VZV gE Inhibitors
VZV gE, also known as glycoprotein E of Varicella-Zoster Virus, is a crucial component of the viral envelope and plays a significant role in viral entry, replication, and pathogenesis. As a viral glycoprotein, gE is involved in multiple stages of the viral lifecycle, including viral attachment to host cells, fusion with cellular membranes, and evasion of host immune responses. Specifically, gE forms a complex with another viral glycoprotein, gI, to facilitate viral entry into host cells by binding to cellular receptors and promoting fusion between the viral envelope and host cell membrane. Additionally, VZV gE is implicated in viral egress from infected cells and spread to neighboring cells, contributing to viral dissemination within the host organism. Moreover, gE has been shown to modulate host immune responses by interfering with the presentation of viral antigens to immune cells and suppressing the activation of immune signaling pathways, thereby aiding viral immune evasion strategies.
Inhibition of VZV gE represents a promising antiviral strategy to prevent viral infection and dissemination. Several mechanisms of inhibition have been proposed, primarily focusing on disrupting the function of gE in viral entry and replication. One approach involves blocking the interaction between gE and its cellular receptors or co-receptors, preventing viral attachment and fusion with host cells. Another strategy targets the fusion activity of gE by interfering with its conformational changes or blocking essential regions involved in membrane fusion. Additionally, inhibition of gE-mediated immune evasion mechanisms, such as interference with antigen presentation or immune signaling pathways, could enhance host immune responses against VZV infection. Overall, targeting VZV gE for inhibition holds promise as an approach to combat Varicella-Zoster Virus infection and associated diseases.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Acyclovir | 59277-89-3 | sc-202906 sc-202906A | 50 mg 500 mg | $150.00 $940.00 | 2 | |
Acyclovir is a nucleoside analog and a viral DNA polymerase inhibitor. It interferes with viral DNA synthesis by acting as a chain terminator during replication. By inhibiting viral DNA synthesis, acyclovir directly targets the replication process of VZV, including the gE protein, resulting in the suppression of viral activity. | ||||||
Foscarnet sodium | 63585-09-1 | sc-205330 sc-205330A | 1 g 5 g | $190.00 $676.00 | ||
Foscarnet is a pyrophosphate analog and a non-competitive inhibitor of viral DNA polymerase. It disrupts the enzymatic activity of DNA polymerase, inhibiting viral DNA synthesis. Through this mechanism, foscarnet directly interferes with the replication of VZV, including the gE protein, leading to the inhibition of viral replication and spread. | ||||||
Ganciclovir | 82410-32-0 | sc-203963 sc-203963A | 50 mg 250 mg | $233.00 $421.00 | 1 | |
Ganciclovir is another nucleoside analog with antiviral properties. It is phosphorylated by viral and cellular kinases, leading to the inhibition of viral DNA synthesis. By disrupting the synthesis of viral DNA, ganciclovir directly inhibits the replication of VZV, including the gE protein, thereby suppressing the spread of the virus within the host cells. | ||||||
Cidofovir | 113852-37-2 | sc-482141 | 50 mg | $135.00 | ||
Cidofovir is a nucleotide analog that inhibits viral DNA polymerase. It is incorporated into growing viral DNA chains, resulting in premature chain termination. Through this mechanism, cidofovir directly interferes with VZV replication, including the function of the gE protein, leading to the inhibition of viral DNA synthesis and subsequent viral spread within the host cells. | ||||||
Brivudine | 69304-47-8 | sc-205607 sc-205607A sc-205607B sc-205607C | 10 mg 25 mg 100 mg 1 g | $224.00 $469.00 $1020.00 $2142.00 | 4 | |
Brivudine is a thymidine analog that inhibits viral DNA synthesis. It is phosphorylated in the host cells and competes with thymidine for incorporation into viral DNA. By disrupting the normal process of DNA synthesis, brivudine directly targets the replication of VZV, including the gE protein, leading to the inhibition of viral replication and the reduction of viral load within the infected host cells. | ||||||
Famciclovir | 104227-87-4 | sc-211498 | 100 mg | $123.00 | ||
Famciclovir is a prodrug that is converted to penciclovir in vivo. Penciclovir, in turn, is a nucleoside analog that inhibits viral DNA polymerase. By interfering with the synthesis of viral DNA, famciclovir and its active metabolite, penciclovir, directly target the replication of VZV, including the gE protein, leading to the inhibition of viral replication and the control of viral spread within the host cells. | ||||||
Vidarabine | 5536-17-4 | sc-205881 sc-205881A | 100 mg 500 mg | $53.00 $140.00 | 1 | |
Vidarabine is an adenine nucleoside analog that inhibits viral DNA synthesis. It is phosphorylated within the host cells and interferes with the normal process of DNA chain elongation. By disrupting viral DNA synthesis, vidarabine directly targets the replication of VZV, including the gE protein, leading to the inhibition of viral replication and the control of viral spread within the host cells. | ||||||
Valacyclovir Hydrochloride | 124832-27-5 | sc-204937 sc-204937A | 50 mg 100 mg | $119.00 $153.00 | ||
Valacyclovir is a prodrug that is converted to acyclovir in vivo. Acyclovir, as mentioned earlier, is a nucleoside analog that inhibits viral DNA polymerase. By interfering with the synthesis of viral DNA, valacyclovir and its active metabolite, acyclovir, directly target the replication of VZV, including the gE protein, leading to the inhibition of viral replication and the control of viral spread within the host cells. | ||||||
Ribavirin | 36791-04-5 | sc-203238 sc-203238A sc-203238B | 10 mg 100 mg 5 g | $63.00 $110.00 $214.00 | 1 | |
Ribavirin is a guanosine nucleoside analog with broad antiviral activity. It interferes with viral RNA and DNA synthesis by multiple mechanisms, including inhibition of inosine monophosphate dehydrogenase. Through these mechanisms, ribavirin directly targets the replication of VZV, including the gE protein, leading to the inhibition of viral replication and the control of viral spread within the host cells. | ||||||
Nitazoxanide | 55981-09-4 | sc-212397 | 10 mg | $124.00 | 1 | |
Nitazoxanide is an antiparasitic and antiviral agent that has been shown to inhibit the replication of various viruses. Its exact mechanism of action is not fully understood, but it is thought to modulate cellular pathways involved in viral replication. Through these mechanisms, nitazoxanide directly targets the replication of VZV, including the gE protein, leading to the inhibition of viral replication and the control of viral spread within the host cells. | ||||||