WBP5 Activators
WBP5 activators encompass a diverse array of chemical compounds that target different aspects of cellular signaling and chromatin dynamics to enhance the protein's functional activity in transcription elongation. A subset of these activators works by modulating intracellular second messenger levels, such as cAMP, which in turn activates protein kinases like PKA. These kinases have the potential to phosphorylate transcription factors and coactivators, thereby influencing the machinery involved in transcription elongation where WBP5 operates. Other activators function through modulation of the chromatin landscape; for instance, certain compounds inhibit enzymes like DNA methyltransferases and histone deacetylases, leading to an open chromatin conformation that could facilitate the access and movement of the transcriptional machinery. Moreover, such chromatin remodeling may enhance the transcriptional elongation capacity of WBP5 by allowing a more conducive environment for its activity.
Further mechanisms by which WBP5 activity may be augmented include alterations in protein interactions and post-translational modifications. Some activators specifically target kinases, such as AMPK or PKC, that can modify the phosphorylation state of proteins involved in transcription, including factors that may interact with WBP5. Additionally, the activation of protein deacetylases like SIRT1 and the modulation of transcription factor dynamics by ligand-activated nuclear receptors, such as PPARγ, exemplify indirect strategies to potentiate WBP5's role in transcription elongation. By impacting the myriad of proteins that collaborate with WBP5, these activators can facilitate the assembly and function of the transcriptional complex.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Elevates intracellular cAMP levels, leading to activation of PKA. PKA can phosphorylate transcription factors and coactivators involved in transcription elongation, potentially enhancing the function of WBP5 in this process. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C (PKC), which can phosphorylate serine and threonine residues on transcription factors, potentially increasing the transcriptional activity where WBP5 is involved. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Increases intracellular calcium levels, which can activate calmodulin-dependent kinases, potentially impacting the phosphorylation state of proteins involved in transcription elongation and thereby affecting WBP5 activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Inhibits DNA methyltransferases, potentially leading to changes in chromatin structure and improved access for transcriptional machinery, including WBP5-related processes. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Inhibits histone deacetylases, leading to an open chromatin state and potentially facilitating transcription elongation processes where WBP5 is involved. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA demethylating agent that can lead to an open chromatin conformation, potentially enhancing the transcriptional elongation activity of WBP5. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
Donates methyl groups in biological methylation reactions, potentially influencing chromatin states and transcription factor activity, thereby affecting WBP5 function. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Inhibits histone deacetylase, promoting a relaxed chromatin state which may facilitate the transcription elongation role of WBP5. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
Activates AMP-activated protein kinase (AMPK), which can modify transcription factor activity and coactivator interactions, potentially impacting WBP5 function. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Activates sirtuin 1 (SIRT1), a protein deacetylase, which may influence transcription factor activity and chromatin state, potentially impacting WBP5 function in transcription elongation. | ||||||