VZV gE Activators
VZV gE, or Varicella-Zoster Virus glycoprotein E, is a pivotal component of the viral envelope responsible for various essential functions throughout the viral lifecycle. One of its primary functions is to facilitate viral entry into host cells by mediating the fusion of the viral envelope with the host cell membrane. This process involves the interaction of gE with specific cellular receptors or co-receptors, which triggers conformational changes in gE and enables the fusion of the viral envelope with the host cell membrane, thereby allowing the viral genome to enter the host cell cytoplasm and initiate viral replication. Additionally, VZV gE is involved in the assembly and maturation of viral particles within infected cells, contributing to the production and release of infectious virions.
The activation of VZV gE involves a series of intricate molecular mechanisms that regulate its function during viral infection. Upon binding to cellular receptors or co-receptors, gE undergoes structural rearrangements that expose critical domains involved in membrane fusion. These conformational changes trigger the activation of downstream signaling pathways, leading to the recruitment of other viral and cellular factors necessary for efficient viral entry and replication. Moreover, post-translational modifications of gE, such as glycosylation or phosphorylation, may also modulate its activity and interaction with host cell components. Overall, the activation of VZV gE is a tightly regulated process essential for viral infectivity and propagation within the host organism.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a diterpene compound that directly activates adenylyl cyclase, leading to increased levels of intracellular cyclic AMP (cAMP). Elevated cAMP levels can modulate various cellular processes, including protein phosphorylation and ion channel regulation. In the context of VZV gE activation, | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, acts as a ligand for nuclear retinoic acid receptors (RARs) and retinoid X receptors (RXRs). Upon binding to these receptors, retinoic acid modulates gene transcription, impacting cellular differentiation and immune responses. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine, also known as adrenaline, is a neurotransmitter and hormone that activates adrenergic receptors, particularly the β-adrenergic receptors. Activation of these receptors leads to increased intracellular cAMP levels and protein kinase A (PKA) activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), a key enzyme involved in signal transduction. Activation of PKC influences various cellular processes, including gene expression, cell proliferation, and immune responses. In the context of VZV gE activation, PMA's activation of PKC may lead to the modulation of downstream signaling pathways, potentially influencing the activity of VZV gE and enhancing viral replication within host cells. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a synthetic catecholamine that acts as a non-selective β-adrenergic receptor agonist. Stimulation of β-adrenergic receptors increases intracellular cAMP levels and activates protein kinase A (PKA). | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride is a compound that indirectly influences various signaling pathways, including the glycogen synthase kinase-3 (GSK-3) pathway. Inhibition of GSK-3 by lithium chloride can lead to the stabilization of β-catenin and activation of the Wnt signaling pathway. In the context of VZV gE activation, lithium chloride may impact the Wnt signaling pathway, indirectly modulating the activity of VZV gE and potentially promoting viral replication within host cells. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is a synthetic analog of cyclic AMP (cAMP). It directly elevates intracellular cAMP levels, mimicking the effects of endogenous cAMP. Increased cAMP levels can modulate various cellular processes, including protein phosphorylation and gene expression. | ||||||
Dibutyryl-cGMP | 51116-00-8 | sc-200321 sc-200321A | 10 mg 50 mg | $153.00 $398.00 | 11 | |
Dibutyryl-cGMP is a cell-permeable analog of cyclic GMP (cGMP). It directly elevates intracellular cGMP levels, mimicking the effects of endogenous cGMP. Increased cGMP levels can influence various cellular processes, including ion channel regulation and protein phosphorylation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that facilitates the influx of calcium ions into cells. Increased intracellular calcium levels can activate various signaling pathways, including those involving protein kinases and transcription factors. In the context of VZV gE activation, ionomycin's facilitation of calcium influx may lead to the modulation of downstream signaling pathways, potentially influencing the activity of VZV gE and promoting viral replication within host cells. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that, similar to ionomycin, facilitates the influx of calcium ions into cells. Increased intracellular calcium levels can activate various signaling pathways, influencing cellular processes. In the context of VZV gE activation, A23187's facilitation of calcium influx may lead to the modulation of downstream signaling pathways, potentially affecting the activity of VZV gE and promoting viral replication within host cells. | ||||||