Wee 1 Activators
Common Wee 1 Activators include, but are not limited to Etoposide (VP-16) CAS 33419-42-0, Doxorubicin CAS 23214-92-8, Hydroxyurea CAS 127-07-1, Cisplatin CAS 15663-27-1 and Fluorouracil CAS 51-21-8.
Wee1 is a tyrosine kinase that plays a pivotal role in cell cycle progression, specifically at the G2/M checkpoint. It functions as a key regulator that ensures cells do not prematurely enter mitosis before completing DNA replication or before DNA damage has been rectified. Wee1 achieves this by phosphorylating and inhibiting the cyclin-dependent kinase 1 (Cdk1), a protein essential for initiating mitosis. By doing so, Wee1 effectively halts the cell cycle, providing the cell ample time to either complete DNA synthesis or repair DNA lesions. This mechanism is crucial for maintaining genomic integrity, as entering mitosis with damaged or incompletely replicated DNA can lead to severe genetic aberrations, which might be detrimental to the cell and the organism.
Activators of Wee1 are molecules or compounds that enhance the expression, stability, or kinase activity of Wee1. These activators can function by augmenting the transcription or translation of the Wee1 gene, by stabilizing the Wee1 protein, or by potentiating its kinase activity against its substrate, Cdk1. The presence and function of Wee1 activators can profoundly influence the dynamics of cell cycle progression, especially in the context of the G2/M checkpoint. Exploring the world of Wee1 activators offers a deep dive into the nuanced regulation of the cell cycle and the intricate mechanisms that cells deploy to safeguard their genomic content. As our grasp of cell cycle regulation continues to deepen, the role of Wee1 and its activators emerges as a central narrative, underscoring the intricate balance cells strike between growth and safeguarding genetic fidelity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
DNA topoisomerase II inhibitor that causes DNA damage, which activates the ATR-Chk1 pathway potentially promoting Wee1 expression to delay entry into mitosis. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Intercalates into DNA and inhibits topoisomerase II, leading to activation of DNA damage response that can upregulate Wee1 as a protective mechanism. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Inhibits ribonucleotide reductase causing decreased dNTPs and stalled DNA replication, which activates the ATR-Chk1 pathway potentially leading to Wee1 upregulation. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Forms DNA adducts leading to DNA damage and activation of DNA repair mechanisms, which might stimulate Wee1 expression as part of the cellular response to damage. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
Pyrimidine analog that inhibits thymidylate synthase causing DNA replication stress, which might upregulate Wee1 to pause cell cycle progression. | ||||||
2′-Deoxy-2′,2′-difluorocytidine | 95058-81-4 | sc-275523 sc-275523A | 1 g 5 g | $56.00 $128.00 | ||
Nucleoside analog that causes DNA replication stress, which can elevate Wee1 expression to delay mitotic entry. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Inhibits DNA topoisomerase I causing DNA breaks, leading to the activation of pathways that might enhance Wee1 expression. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $206.00 $299.00 $485.00 | 10 | |
PARP inhibitor that inhibits DNA repair, leading to accumulation of DNA damage which might stimulate increased Wee1 expression. | ||||||
L-Mimosine | 500-44-7 | sc-201536A sc-201536B sc-201536 sc-201536C | 25 mg 100 mg 500 mg 1 g | $35.00 $86.00 $216.00 $427.00 | 8 | |
L-DOPA analog that inhibits DNA replication inducing cell cycle arrest, potentially elevating Wee1 levels as a response. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $82.00 $300.00 $1082.00 | 30 | |
Inhibits DNA polymerase causing DNA replication stress, which might lead to increased Wee1 to regulate cell cycle progression. | ||||||