Wnt pathway, thereby reducing Wnt-8a promoter activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol could downregulate Wnt-8a by hindering the binding of transcription factors to the Wnt-8a promoter, resulting in lower levels of Wnt-8a mRNA. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane may reduce Wnt-8a expression by activating transcriptional repressors that bind to the Wnt-8a promoter, thereby inhibiting its transcription. | ||||||