Date published: 2026-1-8

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Wnt-8a Antibody (14-3): sc-80459

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Datasheets
  • Wnt-8a Antibody (14-3) is a rat monoclonal IgG2a Wnt-8a antibody provided at 100 µg/ml
  • raised against full length recombinant Wnt-8a of mouse origin
  • recommended for detection of Wnt-8a of mouse origin by WB and ELISA; non cross-reactive with Wnt-1, Wnt-3a, Wnt-5a or Wnt-10b
  • At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Wnt-8a Antibody (14-3). This work is in progress.

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    Wnt-8a Antibody (14-3) is a rat monoclonal IgG2a antibody that detects Wnt-8a of mouse origin by western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). Anti-Wnt-8a antibody (14-3) is available as the non-conjugated format. Wnt-8a plays a crucial role in regulating embryonic development and cell signaling pathways, particularly in the Wnt signaling pathway, which is essential for various cellular processes including cell proliferation, differentiation, and migration. This pathway is vital for proper organ development and tissue homeostasis, and dysregulation of Wnt signaling has been implicated in numerous diseases, including cancer. Wnt-8a is primarily expressed in the developing brain, particularly in the forebrain, where Wnt-8a influences the patterning and development of neural structures. The gene encoding Wnt-8a is located on human chromosome 10q24, and Wnt-8a expression is tightly regulated during development, highlighting Wnt-8a′s importance in both normal physiological processes and potential pathological conditions.

    For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

    Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

    LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

    Wnt-8a Antibody (14-3) References:

    1. Molecular cloning and characterization of human WNT8A.  |  Saitoh, T. and Katoh, M. 2001. Int J Oncol. 19: 123-7. PMID: 11408932
    2. Up-regulation of WNT8B mRNA in human gastric cancer.  |  Saitoh, T., et al. 2002. Int J Oncol. 20: 343-8. PMID: 11788899
    3. Expression and regulation of WNT8A and WNT8B mRNAs in human tumor cell lines: up-regulation of WNT8B mRNA by beta-estradiol in MCF-7 cells, and down-regulation of WNT8A and WNT8B mRNAs by retinoic acid in NT2 cells.  |  Saitoh, T., et al. 2002. Int J Oncol. 20: 999-1003. PMID: 11956596
    4. Multiple mechanisms for Wnt11-mediated repression of the canonical Wnt signaling pathway.  |  Maye, P., et al. 2004. J Biol Chem. 279: 24659-65. PMID: 15067007
    5. FoxA3 and goosecoid promote anterior neural fate through inhibition of Wnt8a activity before the onset of gastrulation.  |  Seiliez, I., et al. 2006. Dev Biol. 290: 152-63. PMID: 16364286
    6. Wnt signals mediate a fate decision between otic placode and epidermis.  |  Ohyama, T., et al. 2006. Development. 133: 865-75. PMID: 16452098
    7. Gene profiling on mixed embryonic stem cell populations reveals a biphasic role for beta-catenin in osteogenic differentiation.  |  zur Nieden, NI., et al. 2007. Mol Endocrinol. 21: 674-85. PMID: 17170073
    8. Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development.  |  Gavin, BJ., et al. 1990. Genes Dev. 4: 2319-32. PMID: 2279700

    Ordering Information

    Product NameCatalog #UNITPriceQtyFAVORITES

    Wnt-8a Antibody (14-3)

    sc-80459
    100 µg/ml
    $322.00